1URF
 
 | | HR1b domain from PRK1 | | 分子名称: | PROTEIN KINASE C-LIKE 1 | | 著者 | Owen, D, Lowe, P.N, Nietlispach, D, Brosnan, C.E, Chirgadze, D.Y, Parker, P.J, Blundell, T.L, Mott, H.R. | | 登録日 | 2003-10-29 | | 公開日 | 2003-11-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular Dissection of the Interaction between the Small G Proteins Rac1 and Rhoa and Protein Kinase C-Related Kinase 1 (Prk1)
J.Biol.Chem., 278, 2003
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8V1P
 | | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH UBF9092 | | 分子名称: | Glucose-induced degradation protein 4 homolog, N,N~2~-bis[(4-methoxyphenyl)methyl]glycinamide | | 著者 | Dong, C, Dong, A, Calabrese, M, Wang, F, Owen, D, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2023-11-21 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH UBF9092
To be published
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1UQV
 | | SAM domain from Ste50p | | 分子名称: | STE50 PROTEIN | | 著者 | Grimshaw, S.J, Mott, H.R, Stott, K.M, Nielsen, P.R, Evetts, K.A, Hopkins, L.J, Nietlispach, D, Owen, D. | | 登録日 | 2003-10-20 | | 公開日 | 2003-10-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the Sterile {Alpha} Motif (Sam) Domain of the Saccharomyces Cerevisiae Mitogen-Activated Protein Kinase Pathway-Modulating Protein Ste50 and Analysis of its Interaction with the Ste11 Sam
J.Biol.Chem., 279, 2004
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4JLG
 | | SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine | | 分子名称: | 8-fluoro-N-{(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl}-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, ... | | 著者 | Dong, A, Wu, H, Zeng, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-03-12 | | 公開日 | 2013-04-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.896 Å) | | 主引用文献 | (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
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1ZSG
 | | beta PIX-SH3 complexed with an atypical peptide from alpha-PAK | | 分子名称: | Rho guanine nucleotide exchange factor 7, Serine/threonine-protein kinase PAK 1 | | 著者 | Mott, H.R, Nietlispach, D, Evetts, K.A, Owen, D. | | 登録日 | 2005-05-24 | | 公開日 | 2005-08-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Analysis of the SH3 Domain of beta-PIX and Its Interaction with alpha-p21 Activated Kinase (PAK)
Biochemistry, 44, 2005
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7NQC
 | | Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane targeting motifs | | 分子名称: | CALCIUM ION, Calmodulin-1, PRO-ASN-GLY-LYS-LYS-LYS-ARG-LYS-SER-LEU-ALA-LYS-ARG-ILE-ARG-GLU-ARG-CMF, ... | | 著者 | Chamberlain, S.G, Owen, D, Mott, H.R. | | 登録日 | 2021-03-01 | | 公開日 | 2021-09-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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4JDS
 | | SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine | | 分子名称: | Histone-lysine N-methyltransferase SETD7, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, S-ADENOSYLMETHIONINE, ... | | 著者 | Dong, A, Wu, H, Zeng, H, Park, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-02-25 | | 公開日 | 2013-03-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
to be published
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1HK6
 | | Ral binding domain from Sec5 | | 分子名称: | EXOCYST COMPLEX COMPONENT SEC5 | | 著者 | Mott, H.R, Nietlispach, D, Hopkins, L.J, Mirey, G, Camonis, J.H, Owen, D. | | 登録日 | 2003-03-05 | | 公開日 | 2003-03-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.
J. Biol. Chem., 278, 2003
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1CF4
 | | CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN (ACTIVATED P21CDC42HS KINASE), ... | | 著者 | Mott, H.R, Owen, D, Nietlispach, D, Lowe, P.N, Lim, L, Laue, E.D. | | 登録日 | 1999-03-23 | | 公開日 | 1999-06-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Nature, 399, 1999
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1E0A
 | | Cdc42 complexed with the GTPase binding domain of p21 activated kinase | | 分子名称: | Cell division control protein 42 homolog, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Morreale, A, Venkatesan, M, Mott, H.R, Owen, D, Nietlispach, D, Lowe, P.N, Laue, E.D. | | 登録日 | 2000-03-16 | | 公開日 | 2000-04-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak
Nat.Struct.Biol., 7, 2000
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5FRG
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2RMK
 | | Rac1/PRK1 Complex | | 分子名称: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1, ... | | 著者 | Modha, R, Campbell, L.J, Nietlispach, D, Buhecha, H.R, Owen, D, Mott, H.R. | | 登録日 | 2007-10-25 | | 公開日 | 2007-11-13 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Rac1 Polybasic Region Is Required for Interaction with Its Effector PRK1
J.Biol.Chem., 283, 2008
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5E7D
 | | Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand | | 分子名称: | (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one, 1,2-ETHANEDIOL, Protein polybromo-1 | | 著者 | Filippakopoulos, P, Picaud, S, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Owen, D, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2015-10-12 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand
To Be Published
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7SLZ
 | | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH BPF023596 | | 分子名称: | Glucose-induced degradation protein 4 homolog, N-[(1s,4s)-4-(1H-benzimidazol-2-yl)cyclohexyl]-N~2~-[(1H-indol-2-yl)methyl]glycinamide | | 著者 | Song, X, Dong, A, Calabrese, M, Wang, F, Owen, D, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2021-10-25 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH BPF023596
To Be Published
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2MBG
 | | Rlip76 (gap-gbd) | | 分子名称: | RalA-binding protein 1 | | 著者 | Rajasekar, K.V, Campbell, L.J, Nietlispach, D, Owen, D, Mott, H.R. | | 登録日 | 2013-07-30 | | 公開日 | 2013-12-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane.
Structure, 21, 2013
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2K9A
 | | The Solution Structure of the Arl2 Effector, BART | | 分子名称: | ADP-ribosylation factor-like protein 2-binding protein | | 著者 | Bailey, L.K, Campbell, L.J, Evetts, K.A, Littlefield, K, Rajendra, E, Nietlispach, D, Owen, D, Mott, H.R. | | 登録日 | 2008-10-06 | | 公開日 | 2008-11-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Structure of Binder of Arl2 (BART) Reveals a Novel G Protein Binding Domain: IMPLICATIONS FOR FUNCTION.
J.Biol.Chem., 284, 2009
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2KWI
 | | RalB-RLIP76 (RalBP1) complex | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RalA-binding protein 1, ... | | 著者 | Fenwick, R.B, Campbell, L.J, Rajasekar, K, Prasannan, S, Nietlispach, D, Camonis, J, Owen, D, Mott, H.R. | | 登録日 | 2010-04-12 | | 公開日 | 2010-09-01 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction
Structure, 18, 2010
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2KWH
 | | Ral binding domain of RLIP76 (RalBP1) | | 分子名称: | RalA-binding protein 1 | | 著者 | Fenwick, R.B, Campbell, L.J, Rajasekar, K, Prasannan, S, Nietlispach, D, Camonis, J, Owen, D, Mott, H.R. | | 登録日 | 2010-04-12 | | 公開日 | 2010-09-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction
Structure, 18, 2010
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2KE5
 | | Solution structure and dynamics of the small GTPase Ralb in its active conformation: significance for effector protein binding | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Ral-B | | 著者 | Fenwick, R, Prasannan, S, Campbell, L.J, Nietlispach, D, Evetts, K.A, Camonis, J, Mott, H.R, Owen, D. | | 登録日 | 2009-01-23 | | 公開日 | 2009-02-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding
Biochemistry, 48, 2009
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6YAF
 | | AP2 on a membrane containing tyrosine-based cargo peptide | | 分子名称: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | 著者 | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | | 登録日 | 2020-03-12 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (9.1 Å) | | 主引用文献 | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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6YAI
 | | Clathrin with bound beta2 appendage of AP2 | | 分子名称: | AP-2 complex subunit beta, Clathrin heavy chain, Clathrin light chain | | 著者 | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | | 登録日 | 2020-03-12 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (9.2 Å) | | 主引用文献 | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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6R28
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6ZRN
 | | Crystal structure of the RLIP76 Ral binding domain mutant (E427S/L429M/Q433L/K440R) in complex with RalB-GMPPNP | | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Hurd, C, Brear, P, Revell, J, Ross, S, Mott, H, Owen, D. | | 登録日 | 2020-07-13 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.482 Å) | | 主引用文献 | Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
J.Biol.Chem., 296, 2020
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4E47
 | | SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine | | 分子名称: | (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETD7, ... | | 著者 | Walker, J.R, Ouyang, H, Dong, A, Fish, P, Cook, A, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-03-12 | | 公開日 | 2012-03-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Setd7 in Complex with Inhibitor and SAM
To be Published
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6ZQT
 | | Crystal structure of the RLIP76 Ral binding domain mutant (E427H/Q433L/K440R) in complex with RalB-GMPPNP | | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Hurd, C, Brear, P, Revell, J, Ross, S, Mott, H, Owen, D. | | 登録日 | 2020-07-10 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
J.Biol.Chem., 296, 2020
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