6LPB
 
 | | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. | | Deposit date: | 2020-01-09 | | Release date: | 2020-03-11 | | Last modified: | 2020-03-25 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.
Nat.Struct.Mol.Biol., 27, 2020
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6LMX
 | | Cryo-EM structure of the CALHM chimeric construct (9-mer) | | Descriptor: | Calcium homeostasis modulator 1,Calcium homeostasis modulator protein 2 | | Authors: | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-12-26 | | Release date: | 2020-07-29 | | Last modified: | 2020-09-09 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Sci Adv, 6, 2020
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6M04
 | | Structure of the human homo-hexameric LRRC8D channel at 4.36 Angstroms | | Descriptor: | Volume-regulated anion channel subunit LRRC8D | | Authors: | Nakamura, R, Kasuya, G, Yokoyama, T, Shirouzu, M, Ishitani, R, Nureki, O. | | Deposit date: | 2020-02-20 | | Release date: | 2020-06-17 | | Method: | ELECTRON MICROSCOPY (4.36 Å) | | Cite: | Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Commun Biol, 3, 2020
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6LMV
 | | Cryo-EM structure of the C. elegans CLHM-1 | | Descriptor: | Calcium homeostasis modulator protein | | Authors: | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-12-26 | | Release date: | 2020-07-29 | | Last modified: | 2020-09-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Sci Adv, 6, 2020
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6LRY
 | | Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b | | Descriptor: | Endothelin receptor type B,Endolysin,Endothelin receptor type B, Sarafotoxin-B | | Authors: | Izume, T, Miyauchi, H, Shihoya, W, Nureki, O. | | Deposit date: | 2020-01-16 | | Release date: | 2020-02-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of human endothelin ETBreceptor in complex with sarafotoxin S6b.
Biochem.Biophys.Res.Commun., 528, 2020
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6LMW
 | | Cryo-EM structure of the CALHM chimeric construct (8-mer) | | Descriptor: | Calcium homeostasis modulator 1,Calcium homeostasis modulator protein 2 | | Authors: | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-12-26 | | Release date: | 2020-07-29 | | Last modified: | 2020-09-09 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Sci Adv, 6, 2020
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6LPJ
 | | A2AR crystallized in EROCOC17+4, LCP-SFX at 277 K | | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | | Authors: | Ihara, K, Hato, M, Nakane, T, Yamashita, K, Kimura-Someya, T, Hosaka, T, Ishizuka-Katsura, Y, Tanaka, R, Tanaka, T, Sugahara, M, Hirata, K, Yamamoto, M, Nureki, O, Tono, K, Nango, E, Iwata, S, Shirouzu, M. | | Deposit date: | 2020-01-10 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography.
Sci Rep, 10, 2020
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6LPL
 | | A2AR crystallized in EROCOC17+4, SS-ROX at 100 K | | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | | Authors: | Ihara, K, Hato, M, Nakane, T, Yamashita, K, Kimura-Someya, T, Hosaka, T, Ishizuka-Katsura, Y, Tanaka, R, Tanaka, T, Sugahara, M, Hirata, K, Yamamoto, M, Nureki, O, Tono, K, Nango, E, Iwata, S, Shirouzu, M. | | Deposit date: | 2020-01-11 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography.
Sci Rep, 10, 2020
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6LMT
 | | Cryo-EM structure of the killifish CALHM1 | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Calcium homeostasis modulator 1 | | Authors: | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-12-26 | | Release date: | 2020-07-29 | | Last modified: | 2020-09-09 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Sci Adv, 6, 2020
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6IS6
 | | Crystal structure of Thermoplasmatales archaeon heliorhodopsin | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, RETINAL, heliorhodopsin | | Authors: | Shihoya, W, Yamashita, K, Nureki, O. | | Deposit date: | 2018-11-15 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of heliorhodopsin.
Nature, 574, 2019
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1UDS
 | | Crystal structure of the tRNA processing enzyme RNase PH R126A mutant from Aquifex aeolicus | | Descriptor: | PHOSPHATE ION, Ribonuclease PH, SULFATE ION | | Authors: | Ishii, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-02 | | Release date: | 2003-09-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the tRNA Processing Enzyme RNase PH from Aquifex aeolicus
J.Biol.Chem., 278, 2003
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1UDN
 | | Crystal structure of the tRNA processing enzyme RNase PH from Aquifex aeolicus | | Descriptor: | PHOSPHATE ION, Ribonuclease PH, SULFATE ION | | Authors: | Ishii, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-02 | | Release date: | 2003-09-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the tRNA Processing Enzyme RNase PH from Aquifex aeolicus
J.Biol.Chem., 278, 2003
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1UDZ
 | | Isoleucyl-tRNA synthetase editing domain | | Descriptor: | Isoleucyl-tRNA synthetase | | Authors: | Fukunaga, R, Fukai, S, Ishitani, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-08 | | Release date: | 2004-03-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine.
J.Biol.Chem., 279, 2004
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1UDO
 | | Crystal structure of the tRNA processing enzyme RNase PH R86A mutant from Aquifex aeolicus | | Descriptor: | PHOSPHATE ION, Ribonuclease PH, SULFATE ION | | Authors: | Ishii, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-02 | | Release date: | 2003-09-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the tRNA Processing Enzyme RNase PH from Aquifex aeolicus
J.Biol.Chem., 278, 2003
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1UDQ
 | | Crystal structure of the tRNA processing enzyme RNase PH T125A mutant from Aquifex aeolicus | | Descriptor: | PHOSPHATE ION, Ribonuclease PH, SULFATE ION | | Authors: | Ishii, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-02 | | Release date: | 2003-09-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the tRNA Processing Enzyme RNase PH from Aquifex aeolicus
J.Biol.Chem., 278, 2003
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1UE0
 | | Isoleucyl-tRNA synthetase editing domain complexed with L-Valine | | Descriptor: | Isoleucyl-tRNA synthetase, VALINE | | Authors: | Fukunaga, R, Fukai, S, Ishitani, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-08 | | Release date: | 2004-03-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine.
J.Biol.Chem., 279, 2004
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1UFA
 | | Crystal structure of TT1467 from Thermus thermophilus HB8 | | Descriptor: | TT1467 protein | | Authors: | Idaka, M, Terada, T, Murayama, K, Yamaguchi, H, Nureki, O, Ishitani, R, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-28 | | Release date: | 2003-11-28 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of TT1467 from Thermus thermophilus HB8
To be published
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1ULH
 | | A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase | | Descriptor: | Tryptophanyl-tRNA synthetase | | Authors: | Kise, Y, Sengoku, T, Ishii, R, Yokoyama, S, Park, S.G, Lee, S.W, Kim, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-09-12 | | Release date: | 2004-02-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Nat.Struct.Mol.Biol., 11, 2004
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1V33
 | | Crystal structure of DNA primase from Pyrococcus horikoshii | | Descriptor: | DNA primase small subunit, PHOSPHATE ION, ZINC ION | | Authors: | Ito, N, Nureki, O, Shirouzu, M, Yokoyama, S, Hanaoka, F, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-10-25 | | Release date: | 2004-03-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.
Genes Cells, 8, 2003
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1V34
 | | Crystal structure of Pyrococcus horikoshii DNA primase-UTP complex | | Descriptor: | DNA primase small subunit, URIDINE 5'-TRIPHOSPHATE, ZINC ION | | Authors: | Ito, N, Nureki, O, Shirouzu, M, Yokoyama, S, Hanaoka, F, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-10-25 | | Release date: | 2004-03-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.
Genes Cells, 8, 2003
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7V94
 | | Cryo-EM structure of the Cas12c2-sgRNA-target DNA ternary complex | | Descriptor: | Cas12c2, sgRNA, target DNA (non target strand), ... | | Authors: | Kurihara, N, Hirano, H, Tomita, A, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | | Deposit date: | 2021-08-24 | | Release date: | 2022-04-13 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structure of the type V-C CRISPR-Cas effector enzyme.
Mol.Cell, 82, 2022
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7V74
 | | Thermostabilized human prestin in complex with sulfate | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, SULFATE ION, ... | | Authors: | Futamata, H, Fukuda, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2021-08-21 | | Release date: | 2022-08-31 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.
Nat Commun, 13, 2022
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7VVJ
 | | PTHrP-bound human PTH1R in complex with Gs | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | | Deposit date: | 2021-11-06 | | Release date: | 2022-08-03 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor.
Mol.Cell, 82, 2022
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7VVL
 | | PTH-bound human PTH1R in complex with Gs (class2) | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | | Deposit date: | 2021-11-06 | | Release date: | 2022-08-03 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor.
Mol.Cell, 82, 2022
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7VVN
 | | PTH-bound human PTH1R in complex with Gs (class4) | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | | Deposit date: | 2021-11-06 | | Release date: | 2022-08-03 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor.
Mol.Cell, 82, 2022
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