7VOE
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![BU of 7voe by Molmil](/molmil-images/mine/7voe) | Crystal structure of 5-HT2AR in complex with aripiprazole | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, ... | 著者 | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | 登録日 | 2021-10-13 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat.Neurosci., 25, 2022
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7VOD
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![BU of 7vod by Molmil](/molmil-images/mine/7vod) | Crystal structure of 5-HT2AR in complex with cariprazine | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | 登録日 | 2021-10-13 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat.Neurosci., 25, 2022
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6LUQ
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![BU of 6luq by Molmil](/molmil-images/mine/6luq) | Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands | 分子名称: | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one, OLEIC ACID, chimera of D(2) dopamine receptor and Endolysin | 著者 | Fan, L, Tan, L, Chen, Z, Qi, J, Nie, F, Luo, Z, Cheng, J, Wang, S. | 登録日 | 2020-01-30 | 公開日 | 2020-03-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Haloperidol bound D2dopamine receptor structure inspired the discovery of subtype selective ligands. Nat Commun, 11, 2020
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1JYQ
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![BU of 1jyq by Molmil](/molmil-images/mine/1jyq) | Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide | 分子名称: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor | 著者 | Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. | 登録日 | 2001-09-13 | 公開日 | 2002-03-13 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
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2ID2
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![BU of 2id2 by Molmil](/molmil-images/mine/2id2) | GAPN T244S mutant X-ray structure at 2.5 A | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, SULFATE ION | 著者 | Pailot, A, D'Ambrosio, K, Corbier, C, Talfournier, F, Branlant, G. | 登録日 | 2006-09-14 | 公開日 | 2007-09-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans. Biochem.J., 400, 2006
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2WEK
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![BU of 2wek by Molmil](/molmil-images/mine/2wek) | Crystal structure of the human MGC45594 gene product in complex with diclofenac | 分子名称: | 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, CHLORIDE ION, GLYCEROL, ... | 著者 | Shafqat, N, Yue, W.W, Ugochukwu, E, Niesen, F, Smee, C, Arrowsmith, C, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U. | 登録日 | 2009-03-31 | 公開日 | 2009-12-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of the Human Mgc45594 Gene Product in Complex with Diclofenac To be Published
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1T90
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![BU of 1t90 by Molmil](/molmil-images/mine/1t90) | Crystal structure of methylmalonate semialdehyde dehydrogenase from Bacillus subtilis | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Probable methylmalonate-semialdehyde dehydrogenase | 著者 | Dubourg, H, Didierjean, C, Stines-Chaumeil, C, Talfournier, F, Branlant, G, Aubry, A, Corbier, C. | 登録日 | 2004-05-14 | 公開日 | 2006-01-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure analysis of Methylmalonate-Semialdehyde Dehydrogenase from Bacillus subtilis. To be published
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1JYU
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![BU of 1jyu by Molmil](/molmil-images/mine/1jyu) | Xray Structure of Grb2 SH2 Domain | 分子名称: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 | 著者 | Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. | 登録日 | 2001-09-13 | 公開日 | 2002-03-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
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1T5P
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![BU of 1t5p by Molmil](/molmil-images/mine/1t5p) | Human Heme Oxygenase Oxidation of alpha- and gamma-meso-phenylhemes | 分子名称: | 12-PHENYLHEME, Heme oxygenase 1 | 著者 | Wang, J, Niemevz, F, Lad, L, Buldain, G, Poulos, T.L, Ortiz de Montellano, P.R. | 登録日 | 2004-05-05 | 公開日 | 2004-08-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Human heme oxygenase oxidation of 5- and 15-phenylhemes. J.Biol.Chem., 279, 2004
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7OU3
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![BU of 7ou3 by Molmil](/molmil-images/mine/7ou3) | Crystal structure of Tga-AGOG, an 8-oxoguanine DNA glycosylase from Thermococcus gammatolerans | 分子名称: | CHLORIDE ION, GLYCEROL, N-glycosylase/DNA lyase | 著者 | Coste, F, Confalonieri, F, Castaing, B. | 登録日 | 2021-06-11 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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2XDV
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![BU of 2xdv by Molmil](/molmil-images/mine/2xdv) | Crystal Structure of the Catalytic Domain of FLJ14393 | 分子名称: | 1,2-ETHANEDIOL, CADMIUM ION, MANGANESE (II) ION, ... | 著者 | Krojer, T, Muniz, J.R.C, Ng, S.S, Pilka, E, Guo, K, Pike, A.C.W, Filippakopoulos, P, Knapp, S, Kavanagh, K.L, Gileadi, O, Bunkoczi, G, Yue, W.W, Niesen, F, Sobott, F, Fedorov, O, Savitsky, P, Kochan, G, Daniel, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Oppermann, U. | 登録日 | 2010-05-07 | 公開日 | 2010-05-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014
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7ZEJ
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![BU of 7zej by Molmil](/molmil-images/mine/7zej) | Crystal structure of the human MGC45594 gene product in complex with celecoxib. | 分子名称: | 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin reductase 3 | 著者 | Shafqat, N, Yue, W.W, Koekemoer, L, Niesen, F, Ugochukwu, E, Vollmar, M, Weigelt, J, Krojer, T, Pike, A, Chaikaud, A, Von Delft, F, Arrowsmith, C, Bountra, C, Edwards, A, Opperman, U, Structural Genomics Consortium (SGC) | 登録日 | 2022-03-31 | 公開日 | 2022-05-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Human prostaglandin/alkenal reductases: substrate specificities, inhibitor profiles, structural insights and subcellular localization suggest protective roles in inflammatory and oxidative stress conditions. To Be Published
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1SZ7
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![BU of 1sz7 by Molmil](/molmil-images/mine/1sz7) | Crystal structure of Human Bet3 | 分子名称: | PALMITIC ACID, Trafficking protein particle complex subunit 3 | 著者 | Turnbull, A.P, Prinz, B, Holz, C, Behlke, J, Schultchen, J, Delbrueck, H, Niesen, F.H, Lang, C, Heinemann, U. | 登録日 | 2004-04-05 | 公開日 | 2005-01-18 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization Embo J., 24, 2005
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2J1L
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![BU of 2j1l by Molmil](/molmil-images/mine/2j1l) | Crystal Structure of Human Rho-related GTP-binding protein RhoD | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RHO-RELATED GTP-BINDING PROTEIN RHOD | 著者 | Pike, A.C.W, Johansson, C, Gileadi, C, Niesen, F.H, Sobott, F, Schoch, G, Elkins, J, Smee, C, Gorrec, F, Watt, S, Bray, J, Turnbull, A.P, von Delft, F, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Doyle, D. | 登録日 | 2006-08-14 | 公開日 | 2006-09-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of Human Rho-Related GTP-Binding Protein Rhod To be Published
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8B45
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![BU of 8b45 by Molmil](/molmil-images/mine/8b45) | Structure of CC-Tri with Aib@b,c: CC-Tri-(UbUc)4 | 分子名称: | 1,2-ETHANEDIOL, CC-Tri-(UbUc)4, SODIUM ION, ... | 著者 | Kumar, P, Martin, F.J.O, Dawson, W.M, Zieleniewski, F, Woolfson, D.N. | 登録日 | 2022-09-19 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of CC-Tri with Aib@b,c: CC-Tri-(UbUc)4 To Be Published
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2JAM
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![BU of 2jam by Molmil](/molmil-images/mine/2jam) | Crystal structure of human calmodulin-dependent protein kinase I G | 分子名称: | 1,2-ETHANEDIOL, 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, CALCIUM ION, ... | 著者 | Debreczeni, J.E, Bullock, A, Keates, T, Niesen, F.H, Salah, E, Shrestha, L, Smee, C, Sobott, F, Pike, A.C.W, Bunkoczi, G, von Delft, F, Turnbull, A, Weigelt, J, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Knapp, S. | 登録日 | 2006-11-29 | 公開日 | 2007-03-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G To be Published
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7QWE
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![BU of 7qwe by Molmil](/molmil-images/mine/7qwe) | |
7QWB
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![BU of 7qwb by Molmil](/molmil-images/mine/7qwb) | |
7QWA
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2JC6
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![BU of 2jc6 by Molmil](/molmil-images/mine/2jc6) | Crystal structure of human calmodulin-dependent protein kinase 1D | 分子名称: | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1D, N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE | 著者 | Debreczeni, J.E, Rellos, P, Fedorov, O, Niesen, F.H, Bhatia, C, Shrestha, L, Salah, E, Smee, C, Colebrook, S, Berridge, G, Gileadi, O, Bunkoczi, G, Ugochukwu, E, Pike, A.C.W, von Delft, F, Knapp, S, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A. | 登録日 | 2006-12-19 | 公開日 | 2007-02-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Human Calmodulin-Dependent Protein Kinase 1D To be Published
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2JIF
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![BU of 2jif by Molmil](/molmil-images/mine/2jif) | Structure of human short-branched chain acyl-CoA dehydrogenase (ACADSB) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, COENZYME A PERSULFIDE, ... | 著者 | Pike, A.C.W, Hozjan, V, Smee, C, Niesen, F.H, Kavanagh, K.L, Umeano, C, Turnbull, A.P, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C.H, Sundstrom, M, Oppermann, U. | 登録日 | 2007-02-28 | 公開日 | 2007-04-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Human Short-Branched Chain Acyl-Coa Dehydrogenase To be Published
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2IWI
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![BU of 2iwi by Molmil](/molmil-images/mine/2iwi) | CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1 | 分子名称: | RUTHENIUM-PYRIDOCARBAZOLE-1, SERINE/THREONINE-PROTEIN KINASE PIM-2 | 著者 | Russo, S, Debreczeni, J.E, Amos, A, Bullock, A.N, Fedorov, O, Niesen, F, Sobott, F, Turnbull, A, Pike, A.C.W, Ugochukwu, E, Papagrigoriou, E, Bunkoczi, G, Gorrec, F, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, von Delft, F, Knapp, S. | 登録日 | 2006-06-30 | 公開日 | 2006-08-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. PLoS ONE, 4, 2009
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2IW2
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![BU of 2iw2 by Molmil](/molmil-images/mine/2iw2) | Crystal structure of human Prolidase | 分子名称: | SODIUM ION, XAA-PRO DIPEPTIDASE | 著者 | Mueller, U, Niesen, F.H, Roske, Y, Goetz, F, Behlke, J, Buessow, K, Heinemann, U. | 登録日 | 2006-06-24 | 公開日 | 2006-07-05 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease To be Published
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7QWC
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7QWD
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![BU of 7qwd by Molmil](/molmil-images/mine/7qwd) | |