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PDB: 177 results
4ZYK
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BU of 4zyk by Molmil
Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, AM14 Fab heavy chain, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2015-05-21
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.
Plos Pathog., 11, 2015
8T7A
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BU of 8t7a by Molmil
Cryo-EM structure of RSV preF in complex with Fab 2.4K
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2.4K Fab Heavy Chain, 2.4K Fab Light Chain, ...
Authors:McCool, R.S, McLellan, J.S.
Deposit date:2023-06-20
Release date:2023-09-13
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein elicits antibodies targeting a membrane-proximal epitope.
J.Virol., 97, 2023
8TMA
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BU of 8tma by Molmil
Antibody N3-1 bound to RBD in the up conformation
Descriptor: N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2023-07-29
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode.
Commun Biol, 6, 2023
8TM1
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BU of 8tm1 by Molmil
Antibody N3-1 bound to RBDs in the up and down conformations
Descriptor: N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2023-07-27
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode.
Commun Biol, 6, 2023
6OE5
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BU of 6oe5 by Molmil
Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs
Descriptor: CR9501 Fab Heavy Chain, CR9501 Fab Light Chain, Fusion glycoprotein F0,Fibritin, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2019-03-27
Release date:2019-04-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Transient opening of trimeric prefusion RSV F proteins.
Nat Commun, 10, 2019
8U1R
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BU of 8u1r by Molmil
Prefusion-stabilized Langya virus F protein, variant G99C/I109C
Descriptor: Fusion glycoprotein F
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2023-09-01
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Prefusion-stabilized Langya virus F protein, variant G99C/I109C
To Be Published
8U1G
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BU of 8u1g by Molmil
Prefusion-stabilized SARS-CoV-2 S2 subunit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2023-08-31
Release date:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of prefusion-stabilized SARS-CoV-2 S2-only antigen
To Be Published
8TW3
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BU of 8tw3 by Molmil
hMPV fusion protein complexed with single domain antibodies sdHMPV16 and sdHMPV12
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein, Single domain antibody sdHMPV12, ...
Authors:Rush, S.A, McLellan, J.S.
Deposit date:2023-08-19
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein.
Mbio, 15, 2024
8V5K
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BU of 8v5k by Molmil
Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Camelid Nanobody 4C03, Camelid Nanobody 4C06, ...
Authors:Johnson, N.V, Ramamohan, A.R, McLellan, J.S.
Deposit date:2023-11-30
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies.
Nat Commun, 15, 2024
8V62
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BU of 8v62 by Molmil
Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06
Descriptor: Camelid nanobody 1D10, Camelid nanobody 4C06, Fusion glycoprotein F0
Authors:Johnson, N.J, Ramamohan, A.R, McLellan, J.S.
Deposit date:2023-12-01
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies.
Nat Commun, 15, 2024
6PXG
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BU of 6pxg by Molmil
Crystal Structure of MERS-CoV neutralizing antibody G2 Fab
Descriptor: G2 Fab Heavy Chain, G2 Fab Light chain
Authors:Wang, N, McLellan, J.S.
Deposit date:2019-07-26
Release date:2019-09-25
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.
Cell Rep, 28, 2019
8V5A
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BU of 8v5a by Molmil
Prefusion-stabilized Respirovirus type 3 Fusion protein
Descriptor: Camelid nanobody 4C06, Fusion glycoprotein F0
Authors:Johnson, N.V, McLellan, J.S.
Deposit date:2023-11-30
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein.
Nat Commun, 15, 2024
6PXH
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BU of 6pxh by Molmil
Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIHYDROFOLIC ACID, ...
Authors:Wang, N, McLellan, J.S.
Deposit date:2019-07-26
Release date:2019-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.
Cell Rep, 28, 2019
6PZK
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BU of 6pzk by Molmil
Cryo-EM Structure of the Respiratory Syncytial Virus Polymerase (L) Protein Bound by the Tetrameric Phosphoprotein (P)
Descriptor: Phosphoprotein, RNA-directed RNA polymerase L
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2019-08-01
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the Respiratory Syncytial Virus Polymerase Complex.
Cell, 179, 2019
8TCO
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BU of 8tco by Molmil
HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS2it1p2_F7K Fab heavy chain, ...
Authors:Goldsmith, J.G, McLellan, J.S.
Deposit date:2023-07-02
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:HCMV neutralization by broad antibody targeting
To Be Published
8TEA
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BU of 8tea by Molmil
HCMV Pentamer in complex with CS2pt1p2_A10L Fab and CS3pt1p4_C1L Fab
Descriptor: CS2pt1p2_A10L Fab heavy chain, CS2pt1p2_A10L Fab light chain, CS3pt1p4_C1L Fab heavy chain, ...
Authors:Goldsmith, J.G, McLellan, J.S.
Deposit date:2023-07-05
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:HCMV neutralization by broad antibody targeting
To Be Published
5WB0
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BU of 5wb0 by Molmil
Crystal structure of human metapneumovirus fusion glycoprotein stabilized in the prefusion state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2017-06-27
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein.
Nat Commun, 8, 2017
5VZR
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BU of 5vzr by Molmil
Crystal Structure of MERS-CoV neutralizing antibody G4 Fab
Descriptor: G4 antibody heavy chain, G4 antibody light chain, GLYCEROL
Authors:Wang, N, Wrapp, D, McLellan, J.S.
Deposit date:2017-05-29
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W23
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BU of 5w23 by Molmil
Crystal Structure of RSV F in complex with 5C4 Fab
Descriptor: 5C4 Fab heavy chain, 5C4 Fab light chain, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2017-06-05
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.
Nat Commun, 8, 2017
5VYH
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BU of 5vyh by Molmil
Crystal Structure of MERS-CoV S1 N-terminal Domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ...
Authors:Wang, N, Wrapp, D, Pallesen, J, Ward, A.B, McLellan, J.S.
Deposit date:2017-05-25
Release date:2017-08-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6EAG
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BU of 6eag by Molmil
CRYSTAL STRUCTURE OF FUSION INHIBITOR JNJ-2408068 IN COMPLEX WITH HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol, D(-)-TARTARIC ACID, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.302 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
6EAN
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BU of 6ean by Molmil
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT F488I STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
6U7K
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BU of 6u7k by Molmil
Prefusion structure of PEDV spike
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2019-09-03
Release date:2019-09-18
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation.
J.Virol., 93, 2019
6EAH
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BU of 6eah by Molmil
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT K394R-S398L STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
6EAL
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BU of 6eal by Molmil
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT D486N STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, D(-)-TARTARIC ACID, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published

222415

건을2024-07-10부터공개중

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