5EVB
Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-CS319
Summary for 5EVB
Entry DOI | 10.2210/pdb5evb/pdb |
Descriptor | Metallo-beta-lactamase L1, ZINC ION, (3S,5S,7aR)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, ... (5 entities in total) |
Functional Keywords | inhibitor, carbapenemase, antibiotic resistance, hydrolase |
Biological source | Stenotrophomonas maltophilia (Pseudomonas maltophilia) |
Cellular location | Periplasm : P52700 |
Total number of polymer chains | 1 |
Total formula weight | 29454.93 |
Authors | Hinchliffe, P.,Spencer, J. (deposition date: 2015-11-19, release date: 2016-06-01, Last modification date: 2024-01-10) |
Primary citation | Hinchliffe, P.,Gonzalez, M.M.,Mojica, M.F.,Gonzalez, J.M.,Castillo, V.,Saiz, C.,Kosmopoulou, M.,Tooke, C.L.,Llarrull, L.I.,Mahler, G.,Bonomo, R.A.,Vila, A.J.,Spencer, J. Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proc.Natl.Acad.Sci.USA, 113:E3745-E3754, 2016 Cited by PubMed: 27303030DOI: 10.1073/pnas.1601368113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.841 Å) |
Structure validation
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