9EW4

Ternary structure of 14-3-3s, C-RAF phosphopeptide 12mer (pS259) and compound 86 (1124384)

Summary for 9EW4

• Entry DOI: 10.2210/pdb9ew4/pdb
• Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: stabilizer, protein-protein interaction, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28185.34

Authors

Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. (deposition date: 2024-04-03, release date: 2025-04-16)

• Primary citation: Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R.; Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)