7PWY

Structure of human dimeric ACMSD in complex with the inhibitor TES-1025

Summary for 7PWY

Entry DOI	10.2210/pdb7pwy/pdb
Descriptor	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, ZINC ION, 2-[3-[(5-cyano-6-oxidanylidene-4-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]ethanoic acid, ... (5 entities in total)
Functional Keywords	acmsd, de-novo nad+ synthesis, tes-1025, decarboxylase, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	153600.00
Authors	Cianci, M.,Giacche, N.,Carotti, A.,Liscio, P.,Amici, A.,Cialabrini, L.,De Franco, F.,Pellicciari, R.,Raffaelli, N. (deposition date: 2021-10-07, release date: 2022-04-20, Last modification date: 2024-01-31)
Primary citation	Cianci, M.,Giacche, N.,Cialabrini, L.,Carotti, A.,Liscio, P.,Rosatelli, E.,De Franco, F.,Gasparrini, M.,Robertson, J.,Amici, A.,Raffaelli, N.,Pellicciari, R. Structural Basis of Human Dimeric alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase Inhibition With TES-1025. Front Mol Biosci, 9:834700-834700, 2022 Cited by PubMed: 35463964 DOI: 10.3389/fmolb.2022.834700 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation