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PDB: 20 件
1J3F
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Crystal Structure of an Artificial Metalloprotein:Cr(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin
分子名称: 'N,N'-BIS-(2-HYDROXY-3-METHYL-BENZYLIDENE)-BENZENE-1,2-DIAMINE', CHROMIUM ION, Myoglobin, ...
著者Koshiyama, T, Kono, M, Ohashi, M, Ueno, T, Suzuki, A, Yamane, T, Watanabe, Y.
登録日2003-01-24
公開日2004-05-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Coordinated Design of Cofactor and Active Site Structures in Development of New Protein Catalysts
J.Am.Chem.Soc., 127, 2005
4YT1
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Human PPAR Gamma Ligand Binding Domain in complex with a Gammma Selective Synthetic Partial Agonist MEKT76
分子名称: N-(benzylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Ohashi, M, Miyachi, H, Kusunoki, M.
登録日2015-03-17
公開日2016-03-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Peroxisome proliferator-activated receptor gamma (PPAR gamma ) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPAR gamma partial agonists bind to PPAR gamma LBD in different conformations
Bioorg.Med.Chem.Lett., 25, 2015
1V9Q
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Crystal Structure of an Artificial Metalloprotein:Mn(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin
分子名称: 'N,N'-BIS-(2-HYDROXY-3-METHYL-BENZYLIDENE)-BENZENE-1,2-DIAMINE', MANGANESE (III) ION, Myoglobin, ...
著者Ueno, T, Koshiyama, T, Kono, M, Kondo, K, Ohashi, M, Suzuki, A, Yamane, T, Watanabe, Y.
登録日2004-01-29
公開日2005-05-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Coordinated Design of Cofactor and Active Site Structures in Development of New Protein Catalysts
J.Am.Chem.Soc., 127, 2005
6IX8
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The structure of LepI C52A in complex with SAM and its substrate analogue
分子名称: (1R,2R,4aS,8S,8aR)-2,8-dimethyl-5'-phenyl-4a,5,6,7,8,8a-hexahydro-2H,2'H-spiro[naphthalene-1,3'-pyridine]-2',4'(1'H)-dione, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.659 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX5
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The structure of LepI complex with SAM and its substrate analogue
分子名称: 1,2-ETHANEDIOL, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, CHLORIDE ION, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX3
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The structure of LepI complex with SAM
分子名称: CHLORIDE ION, O-methyltransferase lepI, S-ADENOSYLMETHIONINE
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX9
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The structure of LepI C52A in complex with SAM and leporin C
分子名称: (6R,6aS,10S,10aR)-10-methyl-4-phenyl-6-[(1E)-prop-1-en-1-yl]-2,6,6a,7,8,9,10,10a-octahydro-1H-[2]benzopyrano[4,3-c]pyridin-1-one, CHLORIDE ION, GLYCEROL, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.776 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX7
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The structure of LepI C52A in complex with SAH and substrate analogue
分子名称: 1,2-ETHANEDIOL, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, CHLORIDE ION, ...
著者Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
登録日2018-12-09
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.835 Å)
主引用文献Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
7BQO
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The structure of HpiI in complex with its substrate analogue
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[(E,2S,4S)-2,4-dimethyloct-6-enoyl]-4-oxidanyl-1H-pyridin-2-one, GLYCEROL, ...
著者Cai, Y.J, Ohashi, M, Zhou, J.H, Tang, Y.
登録日2020-03-25
公開日2020-10-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献An enzymatic Alder-ene reaction.
Nature, 586, 2020
7BQP
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The structure of HpiI
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, GLYCEROL, ...
著者Cai, Y.J, Ohashi, M, Zhou, J.H, Tang, Y.
登録日2020-03-25
公開日2020-10-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献An enzymatic Alder-ene reaction.
Nature, 586, 2020
3AN3
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Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO3S
分子名称: (2S)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Ohashi, M, Waku, T, Miyachi, H, Morikawa, K.
登録日2010-08-30
公開日2011-07-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
3AN4
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Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO4R
分子名称: (2R)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Ohashi, M, Waku, T, Miyachi, H, Morikawa, K.
登録日2010-08-30
公開日2011-07-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
7BQK
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The structure of PdxI in complex with its substrate analogue
分子名称: 1,2-ETHANEDIOL, 3-[(E,2S,4S)-2,4-dimethyloct-6-enoyl]-4-oxidanyl-1H-pyridin-2-one, GLYCEROL, ...
著者Cai, Y.J, Ohashi, M, Zhou, J.H, Tang, Y.
登録日2020-03-24
公開日2020-10-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献An enzymatic Alder-ene reaction.
Nature, 586, 2020
7BQL
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The crystal structure of PdxI complex with the Alder-ene adduct
分子名称: 3-[(1R,2S,4R,6S)-2-ethenyl-4,6-dimethyl-cyclohexyl]-4-oxidanyl-1H-pyridin-2-one, DI(HYDROXYETHYL)ETHER, Methyltransf_2 domain-containing protein
著者Cai, Y.J, Ohashi, M, Zhou, J.H, Tang, Y.
登録日2020-03-24
公開日2020-10-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献An enzymatic Alder-ene reaction.
Nature, 586, 2020
7BQJ
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The structure of PdxI
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Methyltransf_2 domain-containing protein, ...
著者Cai, Y.J, Ohashi, M, Zhou, J.H, Tang, Y.
登録日2020-03-24
公開日2020-10-14
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献An enzymatic Alder-ene reaction.
Nature, 586, 2020
1UFP
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Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-wild type Myoglobin
分子名称: Myoglobin, PHOSPHATE ION
著者Ueno, T, Ohashi, M, Kono, M, Kondo, K, Suzuki, A, Yamane, T, Watanabe, Y.
登録日2003-06-04
公開日2004-05-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Artificial Metalloproteins: Tight Binding of Fe(III)(Schiff-Base) by Mutation of Ala71 to Gly in Apo-Myoglobin
Inorg.Chem., 43, 2004
1UFJ
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Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin
分子名称: 'N,N'-BIS-(2-HYDROXY-3-METHYL-BENZYLIDENE)-BENZENE-1,2-DIAMINE', FE (III) ION, MYOGLOBIN, ...
著者Ueno, T, Ohashi, M, Kono, M, Kondo, K, Suzuki, A, Yamane, T, Watanabe, Y.
登録日2003-05-30
公開日2004-05-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structures of Artificial Metalloproteins: Tight Binding of Fe(III)(Schiff-Base) by Mutation of Ala71 to Gly in Apo-Myoglobin
Inorg.Chem., 43, 2004
3WMH
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Human PPAR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75
分子名称: N-(phenylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Ohashi, M, Miyachi, H, Kusunoki, M.
登録日2013-11-19
公開日2014-11-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human PPRR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75
TO BE PUBLISHED
3VSO
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Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt21
分子名称: (2R)-2-benzyl-3-[4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)phenyl]propanoic acid, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Waku, T, Ohashi, M, Morikawa, K, Miyachi, H.
登録日2012-04-30
公開日2013-05-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility
Bioorg.Med.Chem., 21, 2013
3VSP
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Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28
分子名称: (2R)-2-benzyl-3-[3-({[4-(piperidin-1-yl)benzoyl]amino}methyl)-4-propoxyphenyl]propanoic acid, Peroxisome proliferator-activated receptor gamma
著者Oyama, T, Waku, T, Ohashi, M, Morikawa, K, Miyachi, H.
登録日2012-04-30
公開日2013-05-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28
To be Published

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