6I2I
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6YW6
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![BU of 6yw6 by Molmil](/molmil-images/mine/6yw6) | Cryo-EM structure of the ARP2/3 1B5CL isoform complex. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ARPC1B, Actin-related protein 2, ... | 著者 | von Loeffelholz, O, Moores, C, Purkiss, A. | 登録日 | 2020-04-29 | 公開日 | 2020-07-22 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Biol Open, 9, 2020
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6YW7
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![BU of 6yw7 by Molmil](/molmil-images/mine/6yw7) | Cryo-EM structure of the ARP2/3 1A5C isoform complex. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ... | 著者 | von Loeffelholz, O, Moores, C, Purkiss, A. | 登録日 | 2020-04-29 | 公開日 | 2020-07-22 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Biol Open, 9, 2020
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7Z2C
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![BU of 7z2c by Molmil](/molmil-images/mine/7z2c) | P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | 登録日 | 2022-02-26 | 公開日 | 2022-10-19 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
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7Z2A
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![BU of 7z2a by Molmil](/molmil-images/mine/7z2a) | P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | 登録日 | 2022-02-26 | 公開日 | 2022-10-19 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
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7Z2B
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![BU of 7z2b by Molmil](/molmil-images/mine/7z2b) | P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | 登録日 | 2022-02-26 | 公開日 | 2022-11-16 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
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4UXT
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![BU of 4uxt by Molmil](/molmil-images/mine/4uxt) | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN HEAVY CHAIN ISOFORM 5A, ... | 著者 | Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C. | 登録日 | 2014-08-27 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | 主引用文献 | Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins. Elife, 3, 2014
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6QVE
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![BU of 6qve by Molmil](/molmil-images/mine/6qve) | NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule | 分子名称: | Beta1-tubulin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | 登録日 | 2019-03-01 | 公開日 | 2019-11-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nat Commun, 10, 2019
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6QUY
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![BU of 6quy by Molmil](/molmil-images/mine/6quy) | NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule | 分子名称: | CKK domain protein, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | 登録日 | 2019-02-28 | 公開日 | 2019-11-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nat Commun, 10, 2019
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6QVJ
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![BU of 6qvj by Molmil](/molmil-images/mine/6qvj) | HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule | 分子名称: | Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | 登録日 | 2019-03-02 | 公開日 | 2019-11-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nat Commun, 10, 2019
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6QUS
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![BU of 6qus by Molmil](/molmil-images/mine/6qus) | HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule | 分子名称: | Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | 登録日 | 2019-02-28 | 公開日 | 2019-11-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nat Commun, 10, 2019
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5MJS
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4ATX
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![BU of 4atx by Molmil](/molmil-images/mine/4atx) | Rigor kinesin motor domain with an ordered neck-linker, docked on tubulin dimer, modelled into the 8A cryo-EM map of doublecortin- microtubules decorated with kinesin | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-1 HEAVY CHAIN, ... | 著者 | Liu, J.S, Schubert, C.R, Fu, X, Fourniol, F.J, Jaiswal, J.K, Houdusse, A, Stultz, C.M, Moores, C.A, Walsh, C.A. | 登録日 | 2012-05-10 | 公開日 | 2012-09-26 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins. Mol.Cell, 47, 2012
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4AQW
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![BU of 4aqw by Molmil](/molmil-images/mine/4aqw) | Model of human kinesin-5 motor domain (1II6, 3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.5-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the rigor state. | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | 著者 | Goulet, A, Behnke-Parks, W.M, Sindelar, C.V, Rosenfeld, S.S, Moores, C.A. | 登録日 | 2012-04-19 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9.5 Å) | 主引用文献 | The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5. J.Biol.Chem., 287, 2012
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7NBA
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![BU of 7nba by Molmil](/molmil-images/mine/7nba) | Plasmodium falciparum kinesin-5 motor domain bound to AMPPNP, complexed with 14 protofilament microtubule. | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin motor domain-containing protein,Kinesin motor domain-containing protein, MAGNESIUM ION, ... | 著者 | Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A. | 登録日 | 2021-01-25 | 公開日 | 2021-10-13 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition. J.Biol.Chem., 297, 2021
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4AQV
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![BU of 4aqv by Molmil](/molmil-images/mine/4aqv) | Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state. | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | 著者 | Goulet, A, Behnke-Parks, W.M, Sindelar, C.V, Rosenfeld, S.S, Moores, C.A. | 登録日 | 2012-04-19 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9.7 Å) | 主引用文献 | The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5. J.Biol.Chem., 287, 2012
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7NB8
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![BU of 7nb8 by Molmil](/molmil-images/mine/7nb8) | Plasmodium falciparum kinesin-5 motor domain without nucleotide, complexed with 14 protofilament microtubule. | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-5, MAGNESIUM ION, ... | 著者 | Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A. | 登録日 | 2021-01-25 | 公開日 | 2021-10-13 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition. J.Biol.Chem., 297, 2021
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4ATU
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![BU of 4atu by Molmil](/molmil-images/mine/4atu) | Human doublecortin N-DC repeat plus linker, and tubulin (2XRP) docked into an 8A cryo-EM map of doublecortin-stabilised microtubules reconstructed in absence of kinesin | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, NEURONAL MIGRATION PROTEIN DOUBLECORTIN, ... | 著者 | Liu, J.S, Schubert, C.R, Fu, X, Fourniol, F.J, Jaiswal, J.K, Houdusse, A, Stultz, C.M, Moores, C.A, Walsh, C.A. | 登録日 | 2012-05-09 | 公開日 | 2012-09-26 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (8.3 Å) | 主引用文献 | Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins. Mol.Cell, 47, 2012
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5N5N
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![BU of 5n5n by Molmil](/molmil-images/mine/5n5n) | Cryo-EM structure of tsA201 cell alpha1B and betaI and betaIVb microtubules | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | 著者 | Vemu, A, Atherton, J, Spector, J.O, Moores, C.A, Roll-Mecak, A. | 登録日 | 2017-02-14 | 公開日 | 2017-11-01 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Tubulin isoform composition tunes microtubule dynamics. Mol. Biol. Cell, 28, 2017
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5ND4
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![BU of 5nd4 by Molmil](/molmil-images/mine/5nd4) | Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. | 登録日 | 2017-03-07 | 公開日 | 2017-10-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
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4CK6
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![BU of 4ck6 by Molmil](/molmil-images/mine/4ck6) | Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP.AlFx state, based on cryo-electron microscopy experiment. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | 登録日 | 2013-12-30 | 公開日 | 2014-02-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9.2 Å) | 主引用文献 | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CK7
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![BU of 4ck7 by Molmil](/molmil-images/mine/4ck7) | Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in presence of adp.alfx (NECK-LINKER IN ITS DISCONNECTED CONFORMATION, based on cryo-electron microscopy experiment | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | 登録日 | 2013-12-30 | 公開日 | 2014-02-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9.2 Å) | 主引用文献 | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CK5
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![BU of 4ck5 by Molmil](/molmil-images/mine/4ck5) | Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP state, based on cryo-electron microscopy experiment. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | 登録日 | 2013-12-30 | 公開日 | 2014-02-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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5M5I
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![BU of 5m5i by Molmil](/molmil-images/mine/5m5i) | Pseudo-atomic model of microtubule-bound S.pombe kinesin-5 motor domain in the AMPPNP state (based on cryo-electron microscopy experiment): the N-terminus conformation allows formation of a cover neck bundle. | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein cut7, ... | 著者 | Goulet, A, Moores, C.A, Cross, R.A. | 登録日 | 2016-10-21 | 公開日 | 2016-11-30 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | 主引用文献 | Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5M5N
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![BU of 5m5n by Molmil](/molmil-images/mine/5m5n) | Pseudo-atomic model of microtubule-bound S.pombe kinesin-5 motor domain in the AMPPNP state (based on cryo-electron microscopy experiment): the N-terminus adopts multiple conformations. | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein cut7, ... | 著者 | Goulet, A, Moores, C.A, Cross, R.A. | 登録日 | 2016-10-22 | 公開日 | 2016-11-30 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | 主引用文献 | Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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