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PDB: 13 results
8S42
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BU of 8s42 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 80 (1124898)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-1-[8-[3-fluoranyl-4-(trifluoromethyl)phenyl]sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]ethanone, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2024-02-21
Release date:2025-03-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QDV
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BU of 8qdv by Molmil
Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide
Descriptor: 14-3-3 protein zeta/delta, Microtubule-associated protein tau
Authors:van den Oetelaar, M.C.M, Brunsveld, L, Ottmann, C.
Deposit date:2023-08-30
Release date:2024-09-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:14-3-3zeta binding increases cytosolic phospho-Tau solubility by decreasing its condensation, aggregation, and microtubule association
To Be Published
8Q5C
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BU of 8q5c by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 12 (1075475)
Descriptor: 14-3-3 protein sigma, C-RAF peptide pS259, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-08-08
Release date:2025-02-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8Q55
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BU of 8q55 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 21 (1075354)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methyl]ethanamide, C-RAF peptide pS259, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-08-08
Release date:2025-02-19
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8C2E
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BU of 8c2e by Molmil
Structure of 14-3-3 sigma delta C with electrophilic peptide 4IEA-5
Descriptor: 14-3-3 protein sigma, ARG-SER-ALA-SEP-CYS-PRO-SER-LEU, CHLORIDE ION, ...
Authors:van den Oetelaar, M.C.M, Ottmann, C.
Deposit date:2022-12-22
Release date:2023-11-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A simple method for developing lysine targeted covalent protein reagents.
Nat Commun, 14, 2023
8C2F
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BU of 8c2f by Molmil
Structure of 14-3-3 sigma delta C with electrophilic peptide 3MHR-5
Descriptor: 14-3-3 protein sigma, ARG-ALA-HIS-SEP-CYS-PRO-ALA-SER-LEU-GLN, CHLORIDE ION, ...
Authors:van den Oetelaar, M.C.M, Ottmann, C.
Deposit date:2022-12-22
Release date:2023-11-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A simple method for developing lysine targeted covalent protein reagents.
Nat Commun, 14, 2023
8C5L
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BU of 8c5l by Molmil
NR2F6 ligand binding domain in complex with NSD1 peptide
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-36 specific, Maltose/maltodextrin-binding periplasmic protein,Nuclear receptor subfamily 2 group F member 6, ...
Authors:Oerlemans, G.J.M, van den Oetelaar, M.C.M, Brunsveld, L.
Deposit date:2023-01-09
Release date:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into coregulator recruitment to the autorepressed NR2F6 nuclear receptor
To Be Published
9EW5
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BU of 9ew5 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) 12mer and compound 23 (1083848)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide, CALCIUM ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2024-04-03
Release date:2025-04-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
9EW4
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BU of 9ew4 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide 12mer (pS259) and compound 86 (1124384)
Descriptor: 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2024-04-03
Release date:2025-04-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
9EW3
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BU of 9ew3 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide 12-mer (pS259) and compound 78 (1084378)
Descriptor: 1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, CALCIUM ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2024-04-03
Release date:2025-04-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
9EW6
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BU of 9ew6 by Molmil
Binary structure of 14-3-3s and BRAF phosphopeptide (pS365)
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2024-04-03
Release date:2025-04-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
9EW1
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BU of 9ew1 by Molmil
Ternary structure of 14-3-3s, CRAF phosphopeptide (pS259) and compound 79 (1124379).
Descriptor: 14-3-3 protein sigma, 2-chloranyl-1-[8-(4-iodophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]ethanone, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2024-04-03
Release date:2025-04-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
9EW7
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BU of 9ew7 by Molmil
Binary structure of 14-3-3s and CRAF phosphopeptide (pS259)
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2024-04-03
Release date:2025-04-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published

234785

PDB entries from 2025-04-16

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