Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt21

Summary for 3VSO

Related3an3 3VSP
DescriptorPeroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-[4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)phenyl]propanoic acid (3 entities in total)
Functional Keywordsmainly alpha, nuclear receptor, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight65570.9
Oyama, T.,Waku, T.,Ohashi, M.,Morikawa, K.,Miyachi, H. (deposition date: 2012-04-30, release date: 2013-05-01)
Primary citation
Ohashi, M.,Oyama, T.,Putranto, E.W.,Waku, T.,Nobusada, H.,Kataoka, K.,Matsuno, K.,Yashiro, M.,Morikawa, K.,Huh, N.H.,Miyachi, H.
Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility
Bioorg.Med.Chem., 21:2319-2332, 2013
PubMed: 23490155 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmc.2013.02.003
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25610 0.8% 3.8% 4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21