7ZZV
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5TB6
| Structure of bromodomain of CREBBP with a pyrazolo[4,3-c]pyridin fragment | 分子名称: | 1,2-ETHANEDIOL, 1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)propan-1-one, CREB-binding protein | 著者 | Filippakopoulos, P, Picaud, S, Knapp, S, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-11 | 公開日 | 2016-10-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett, 7, 2016
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6H3F
| Staphylopine dehydrogenase in complex with staphylopine and NADP+ | 分子名称: | (2~{S})-4-[[(2~{R})-3-(1~{H}-imidazol-4-yl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]butanoic acid, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Hajjar, C, Arnoux, P. | 登録日 | 2018-07-18 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Control by Metals of Staphylopine Dehydrogenase Activity during Metallophore Biosynthesis. J.Am.Chem.Soc., 141, 2019
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1JAN
| COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (PHE79 FORM) | 分子名称: | CALCIUM ION, MATRIX METALLO PROTEINASE-8 (PHE79 FORM), PRO-LEU-GLY-HYDROXYLAMINE INHIBITOR, ... | 著者 | Reinemer, P, Grams, F, Huber, R, Kleine, T, Schnierer, S, Pieper, M, Tschesche, H, Bode, W. | 登録日 | 1996-03-11 | 公開日 | 1996-07-11 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study. FEBS Lett., 338, 1994
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5WJ9
| Human TRPML1 channel structure in agonist-bound open conformation | 分子名称: | 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1 | 著者 | Schmiege, P, Li, X. | 登録日 | 2017-07-21 | 公開日 | 2017-10-18 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Human TRPML1 channel structures in open and closed conformations. Nature, 550, 2017
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6ETB
| Aerobic S262Y mutation of E. coli FLRD core | 分子名称: | Anaerobic nitric oxide reductase flavorubredoxin, FE (III) ION, FLAVIN MONONUCLEOTIDE, ... | 著者 | Borges, P.T, Romao, C.V, Carrondo, M.A, Teixeira, M, Frazao, C. | 登録日 | 2017-10-26 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | 主引用文献 | A tyrosine mutation in E. coli flavodiiron protein increases radiation sensitivity in the crystal structure To Be Published
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1JAP
| COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | 分子名称: | CALCIUM ION, MATRIX METALLO PROTEINASE-8 (MET80 FORM), PRO-LEU-GLY-HYDROXYLAMINE, ... | 著者 | Bode, W, Reinemer, P, Huber, R, Kleine, T, Schnierer, S, Tschesche, H. | 登録日 | 1996-03-11 | 公開日 | 1996-07-11 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J., 13, 1994
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6GZJ
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5WBL
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3FAA
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5EW0
| Crystal structure of the metallo-beta-lactamase Sfh-I in complex with the bisthiazolidine inhibitor L-CS319 | 分子名称: | (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase, ZINC ION | 著者 | Hinchliffe, P, Tooke, C.L, Spencer, J. | 登録日 | 2015-11-20 | 公開日 | 2016-06-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proc.Natl.Acad.Sci.USA, 113, 2016
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5WL8
| Crystal structure of chalcone isomerase engineered from ancestral inference (epR4) | 分子名称: | Engineered Chalcone Isomerase epR4, FORMIC ACID | 著者 | Burke, J.R, Kaltenbach, M, Tawfik, D.S, Noel, J.P. | 登録日 | 2017-07-25 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Evolution of chalcone isomerase from a noncatalytic ancestor. Nat. Chem. Biol., 14, 2018
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5EXI
| Crystal structure of M. tuberculosis lipoyl synthase at 2.28 A resolution | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, IRON/SULFUR CLUSTER, Lipoyl synthase | 著者 | McLaughlin, M.I, Lanz, N.D, Goldman, P.J, Lee, K.-H, Booker, S.J, Drennan, C.L. | 登録日 | 2015-11-23 | 公開日 | 2016-08-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Crystallographic snapshots of sulfur insertion by lipoyl synthase. Proc.Natl.Acad.Sci.USA, 113, 2016
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5EWN
| Crystal structure of the human astrovirus 1 capsid protein core domain at 2.6 A resolution | 分子名称: | CHLORIDE ION, Structural protein | 著者 | York, R.L, Yousefi, P.A, Bogdanoff, W, Haile, S, Tripathi, S, DuBois, R.M. | 登録日 | 2015-11-20 | 公開日 | 2015-12-23 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid. J.Virol., 90, 2015
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5WBH
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6H11
| Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA028 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | 登録日 | 2018-07-10 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.516 Å) | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA028 To be published
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5EXU
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6ATS
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2UUI
| Crystal structure of Human Leukotriene C4 Synthase | 分子名称: | DODECYL-BETA-D-MALTOSIDE, LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, ... | 著者 | Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. | 登録日 | 2007-03-02 | 公開日 | 2007-07-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448, 2007
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5TH2
| Cetuximab Fab in complex with L5Q meditope variant | 分子名称: | L5Q meditope, PHOSPHATE ION, cetuximab Fab, ... | 著者 | Bzymek, K.P, Williams, J.C. | 登録日 | 2016-09-28 | 公開日 | 2016-10-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5F48
| Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with coenzyme A | 分子名称: | CHLORIDE ION, COENZYME A, MAGNESIUM ION, ... | 著者 | Xu, Z, Skarina, T, Stogios, P.J, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2015-12-03 | 公開日 | 2015-12-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes. ACS Infect Dis, 3, 2017
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6AWE
| Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2-fluoro-6-(2-pyridin-2-ylethylamino)benzonitrile | 分子名称: | 2-fluoro-6-{[2-(pyridin-2-yl)ethyl]amino}benzonitrile, DIMETHYL SULFOXIDE, Purine nucleoside phosphorylase | 著者 | Faheem, M, Neto, J.B, Collins, P, Pearce, N.M, Valadares, N.F, Bird, L, Pereira, H.M, Delft, F.V, Barbosa, J.A.R.G. | 登録日 | 2017-09-05 | 公開日 | 2018-09-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2-fluoro-6-(2-pyridin-2-ylethylamino)benzonitrile To Be Published
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5F7A
| Nitrite complex structure of copper nitrite reductase from Alcaligenes faecalis determined at 293 K | 分子名称: | COPPER (II) ION, Copper-containing nitrite reductase, NITRITE ION | 著者 | Fukuda, Y, Tse, K.M, Nakane, T, Nakatsu, T, Suzuki, M, Sugahara, M, Inoue, S, Masuda, T, Yumoto, F, Matsugaki, N, Nango, E, Tono, K, Joti, Y, Kameshima, T, Song, C, Hatsui, T, Yabashi, M, Nureki, O, Murphy, M.E.P, Inoue, T, Iwata, S, Mizohata, E. | 登録日 | 2015-12-07 | 公開日 | 2016-03-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography Proc.Natl.Acad.Sci.USA, 113, 2016
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5EVB
| Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-CS319 | 分子名称: | (3S,5S,7aR)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2015-11-19 | 公開日 | 2016-06-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.841 Å) | 主引用文献 | Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proc.Natl.Acad.Sci.USA, 113, 2016
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6F2D
| A FliPQR complex forms the core of the Salmonella type III secretion system export apparatus. | 分子名称: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | 著者 | Johnson, S, Kuhlen, L, Abrusci, P, Lea, S.M. | 登録日 | 2017-11-24 | 公開日 | 2018-07-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of the core of the type III secretion system export apparatus. Nat. Struct. Mol. Biol., 25, 2018
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