1GVN
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![BU of 1gvn by Molmil](/molmil-images/mine/1gvn) | Crystal Structure of the Plasmid Maintenance System epsilon/zeta: Meachnism of toxin inactivation and toxin function | Descriptor: | EPSILON, SULFATE ION, ZETA | Authors: | Meinhart, A, Alonso, J.C, Straeter, N, Saenger, W. | Deposit date: | 2002-02-19 | Release date: | 2003-01-29 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the Plasmid Maintenance System Epsilon /Zeta : Functional Mechanism of Toxin Zeta and Inactivation by Epsilon 2 Zeta 2 Complex Formation Proc.Natl.Acad.Sci.USA, 100, 2003
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6ZK7
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![BU of 6zk7 by Molmil](/molmil-images/mine/6zk7) | Crystal Structure of human PYROXD1/FAD complex | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | Authors: | Meinhart, A, Asanovic, I, Martinez, J, Clausen, T. | Deposit date: | 2020-06-30 | Release date: | 2021-05-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Mol.Cell, 81, 2021
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1Q1H
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7AA4
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![BU of 7aa4 by Molmil](/molmil-images/mine/7aa4) | Structure of ClpC1-NTD bound to a CymA analogue | Descriptor: | Negative regulator of genetic competence ClpC/mecB, polymer Cyclomarin A analogue | Authors: | Meinhart, A, Morreale, F.E, Kaiser, M, Clausen, T. | Deposit date: | 2020-09-03 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | BacPROTACs mediate targeted protein degradation in bacteria. Cell, 185, 2022
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6QDJ
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![BU of 6qdj by Molmil](/molmil-images/mine/6qdj) | Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin | Descriptor: | 1,4-BUTANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Meinhart, A, Clausen, T, Arnese, R. | Deposit date: | 2019-01-02 | Release date: | 2019-10-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.884 Å) | Cite: | Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin. Nat Commun, 10, 2019
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6QDM
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6QDL
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![BU of 6qdl by Molmil](/molmil-images/mine/6qdl) | |
6QDK
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1SZA
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![BU of 1sza by Molmil](/molmil-images/mine/1sza) | |
1SZ9
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![BU of 1sz9 by Molmil](/molmil-images/mine/1sz9) | |
8B9O
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![BU of 8b9o by Molmil](/molmil-images/mine/8b9o) | |
8B9U
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6EPH
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![BU of 6eph by Molmil](/molmil-images/mine/6eph) | Structure of the epsilon_1 / zeta_1 antitoxin toxin system from Neisseria gonorrhoeae in complex with UNAM. | Descriptor: | (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, CITRATE ANION, Epsilon_1 antitoxin, ... | Authors: | Rocker, A, Meinhart, A. | Deposit date: | 2017-10-11 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The ng_ zeta 1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis. Nat Commun, 9, 2018
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3D9J
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![BU of 3d9j by Molmil](/molmil-images/mine/3d9j) | Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II | Descriptor: | AMMONIUM ION, GLYCEROL, RNA-binding protein 16, ... | Authors: | Becker, R, Loll, B, Meinhart, A. | Deposit date: | 2008-05-27 | Release date: | 2008-06-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Snapshots of the RNA Processing Factor SCAF8 Bound to Different Phosphorylated Forms of the Carboxyl-terminal Domain of RNA Polymerase II. J.Biol.Chem., 283, 2008
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3D9I
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![BU of 3d9i by Molmil](/molmil-images/mine/3d9i) | Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the Carboxy-Terminal Domain of RNA-Polymerase II | Descriptor: | AMMONIUM ION, GLYCEROL, RNA-binding protein 16, ... | Authors: | Becker, R, Loll, B, Meinhart, A. | Deposit date: | 2008-05-27 | Release date: | 2008-06-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.907 Å) | Cite: | Snapshots of the RNA Processing Factor SCAF8 Bound to Different Phosphorylated Forms of the Carboxyl-terminal Domain of RNA Polymerase II. J.Biol.Chem., 283, 2008
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3D9N
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3D9K
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6TV6
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![BU of 6tv6 by Molmil](/molmil-images/mine/6tv6) | Octameric McsB from Bacillus subtilis. | Descriptor: | MAGNESIUM ION, Protein-arginine kinase | Authors: | Suskiewicz, M.J, Hajdusits, B, Meinhart, A, Clausen, T. | Deposit date: | 2020-01-09 | Release date: | 2021-07-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. Elife, 10, 2021
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7QVE
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![BU of 7qve by Molmil](/molmil-images/mine/7qve) | Spinach 20S proteasome | Descriptor: | Proteasome subunit alpha type, Proteasome subunit alpha type-3, Proteasome subunit beta, ... | Authors: | Kandolf, S, Grishkovskaya, I, Meinhart, A, Haselbach, D. | Deposit date: | 2022-01-21 | Release date: | 2022-05-25 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of the plant 26S proteasome. Plant Commun., 3, 2022
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4XW3
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![BU of 4xw3 by Molmil](/molmil-images/mine/4xw3) | |
3ISM
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![BU of 3ism by Molmil](/molmil-images/mine/3ism) | Crystal structure of the EndoG/EndoGI complex: Mechanism of EndoG inhibition | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CG4930, CG8862, ... | Authors: | Loll, B, Gebhardt, M, Wahle, E, Meinhart, A. | Deposit date: | 2009-08-26 | Release date: | 2009-09-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition. Nucleic Acids Res., 37, 2009
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3Q8X
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![BU of 3q8x by Molmil](/molmil-images/mine/3q8x) | Structure of a toxin-antitoxin system bound to its substrate | Descriptor: | Antidote of epsilon-zeta postsegregational killing system, SULFATE ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ... | Authors: | Mutschler, H, Gebhardt, M, Shoeman, R.L, Meinhart, A. | Deposit date: | 2011-01-07 | Release date: | 2011-03-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. Plos Biol., 9, 2011
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3CLJ
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![BU of 3clj by Molmil](/molmil-images/mine/3clj) | Structure of the RNA polymerase II CTD-interacting domain of Nrd1 | Descriptor: | GLYCEROL, Protein NRD1, SULFATE ION | Authors: | Vasiljeva, L, Kim, M, Mutschler, H, Buratowski, S, Meinhart, A. | Deposit date: | 2008-03-19 | Release date: | 2008-07-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain. Nat.Struct.Mol.Biol., 15, 2008
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2P5T
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6TAY
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![BU of 6tay by Molmil](/molmil-images/mine/6tay) | Mouse RNF213 mutant R4753K modeling the Moyamoya-disease-related Human variant R4810K | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ... | Authors: | Ahel, J, Meinhart, A, Haselbach, D, Clausen, T. | Deposit date: | 2019-10-31 | Release date: | 2020-07-01 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife, 9, 2020
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