7PWY

Structure of human dimeric ACMSD in complex with the inhibitor TES-1025

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001760	molecular_function	aminocarboxymuconate-semialdehyde decarboxylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006569	biological_process	L-tryptophan catabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019748	biological_process	secondary metabolic process
A	0046872	molecular_function	metal ion binding
A	1904985	biological_process	negative regulation of quinolinate biosynthetic process
A	1905004	biological_process	picolinic acid biosynthetic process
A	1905012	biological_process	regulation of 'de novo' NAD biosynthetic process from L-tryptophan
B	0001760	molecular_function	aminocarboxymuconate-semialdehyde decarboxylase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006569	biological_process	L-tryptophan catabolic process
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019748	biological_process	secondary metabolic process
B	0046872	molecular_function	metal ion binding
B	1904985	biological_process	negative regulation of quinolinate biosynthetic process
B	1905004	biological_process	picolinic acid biosynthetic process
B	1905012	biological_process	regulation of 'de novo' NAD biosynthetic process from L-tryptophan
C	0001760	molecular_function	aminocarboxymuconate-semialdehyde decarboxylase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006569	biological_process	L-tryptophan catabolic process
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0019748	biological_process	secondary metabolic process
C	0046872	molecular_function	metal ion binding
C	1904985	biological_process	negative regulation of quinolinate biosynthetic process
C	1905004	biological_process	picolinic acid biosynthetic process
C	1905012	biological_process	regulation of 'de novo' NAD biosynthetic process from L-tryptophan
D	0001760	molecular_function	aminocarboxymuconate-semialdehyde decarboxylase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006569	biological_process	L-tryptophan catabolic process
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0019748	biological_process	secondary metabolic process
D	0046872	molecular_function	metal ion binding
D	1904985	biological_process	negative regulation of quinolinate biosynthetic process
D	1905004	biological_process	picolinic acid biosynthetic process
D	1905012	biological_process	regulation of 'de novo' NAD biosynthetic process from L-tryptophan

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19843166","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19843166","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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