7PKK

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

Summary for 7PKK

• Entry DOI: 10.2210/pdb7pkk/pdb
• Descriptor: UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, (2R,4R)-1-cyclopropylcarbonyl-4-[[(2S,4S)-4-fluoranylpyrrolidin-2-yl]carbonylamino]-N-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]methyl]pyrrolidine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: elastase, inhibitor, fluoroproline, zinc-binding group, antibiotic, multidrug-resistant gram-negative bacteria, hydrolase
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 1
• Total formula weight: 35524.53

Authors

Ryan, M.D.,Pallin, T.D.,Lamers, M.B.A.C.,Leonard, P.M. (deposition date: 2021-08-25, release date: 2022-09-07, Last modification date: 2024-01-31)

• Primary citation: Ryan, M.D.,Pallin, T.D.,Mullins, T.,Blench, T.,Fraser, I.,Dallow, J.,Ahmed, N.,Ellwood, C.,Gaines, S.,Flores, J.,Blackwell, Y.,Garcia, C.T.,Spence, G.,Reeve, A.,Panchal, T.,Dominguez-Fernandez, B.,Leonard, P.M.,Lamers, M.B.A.C.,Arduin, A.,Fotinou, C.,Gancia, E.,Clark, D.E.,Bush, E.,Betts, J.,Richards, C.,Rea-Davies, T.,Keefe, A.D.,Zhang, Y.,Soutter, H.T.,Centrella, P.A.,Clark, M.A.,Cuozzo, J.W.,Dumelin, C.E.,Habeshian, S.,Hunt, A.,Sigel, E.A.,Troast, D.M.,DeJonge, B.L.M.; LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.55 Å)