5BPK
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![BU of 5bpk by Molmil](/molmil-images/mine/5bpk) | Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases | Descriptor: | (2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid, 1,2-ETHANEDIOL, Gamma-glutamyltranspeptidase (Ggt) | Authors: | Bolz, C, Bach, N.C, Meyer, H, Mueller, G, Dawidowski, M, Popowicz, G, Sieber, S.A, Skerra, A, Gerhard, M. | Deposit date: | 2015-05-28 | Release date: | 2016-05-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases To Be Published
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4Q5R
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4Q5Q
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4Q5N
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4Q5F
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4KSE
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![BU of 4kse by Molmil](/molmil-images/mine/4kse) | Crystal structure of a HIV p51 (219-230) deletion mutant | Descriptor: | 1,2-ETHANEDIOL, HIV p51 subunit | Authors: | Zheng, X, Mueller, G.A, Derose, E.F, Pedersen, L.C, Gabel, S.A, Cuneo, M.J, Krahn, J.M, London, R.E. | Deposit date: | 2013-05-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.677 Å) | Cite: | Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation. Nucleic Acids Res., 42, 2014
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6XRX
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![BU of 6xrx by Molmil](/molmil-images/mine/6xrx) | Crystal structure of the mosquito protein AZ1 as an MBP fusion | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein, ... | Authors: | Pedersen, L.C, Mueller, G.A, Foo, A.C.Y. | Deposit date: | 2020-07-14 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism. Proc.Natl.Acad.Sci.USA, 118, 2021
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1PV3
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![BU of 1pv3 by Molmil](/molmil-images/mine/1pv3) | NMR Solution Structure of the Avian FAT-domain of Focal Adhesion Kinase | Descriptor: | Focal adhesion kinase 1 | Authors: | Prutzman, K.C, Gao, G, King, M.L, Iyer, V.V, Mueller, G.A, Schaller, M.D, Campbell, S.L. | Deposit date: | 2003-06-26 | Release date: | 2004-05-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The Focal Adhesion Targeting Domain of Focal Adhesion Kinase Contains a Hinge Region that Modulates Tyrosine 926 Phosphorylation. STRUCTURE, 12, 2004
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1J57
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![BU of 1j57 by Molmil](/molmil-images/mine/1j57) | NuiA | Descriptor: | NuiA | Authors: | Kirby, T.W, Mueller, G.A, DeRose, E.F, Lebetkin, M.S, Meiss, G, Pingoud, A, London, R.E. | Deposit date: | 2002-01-17 | Release date: | 2002-12-04 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The Nuclease A Inhibitor represents a new variation of the rare PR-1 fold. J.Mol.Biol., 320, 2002
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3H4Z
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![BU of 3h4z by Molmil](/molmil-images/mine/3h4z) | Crystal Structure of an MBP-Der p 7 fusion protein | Descriptor: | Maltose-binding periplasmic protein fused with Allergen DERP7, SODIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Pedersen, L.C, Mueller, G.A, London, R.E. | Deposit date: | 2009-04-21 | Release date: | 2010-03-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. J.Allergy Clin.Immunol., 125, 2010
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1NZP
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![BU of 1nzp by Molmil](/molmil-images/mine/1nzp) | Solution Structure of the Lyase Domain of Human DNA Polymerase Lambda | Descriptor: | DNA polymerase lambda | Authors: | DeRose, E.F, Kirby, T.W, Mueller, G.A, Bebenek, K, Garcia-Diaz, M, Blanco, L, Kunkel, T.A, London, R.E. | Deposit date: | 2003-02-19 | Release date: | 2003-08-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Lyase Domain of Human DNA Polymerase Lambda Biochemistry, 42, 2003
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8SCH
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![BU of 8sch by Molmil](/molmil-images/mine/8sch) | TCEI_III NMR Structure | Descriptor: | RNA (68-MER) | Authors: | Warden, M.S, Mueller, G.A, Hall, T.M.T. | Deposit date: | 2023-04-05 | Release date: | 2023-07-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR, SOLUTION SCATTERING | Cite: | The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos. Nucleic Acids Res., 51, 2023
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8SCF
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![BU of 8scf by Molmil](/molmil-images/mine/8scf) | TCEIII NMR Structure | Descriptor: | RNA (30-MER) | Authors: | Warden, M.S, Mueller, G.A, Hall, T.M.T. | Deposit date: | 2023-04-05 | Release date: | 2023-07-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos. Nucleic Acids Res., 51, 2023
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4EHQ
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![BU of 4ehq by Molmil](/molmil-images/mine/4ehq) | Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode | Descriptor: | CALCIUM ION, Calcium release-activated calcium channel protein 1, Calmodulin, ... | Authors: | Liu, Y, Zheng, X, Mueller, G.A, Sobhany, M, DeRose, E.F, Zhang, Y, London, R.E, Birnbaumer, L. | Deposit date: | 2012-04-03 | Release date: | 2012-11-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9005 Å) | Cite: | Crystal structure of calmodulin binding domain of orai1 in complex with ca2+*calmodulin displays a unique binding mode. J.Biol.Chem., 287, 2012
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1O1W
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![BU of 1o1w by Molmil](/molmil-images/mine/1o1w) | SOLUTION STRUCTURE OF THE RNASE H DOMAIN OF THE HIV-1 REVERSE TRANSCRIPTASE IN THE PRESENCE OF MAGNESIUM | Descriptor: | RIBONUCLEASE H | Authors: | Pari, K, Mueller, G.A, Derose, E.F, Kirby, T.W, London, R.E. | Deposit date: | 2003-02-12 | Release date: | 2003-02-18 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Rnase H Domain of the HIV-1 Reverse Transcriptase in the Presence of Magnesium Biochemistry, 42, 2003
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1Z0R
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![BU of 1z0r by Molmil](/molmil-images/mine/1z0r) | Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB | Descriptor: | Transition state regulatory protein abrB | Authors: | Bobay, B.G, Andreeva, A, Mueller, G.A, Cavanagh, J, Murzin, A.G. | Deposit date: | 2005-03-02 | Release date: | 2005-03-15 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. Febs Lett., 579, 2005
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2KTE
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![BU of 2kte by Molmil](/molmil-images/mine/2kte) | The solution structure of Bacillus subtilis, YndB, Northeast Structural Genomics Consoritum Target SR211 | Descriptor: | Uncharacterized protein yndB | Authors: | Mercier, K.A, Mueller, G.A, Powers, R, Acton, T.B, Ciano, M, Ho, C, Lui, J, Ma, L, Rost, B, Rossi, R, Montelione, G.T, Xiao, R, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-01-29 | Release date: | 2010-06-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. Proteins, 78, 2010
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2KEW
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![BU of 2kew by Molmil](/molmil-images/mine/2kew) | The solution structure of Bacillus subtilis SR211 START domain by NMR spectroscopy | Descriptor: | Uncharacterized protein yndB | Authors: | Mercier, K.A, Mueller, G.A, Powers, R, Acton, T.B, Ciano, M, Ho, C, Lui, J, Ma, L, Rost, B, Rossi, R, Xiao, R, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-02-05 | Release date: | 2009-03-17 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | (1)H, (13)C, and (15)N NMR assignments for the Bacillus subtilis yndB START domain. Biomol.Nmr Assign., 3, 2009
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2VKY
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![BU of 2vky by Molmil](/molmil-images/mine/2vky) | Headbinding Domain of Phage P22 Tailspike C-Terminally Fused to Isoleucine Zipper pIIGCN4 (Chimera I) | Descriptor: | TAIL PROTEIN, PIIGCN4 | Authors: | Seul, A, Mueller, J.J, Mueller, G, Heinemann, U, Seckler, R. | Deposit date: | 2008-01-04 | Release date: | 2009-02-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Bacteriophage P22 Tailspike: Structure of the Complete Protein and Function of the Interdomain Linker Acta Crystallogr.,Sect.D, 70, 2014
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2VNL
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![BU of 2vnl by Molmil](/molmil-images/mine/2vnl) | MUTANT Y108Wdel OF THE HEADBINDING DOMAIN OF PHAGE P22 TAILSPIKE C- TERMINally fused to ISOLEUCINE ZIPPER pIIGCN4 (chimera II) | Descriptor: | BIFUNCTIONAL TAIL PROTEIN, PIIGCN4, GLYCEROL | Authors: | Mueller, J.J, Seul, A, Mueller, G, Seckler, R, Heinemann, U. | Deposit date: | 2008-02-05 | Release date: | 2009-02-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Bacteriophage P22 Tailspike: Structure of the Complete Protein and Function of the Interdomain Linker Acta Crystallogr.,Sect.D, 70, 2014
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1SE7
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![BU of 1se7 by Molmil](/molmil-images/mine/1se7) | Solution structure of the E. coli bacteriophage P1 encoded HOT protein: a homologue of the theta subunit of E. coli DNA polymerase III | Descriptor: | HOMOLOGUE OF THE THETA SUBUNIT OF DNA POLYMERASE III | Authors: | DeRose, E.F, Kirby, T.W, Mueller, G.A, Chikova, A.K, Schaaper, R.M, London, R.E. | Deposit date: | 2004-02-16 | Release date: | 2004-12-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Phage Like It HOT: Solution Structure of the Bacteriophage P1-Encoded HOT Protein, a Homolog of the theta Subunit of E. coli DNA Polymerase III Structure, 12, 2004
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2HTF
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![BU of 2htf by Molmil](/molmil-images/mine/2htf) | The solution structure of the BRCT domain from human polymerase reveals homology with the TdT BRCT domain | Descriptor: | DNA polymerase mu | Authors: | DeRose, E.F, Clarkson, M.W, Gilmore, S.A, Ramsden, D.A, Mueller, G.A, London, R.E, Lee, A.L. | Deposit date: | 2006-07-25 | Release date: | 2007-02-27 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining. Biochemistry, 46, 2007
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4ZCE
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![BU of 4zce by Molmil](/molmil-images/mine/4zce) | Crystal Structure of the dust mite allergen Der p 23 from Dermatophagoides pteronyssinus | Descriptor: | 1,2-ETHANEDIOL, Dust mite allergen | Authors: | Pedersen, L.C, Mueller, G.A, Randall, T.A, Glesner, J, Perera, L, Edwards, L.L, Chapman, M.D, London, R.E, Pomes, A. | Deposit date: | 2015-04-15 | Release date: | 2015-11-25 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Serological, genomic and structural analyses of the major mite allergen Der p 23. Clin Exp Allergy, 46, 2016
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7NTH
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![BU of 7nth by Molmil](/molmil-images/mine/7nth) | Structure of TAK1 in complex with compound 54 | Descriptor: | 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{R})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{H}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | Deposit date: | 2021-03-09 | Release date: | 2021-04-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7NTI
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![BU of 7nti by Molmil](/molmil-images/mine/7nti) | Structure of TAK1 in complex with compound 22 | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, ... | Authors: | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | Deposit date: | 2021-03-09 | Release date: | 2021-04-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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