1TTC
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1TTA
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1FKO
| CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) | 分子名称: | (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, HIV-1 RT, A-CHAIN, ... | 著者 | Ren, J, Milton, J, Weaver, K.L, Short, S.A, Stuart, D.I, Stammers, D.K. | 登録日 | 2000-08-10 | 公開日 | 2000-11-03 | 最終更新日 | 2018-03-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase. Structure Fold.Des., 8, 2000
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1FK9
| CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) | 分子名称: | (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, HIV-1 RT, A-CHAIN, ... | 著者 | Ren, J, Milton, J, Weaver, K.L, Short, S.A, Stuart, D.I, Stammers, D.K. | 登録日 | 2000-08-09 | 公開日 | 2000-11-03 | 最終更新日 | 2017-02-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase. STRUCTURE FOLD.DES., 8, 2000
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1FKP
| CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE | 分子名称: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 RT, A-CHAIN, ... | 著者 | Ren, J, Milton, J, Weaver, K.L, Short, S.A, Stuart, D.I, Stammers, D.K. | 登録日 | 2000-08-10 | 公開日 | 2000-11-03 | 最終更新日 | 2018-03-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase. Structure Fold.Des., 8, 2000
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1DTT
| CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94) | 分子名称: | HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-CHLORO-PYRIDYL]-THIOUREA | 著者 | Ren, J, Diprose, J, Warren, J, Esnouf, R.M, Bird, L.E, Ikemizu, S, Slater, M, Milton, J, Balzarini, J, Stuart, D.I, Stammers, D.K. | 登録日 | 2000-01-13 | 公開日 | 2000-04-02 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. J.Biol.Chem., 275, 2000
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1DTQ
| CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94) | 分子名称: | HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-NITRILOMETHYL-PYRIDYL]-THIOUREA | 著者 | Ren, J, Diprose, J, Warren, J, Esnouf, R.M, Bird, L.E, Ikemizu, S, Slater, M, Milton, J, Balzarini, J, Stuart, D.I, Stammers, D.K. | 登録日 | 2000-01-13 | 公開日 | 2000-03-20 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. J.Biol.Chem., 275, 2000
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3IFB
| NMR STUDY OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN | 分子名称: | INTESTINAL FATTY ACID BINDING PROTEIN | 著者 | Zhang, F, Luecke, C, Baier, L.J, Sacchettini, J.C, Hamilton, J.A. | 登録日 | 1998-10-16 | 公開日 | 1998-10-21 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. J.Biomol.NMR, 9, 1997
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6ZPR
| Solution structure of MLKL executioner domain in complex with a covalent inhibitor | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2020-07-09 | 公開日 | 2020-12-16 | 最終更新日 | 2021-01-06 | 実験手法 | SOLUTION NMR | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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7NM5
| Solution structure of MLKL executioner domain in complex with a fragment | 分子名称: | 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2021-02-23 | 公開日 | 2021-09-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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7NM2
| Solution structure of MLKL executioner domain in complex with a fragment | 分子名称: | 2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2021-02-23 | 公開日 | 2021-09-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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7NM4
| Solution structure of MLKL executioner domain in complex with a fragment | 分子名称: | (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol, Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2021-02-23 | 公開日 | 2021-09-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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1KZX
| Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) | 分子名称: | INTESTINAL FATTY ACID-BINDING PROTEIN (T54) | 著者 | Zhang, F, Luecke, C, Baier, L.J, Sacchettini, J.C, Hamilton, J.A. | 登録日 | 2002-02-08 | 公開日 | 2003-07-01 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism Biochemistry, 42, 2003
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1KZW
| Solution structure of Human Intestinal Fatty acid binding protein | 分子名称: | INTESTINAL FATTY ACID-BINDING PROTEIN (A54) | 著者 | Zhang, F, Luecke, C, Baier, L.J, Sacchettini, J.C, Hamilton, J.A. | 登録日 | 2002-02-08 | 公開日 | 2003-07-01 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism Biochemistry, 42, 2003
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3OD1
| The crystal structure of an ATP phosphoribosyltransferase regulatory subunit/histidyl-tRNA synthetase from Bacillus halodurans C | 分子名称: | ATP phosphoribosyltransferase regulatory subunit, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER | 著者 | Tan, K, Bigelow, L, Hamilton, J, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2010-08-10 | 公開日 | 2010-08-25 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | The crystal structure of aATP phosphoribosyltransferase regulatory subunit/histidyl-tRNA synthetase from Bacillus halodurans C To be Published
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1U5M
| Structure of a Chordin-like Cysteine-rich Repeat (VWC module) from Collagen IIA | 分子名称: | alpha 1 type II collagen isoform 1 | 著者 | O'Leary, J.M, Hamilton, J.m, Deane, C.M, Valeyev, N.V, Sandell, L.J, Downing, A.K. | 登録日 | 2004-07-28 | 公開日 | 2004-10-05 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and dynamics of a prototypical chordin-like cysteine-rich repeat (von Willebrand Factor type C module) from collagen IIA J.Biol.Chem., 279, 2004
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1ETB
| THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN | 著者 | Braden, B.C, Steinrauf, L.K, Hamilton, J.A. | 登録日 | 1993-05-12 | 公開日 | 1995-01-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. J.Biol.Chem., 268, 1993
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2FLJ
| Fatty acid binding protein from locust flight muscle in complex with oleate | 分子名称: | Fatty acid-binding protein, OLEIC ACID | 著者 | Luecke, C, Qiao, Y, van Moerkerk, H.T.B, Veerkamp, J.H, Hamilton, J.A. | 登録日 | 2006-01-06 | 公開日 | 2006-05-23 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | Fatty-acid-binding protein from the flight muscle of Locusta migratoria: evolutionary variations in fatty acid binding. Biochemistry, 45, 2006
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1TTB
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1ETA
| THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN | 著者 | Braden, B.C, Steinrauf, L.K, Hamilton, J.A. | 登録日 | 1993-05-12 | 公開日 | 1995-01-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. J.Biol.Chem., 268, 1993
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1EAL
| NMR STUDY OF ILEAL LIPID BINDING PROTEIN | 分子名称: | ILEAL LIPID BINDING PROTEIN | 著者 | Luecke, C, Zhang, F, Rueterjans, H, Hamilton, J.A, Sacchettini, J.C. | 登録日 | 1996-08-28 | 公開日 | 1997-01-22 | 最終更新日 | 2022-02-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. Structure, 4, 1996
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1JM6
| Pyruvate dehydrogenase kinase, isozyme 2, containing ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pyruvate dehydrogenase kinase, ... | 著者 | Steussy, C.N, Popov, K.M, Bowker-Kinley, M.M, Sloan, R.B, Harris, R.A, Hamilton, J.A. | 登録日 | 2001-07-17 | 公開日 | 2001-10-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase. J.Biol.Chem., 276, 2001
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1EIO
| ILEAL LIPID BINDING PROTEIN IN COMPLEX WITH GLYCOCHOLATE | 分子名称: | GLYCOCHOLIC ACID, ILEAL LIPID BINDING PROTEIN | 著者 | Luecke, C, Zhang, F, Hamilton, J.A, Sacchettini, J.C, Rueterjans, H. | 登録日 | 2000-02-27 | 公開日 | 2000-05-31 | 最終更新日 | 2022-02-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of ileal lipid binding protein in complex with glycocholate. Eur.J.Biochem., 267, 2000
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3HUD
| THE STRUCTURE OF HUMAN BETA 1 BETA 1 ALCOHOL DEHYDROGENASE: CATALYTIC EFFECTS OF NON-ACTIVE-SITE SUBSTITUTIONS | 分子名称: | ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | 著者 | Hurley, T.D, Bosron, W.F, Hamilton, J.A, Amzel, L.M. | 登録日 | 1993-01-04 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Proc.Natl.Acad.Sci.USA, 88, 1991
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3OOS
| The structure of an alpha/beta fold family hydrolase from Bacillus anthracis str. Sterne | 分子名称: | Alpha/beta hydrolase family protein, GLYCEROL, SULFATE ION, ... | 著者 | Fan, Y, Tan, K, Bigelow, L, Hamilton, J, Li, H, Zhou, Y, Clancy, S, Buck, K, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2010-08-31 | 公開日 | 2010-11-10 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The structure of an alpha/beta fold family hydrolase from Bacillus anthracis str. Sterne To be Published
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