9EW7

Binary structure of 14-3-3s and CRAF phosphopeptide (pS259)

Summary for 9EW7

Entry DOI	10.2210/pdb9ew7/pdb
Descriptor	14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	14-3-3 protein, protein-protein interactions, peptide binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	27915.31
Authors	Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. (deposition date: 2024-04-03, release date: 2025-04-16)
Primary citation	Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published,
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation