9EW5
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) 12mer and compound 23 (1083848)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 2 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B, D (C, F) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 11 | 1339.4 | 2 | UniProt (P04049) | Homo sapiens | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 3 | E, H (A, D) | 2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide | non-polymer | 456.7 | 2 | Chemie (WQI) | |||
| 4 | F, I, J (A, D) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 5 | G (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | K, L, M, N (A, C, D, F) | water | water | 18.0 | 437 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55764.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1058.0 | |
| All* | Total formula weight | 56822.6 |
