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PDB: 12 results
5J45
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BU of 5j45 by Molmil
Crystal structure of Shrub, fly ortholog of SNF7/CHMP4B
Descriptor: GH13992p
Authors:McMillan, B.J, Blacklow, S.C.
Deposit date:2016-03-31
Release date:2016-07-20
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.758 Å)
Cite:Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein.
Cell Rep, 16, 2016
4TSE
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BU of 4tse by Molmil
Crystal Structure of the Mib Repeat Domain of Mind bomb 1
Descriptor: E3 ubiquitin-protein ligase MIB1
Authors:McMillan, B.J, Blacklow, S.C.
Deposit date:2014-06-18
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.057 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
7M05
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BU of 7m05 by Molmil
CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988
Descriptor: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide, Methylosome protein 50, Protein arginine N-methyltransferase 5
Authors:McMillan, B.J, McKinney, D.C, Timm, D.E.
Deposit date:2021-03-10
Release date:2021-03-17
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J.Med.Chem., 64, 2021
4XI7
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BU of 4xi7 by Molmil
Crystal structure of the MZM-REP domains of Mind bomb 1 in complex with Jagged1 N-box peptide
Descriptor: E3 ubiquitin-protein ligase MIB1, Jagged 1 N-box peptide, SULFATE ION, ...
Authors:McMillan, B.J, Blacklow, S.C.
Deposit date:2015-01-06
Release date:2015-03-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.051 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4XIB
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BU of 4xib by Molmil
Crystal structure of the MZM-REP domains of Mind bomb 1 in complex with fly Delta N-box peptide
Descriptor: Delta N-box peptide, E3 ubiquitin-protein ligase MIB1, SULFATE ION, ...
Authors:McMillan, B.J, Blacklow, S.C.
Deposit date:2015-01-06
Release date:2015-03-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.147 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4XI6
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BU of 4xi6 by Molmil
Crystal structure of the MZM-REP domains of Mind bomb 1
Descriptor: E3 ubiquitin-protein ligase MIB1, SULFATE ION, ZINC ION
Authors:McMillan, B.J, Blacklow, S.C.
Deposit date:2015-01-06
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
5VNY
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BU of 5vny by Molmil
Crystal structure of DM14-3 domain of Lgd
Descriptor: Lethal (2) giant discs 1, isoform B
Authors:McMillan, B.J, Blacklow, S.C.
Deposit date:2017-05-01
Release date:2017-06-14
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:Structural Basis for Regulation of ESCRT-III Complexes by Lgd.
Cell Rep, 19, 2017
5VO5
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BU of 5vo5 by Molmil
Crystal structure of Lgd-Shrub complex, single chain fusion
Descriptor: Coiled-coil and C2 domain-containing protein 1-like,GH13992p
Authors:McMillan, B.J, Seegar, T.C.M, Blacklow, S.C.
Deposit date:2017-05-02
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Structural Basis for Regulation of ESCRT-III Complexes by Lgd.
Cell Rep, 19, 2017
6V0N
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BU of 6v0n by Molmil
PRMT5 bound to PBM peptide from Riok1
Descriptor: Methylosome protein 50, Protein arginine N-methyltransferase 5, Riok1 PBM peptide, ...
Authors:McMIllan, B.J, Raymond, D.D.
Deposit date:2019-11-19
Release date:2020-08-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mol.Cell, 81, 2021
6V0O
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BU of 6v0o by Molmil
PRMT5 bound to the PBM peptide from pICln
Descriptor: ACETYL GROUP, Methylosome protein 50, PBM peptide, ...
Authors:McMillan, B.J, Raymond, D.D.
Deposit date:2019-11-19
Release date:2020-08-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mol.Cell, 81, 2021
6V0P
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BU of 6v0p by Molmil
PRMT5 complex bound to covalent PBM inhibitor BRD6711
Descriptor: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide, CHLORIDE ION, GLYCEROL, ...
Authors:McMillan, B.J, McKinney, D.C.
Deposit date:2019-11-19
Release date:2020-11-25
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J.Med.Chem., 64, 2021
5TCX
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BU of 5tcx by Molmil
Crystal structure of human tetraspanin CD81
Descriptor: CD81 antigen, CHOLESTEROL
Authors:Zimmerman, B, McMillan, B.J, Seegar, T.C.M, Kruse, A.C, Blacklow, S.C.
Deposit date:2016-09-16
Release date:2016-11-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.955 Å)
Cite:Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.
Cell, 167, 2016

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