8QSH

Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 23 (1083848).

Summary for 8QSH

Entry DOI	10.2210/pdb8qsh/pdb
Descriptor	14-3-3 protein sigma, ARAF peptide pS214, 2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide, ... (6 entities in total)
Functional Keywords	14-3-3, protein-protein interaction stabilizer, peptide binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	57203.51
Authors	Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. (deposition date: 2023-10-10, release date: 2025-04-23)
Primary citation	Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published,
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation