4YT1
Human PPAR Gamma Ligand Binding Domain in complex with a Gammma Selective Synthetic Partial Agonist MEKT76
Summary for 4YT1
Entry DOI | 10.2210/pdb4yt1/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, N-(benzylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide (3 entities in total) |
Functional Keywords | nuclear receptor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65605.93 |
Authors | Oyama, T.,Ohashi, M.,Miyachi, H.,Kusunoki, M. (deposition date: 2015-03-17, release date: 2016-03-02, Last modification date: 2023-11-08) |
Primary citation | Ohashi, M.,Gamo, K.,Oyama, T.,Miyachi, H. Peroxisome proliferator-activated receptor gamma (PPAR gamma ) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPAR gamma partial agonists bind to PPAR gamma LBD in different conformations Bioorg.Med.Chem.Lett., 25:2758-2762, 2015 Cited by PubMed: 26025876DOI: 10.1016/j.bmcl.2015.05.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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