5X9W
 
 | | Mismatch Repair Protein | | Descriptor: | DNA mismatch repair protein MutS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Nair, D.T, Nirwal, S. | | Deposit date: | 2017-03-10 | | Release date: | 2017-11-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Mechanism of formation of a toroid around DNA by the mismatch sensor protein.
Nucleic Acids Res., 46, 2018
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3BJY
 | | Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*DAP*DTP*DCP*DCP*DTP*DCP*DCP*DCP*DCP*DTP*DAP*(DOC))-3'), DNA (5'-D(*DTP*DAP*DAP*(P)P*DGP*DTP*DAP*DGP*DGP*DGP*DGP*DAP*DGP*DGP*DAP*DT)-3'), ... | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2007-12-05 | | Release date: | 2008-10-28 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase
Structure, 16, 2008
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2FLL
 | | Ternary complex of human DNA polymerase iota with DNA and dTTP | | Descriptor: | DNA polymerase iota, DNA primer strand, DNA template strand, ... | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2006-01-06 | | Release date: | 2006-12-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure, 14, 2006
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2FLN
 | | binary complex of catalytic core of human DNA polymerase iota with DNA (template A) | | Descriptor: | DNA polymerase iota, DNA primer strand, DNA template strand | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2006-01-06 | | Release date: | 2006-12-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure, 14, 2006
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1KC5
 | | CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE | | Descriptor: | PC287 Immunoglobulin, PS1 peptide | | Authors: | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V, Salunke, D.M. | | Deposit date: | 2001-11-07 | | Release date: | 2002-07-24 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response.
J.Immunol., 168, 2002
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1KCS
 | | CRYSTAL STRUCTURE OF ANTIBODY PC282 IN COMPLEX WITH PS1 PEPTIDE | | Descriptor: | PC282 IMMUNOGLOBULIN, PS1 peptide | | Authors: | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V.S, Salunke, D.M. | | Deposit date: | 2001-11-11 | | Release date: | 2002-05-11 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response.
J.Immunol., 168, 2002
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1KCU
 | | CRYSTAL STRUCTURE OF ANTIBODY PC287 | | Descriptor: | PC287 IMMUNOGLOBULIN | | Authors: | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V.S, Salunke, D.M. | | Deposit date: | 2001-11-11 | | Release date: | 2002-05-11 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response.
J.Immunol., 168, 2002
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1KCV
 | | Crystal structure of antibody pc282 | | Descriptor: | PC282 IMMUNOGLOBULIN | | Authors: | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V, Salunke, D.M. | | Deposit date: | 2001-11-11 | | Release date: | 2002-05-11 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response.
J.Immunol., 168, 2002
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1T3N
 | | Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP | | Descriptor: | MAGNESIUM ION, Primer DNA strand, THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Nair, D.T, Johnson, R.E, Prakash, S, Prakash, L, Aggarwal, A.K. | | Deposit date: | 2004-04-27 | | Release date: | 2004-07-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.
Nature, 430, 2004
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4IRC
 | | Polymerase-DNA complex | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Nair, D.T, Sharma, A. | | Deposit date: | 2013-01-14 | | Release date: | 2013-04-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli.
Nucleic Acids Res., 41, 2013
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4IRK
 | | structure of Polymerase-DNA complex, dna | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*TP*A*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA (5'-D(*TP*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Nair, D.T, Sharma, A. | | Deposit date: | 2013-01-14 | | Release date: | 2013-04-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli.
Nucleic Acids Res., 41, 2013
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5C5J
 | | Poymerase Nucleotide complex | | Descriptor: | 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase IV, ... | | Authors: | Nair, D.T, Kottur, J. | | Deposit date: | 2015-06-20 | | Release date: | 2016-06-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics
Angew.Chem.Int.Ed.Engl., 55, 2016
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2ALZ
 | | Ternary Complex of hPoli with DNA and dCTP | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*T)-3', ... | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2005-08-08 | | Release date: | 2005-10-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Human DNA Polymerase iota Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair.
Structure, 13, 2005
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2DPJ
 | | structure of hPoli with DNA and dTTP | | Descriptor: | 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(EDA)P*GP*GP*GP*TP*CP*CP*T)-3', DNA polymerase iota, ... | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2006-05-12 | | Release date: | 2006-07-04 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota.
Nat.Struct.Mol.Biol., 13, 2006
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2DPI
 | | Ternary complex of hPoli with DNA and dCTP | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(EDA)P*GP*GP*GP*TP*CP*CP*T)-3', ... | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2006-05-12 | | Release date: | 2006-07-04 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota.
Nat.Struct.Mol.Biol., 13, 2006
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2AQ4
 | | Ternary complex of the catalytic core of REV1 with DNA and dCTP. | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*C)-3', 5'-D(*TP*AP*AP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3', ... | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2005-08-17 | | Release date: | 2005-10-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Rev1 employs a novel mechanism of DNA synthesis using a protein template.
Science, 309, 2005
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2FLP
 | | Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G) | | Descriptor: | DNA polymerase iota, DNA primer strand, DNA template strand | | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | | Deposit date: | 2006-01-06 | | Release date: | 2006-12-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure, 14, 2006
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4DEZ
 | | Structure of MsDpo4 | | Descriptor: | DNA polymerase IV 1 | | Authors: | Nair, D.T, Sharma, A. | | Deposit date: | 2012-01-22 | | Release date: | 2012-08-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The PAD region in the mycobacterial DinB homologue MsPolIV exhibits positional heterogeneity.
Acta Crystallogr.,Sect.D, 68, 2012
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1KCR
 | | CRYSTAL STRUCTURE OF ANTIBODY PC283 IN COMPLEX WITH PS1 PEPTIDE | | Descriptor: | PC283 IMMUNOGLOBULIN, PS1 peptide | | Authors: | Nair, D.T, Singh, K, Sahu, N, Rao, K.V.S, Salunke, D.M. | | Deposit date: | 2001-11-11 | | Release date: | 2002-05-11 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of an antibody bound to an immunodominant peptide epitope: novel features in peptide-antibody recognition.
J.Immunol., 165, 2000
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6JUR
 | | MsDpo4-DNA complex 5 | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (5'-D(*TP*CP*TP*GP*GP*GP*GP*TP*CP*CP*TP*A)-3'), DNA polymerase IV, ... | | Authors: | Nair, D.T, Johnson, M.K. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation.
Nucleic Acids Res., 47, 2019
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6JUN
 | | MsDpo4-DNA complex 3 | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(P*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase IV, ... | | Authors: | Nair, D.T, Johnson, M.K. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation.
Nucleic Acids Res., 47, 2019
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6JUO
 | | MsDpo4-DNA complex 4 | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(P*CP*TP*GP*GP*GP*GP*TP*CP*CP*TP*AP*GP*G)-3'), DNA polymerase IV, ... | | Authors: | Nair, D.T, Johnson, M.K. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation.
Nucleic Acids Res., 47, 2019
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6JUS
 | | MsDpo4-DNA complex 6 | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (5'-D(*TP*CP*TP*GP*GP*GP*GP*TP*CP*CP*TP*AP*G)-3'), DNA polymerase IV, ... | | Authors: | Nair, D.T, Johnson, M.K. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation.
Nucleic Acids Res., 47, 2019
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6JUL
 | | MsDpo4-DNA complex 1 | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(P*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase IV, ... | | Authors: | Nair, D.T, Johnson, M.K. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-19 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation.
Nucleic Acids Res., 47, 2019
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6JUQ
 | | mutant PolIV-DNA incoming nucleotide complex 2 | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (5'-D(P*CP*TP*GP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Nair, D.T, Johnson, M.K. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation.
Nucleic Acids Res., 47, 2019
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