4UPA
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4UP8
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4UP9
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3VVP
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![BU of 3vvp by Molmil](/molmil-images/mine/3vvp) | Crystal structure of MATE in complex with Br-NRF | Descriptor: | 6-bromo-1-ethyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, Putative uncharacterized protein | Authors: | Tanaka, Y, Ishitani, R, Nureki, O. | Deposit date: | 2012-07-27 | Release date: | 2013-04-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
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5NDC
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![BU of 5ndc by Molmil](/molmil-images/mine/5ndc) | Structure of ba3-type cytochrome c oxidase from Thermus thermophilus by serial femtosecond crystallography | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide IIA, ... | Authors: | Andersson, R, Safari, C, Dods, R, Nango, E, Tanaka, R, Nakane, T, Tono, K, Joti, Y, Bath, P, Dunevall, E, Bosman, E, Nureki, O, Iwata, S, Neutze, R, Branden, G. | Deposit date: | 2017-03-08 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature. Sci Rep, 7, 2017
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6AI6
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![BU of 6ai6 by Molmil](/molmil-images/mine/6ai6) | Crystal structure of SpCas9-NG | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), ... | Authors: | Nishimasu, H, Hirano, S, Ishitani, R, Nureki, O. | Deposit date: | 2018-08-21 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Engineered CRISPR-Cas9 nuclease with expanded targeting space Science, 361, 2018
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4GEL
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![BU of 4gel by Molmil](/molmil-images/mine/4gel) | Crystal structure of Zucchini | Descriptor: | 1,2-ETHANEDIOL, Mitochondrial cardiolipin hydrolase, PHOSPHATE ION, ... | Authors: | Nishimasu, H, Fukuhara, S, Ishitani, R, Nureki, O. | Deposit date: | 2012-08-02 | Release date: | 2012-10-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.756 Å) | Cite: | Structure and function of Zucchini endoribonuclease in piRNA biogenesis Nature, 491, 2012
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6AEL
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![BU of 6ael by Molmil](/molmil-images/mine/6ael) | Crystal structure of ENPP1 in complex with 3'3'-cGAMP | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, ... | Authors: | Kato, K, Nishimasu, H, Hirano, S, Hirano, H, Ishitani, R, Nureki, O. | Deposit date: | 2018-08-05 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun, 9, 2018
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6LPL
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![BU of 6lpl by Molmil](/molmil-images/mine/6lpl) | A2AR crystallized in EROCOC17+4, SS-ROX at 100 K | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | Authors: | Ihara, K, Hato, M, Nakane, T, Yamashita, K, Kimura-Someya, T, Hosaka, T, Ishizuka-Katsura, Y, Tanaka, R, Tanaka, T, Sugahara, M, Hirata, K, Yamamoto, M, Nureki, O, Tono, K, Nango, E, Iwata, S, Shirouzu, M. | Deposit date: | 2020-01-11 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography. Sci Rep, 10, 2020
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1N77
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![BU of 1n77 by Molmil](/molmil-images/mine/1n77) | Crystal structure of Thermus thermophilus glutamyl-tRNA synthetase complexed with tRNA(Glu) and ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Glutamyl-tRNA synthetase, MAGNESIUM ION, ... | Authors: | Sekine, S, Nureki, O, Dubois, D.Y, Bernier, S, Chenevert, R, Lapointe, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-11-13 | Release date: | 2003-02-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding EMBO J., 22, 2003
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1N75
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![BU of 1n75 by Molmil](/molmil-images/mine/1n75) | Crystal structure of Thermus thermophilus glutamyl-tRNA synthetase complexed with ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Glutamyl-tRNA synthetase, MAGNESIUM ION | Authors: | Sekine, S, Nureki, O, Dubois, D.Y, Bernier, S, Chenevert, R, Lapointe, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-11-12 | Release date: | 2003-02-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding EMBO J., 22, 2003
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1N78
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![BU of 1n78 by Molmil](/molmil-images/mine/1n78) | Crystal structure of Thermus thermophilus glutamyl-tRNA synthetase complexed with tRNA(Glu) and glutamol-AMP. | Descriptor: | GLUTAMOL-AMP, Glutamyl-tRNA synthetase, MAGNESIUM ION, ... | Authors: | Sekine, S, Nureki, O, Dubois, D.Y, Bernier, S, Chenevert, R, Lapointe, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-11-13 | Release date: | 2003-02-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding EMBO J., 22, 2003
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6LMT
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![BU of 6lmt by Molmil](/molmil-images/mine/6lmt) | Cryo-EM structure of the killifish CALHM1 | Descriptor: | CHOLESTEROL HEMISUCCINATE, Calcium homeostasis modulator 1 | Authors: | Demura, K, Kusakizako, T, Shihoya, W, Hiraizumi, M, Shimada, H, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2019-12-26 | Release date: | 2020-07-29 | Last modified: | 2020-09-09 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Sci Adv, 6, 2020
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5JYJ
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![BU of 5jyj by Molmil](/molmil-images/mine/5jyj) | Crystal structure of mouse JUNO | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sperm-egg fusion protein Juno | Authors: | Kato, K, Nishimasu, H, Morita, J, Ishitani, R, Nureki, O. | Deposit date: | 2016-05-14 | Release date: | 2017-05-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the egg IZUMO1 receptor JUNO To Be Published
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6LPK
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![BU of 6lpk by Molmil](/molmil-images/mine/6lpk) | A2AR crystallized in EROCOC17+4, LCP-SFX at 293 K | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | Authors: | Ihara, K, Hato, M, Nakane, T, Yamashita, K, Kimura-Someya, T, Hosaka, T, Ishizuka-Katsura, Y, Tanaka, R, Tanaka, T, Sugahara, M, Hirata, K, Yamamoto, M, Nureki, O, Tono, K, Nango, E, Iwata, S, Shirouzu, M. | Deposit date: | 2020-01-10 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography. Sci Rep, 10, 2020
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6LPJ
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![BU of 6lpj by Molmil](/molmil-images/mine/6lpj) | A2AR crystallized in EROCOC17+4, LCP-SFX at 277 K | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | Authors: | Ihara, K, Hato, M, Nakane, T, Yamashita, K, Kimura-Someya, T, Hosaka, T, Ishizuka-Katsura, Y, Tanaka, R, Tanaka, T, Sugahara, M, Hirata, K, Yamamoto, M, Nureki, O, Tono, K, Nango, E, Iwata, S, Shirouzu, M. | Deposit date: | 2020-01-10 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography. Sci Rep, 10, 2020
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2YVX
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![BU of 2yvx by Molmil](/molmil-images/mine/2yvx) | Crystal structure of magnesium transporter MgtE | Descriptor: | MAGNESIUM ION, Mg2+ transporter MgtE | Authors: | Hattori, M, Tanaka, Y, Fukai, S, Ishitani, R, Nureki, O. | Deposit date: | 2007-04-18 | Release date: | 2007-09-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the MgtE Mg(2+) transporter Nature, 448, 2007
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6LPB
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![BU of 6lpb by Molmil](/molmil-images/mine/6lpb) | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. | Deposit date: | 2020-01-09 | Release date: | 2020-03-11 | Last modified: | 2020-03-25 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nat.Struct.Mol.Biol., 27, 2020
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6LGP
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![BU of 6lgp by Molmil](/molmil-images/mine/6lgp) | cryo-EM structure of TRPV3 in lipid nanodisc | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, DIUNDECYL PHOSPHATIDYL CHOLINE, Transient receptor potential cation channel subfamily V member 3 | Authors: | Shimada, H, Kusakizako, T, Nishizawa, T, Nureki, O. | Deposit date: | 2019-12-05 | Release date: | 2020-06-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism. Nat.Struct.Mol.Biol., 27, 2020
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7YNZ
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7YO0
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![BU of 7yo0 by Molmil](/molmil-images/mine/7yo0) | Cryo-EM structure of human Slo1-LRRC26 complex with Symmetry Expansion | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Calcium-activated potassium channel subunit alpha-1, ... | Authors: | Yamanouchi, D, Nureki, O. | Deposit date: | 2022-08-01 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex To Be Published
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7YO1
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1A8H
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![BU of 1a8h by Molmil](/molmil-images/mine/1a8h) | METHIONYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS | Descriptor: | METHIONYL-TRNA SYNTHETASE, ZINC ION | Authors: | Sugiura, I, Nureki, O, Ugaji, Y, Kuwabara, S, Lober, B, Giege, R, Moras, D, Yokoyama, S, Konno, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 1998-03-26 | Release date: | 1999-05-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The 2.0 A crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules. Structure, 8, 2000
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1B7F
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![BU of 1b7f by Molmil](/molmil-images/mine/1b7f) | SXL-LETHAL PROTEIN/RNA COMPLEX | Descriptor: | PROTEIN (SXL-LETHAL PROTEIN), RNA (5'-R(P*GP*UP*UP*GP*UP*UP*UP*UP*UP*UP*UP*U)-3') | Authors: | Handa, N, Nureki, O, Kurimoto, K, Kim, I, Sakamoto, H, Shimura, Y, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 1999-01-23 | Release date: | 1999-05-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein. Nature, 398, 1999
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2RRN
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![BU of 2rrn by Molmil](/molmil-images/mine/2rrn) | Solution structure of SecDF periplasmic domain P4 | Descriptor: | Probable SecDF protein-export membrane protein | Authors: | Tanaka, T, Tsukazaki, T, Echizen, Y, Nureki, O, Kohno, T. | Deposit date: | 2011-01-30 | Release date: | 2011-05-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure and function of a membrane component SecDF that enhances protein export Nature, 474, 2011
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