9EW5

Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) 12mer and compound 23 (1083848)

Summary for 9EW5

• Entry DOI: 10.2210/pdb9ew5/pdb
• Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase, 2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide, ... (6 entities in total)
• Functional Keywords: stabilizer, protein-protein interaction, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 56822.56

Authors

Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. (deposition date: 2024-04-03, release date: 2025-04-16)

• Primary citation: Konstantinidou, M.,Vickery, H.,Pennings, M.A.M.,Virta, J.,Visser, E.J.,Oetelaar, M.C.M.,Overmans, M.,Neitz, J.,Ottmann, C.,Brunsveld, L.,Arkin, M.R.; Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)