6U9V
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6U9W
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5SVR
| Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist A-317491 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid, MAGNESIUM ION, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-10-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVK
| Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, open state | Descriptor: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-06 | Release date: | 2016-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.773 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVT
| Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion channel through the extracellular fenestrations | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-09-28 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.794 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVP
| Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state | Descriptor: | 1,2-ETHANEDIOL, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.298 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVL
| Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed (desensitized) state | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-06 | Release date: | 2016-10-05 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVS
| Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.025 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVJ
| Crystal structure of the ATP-gated human P2X3 ion channel in the closed, apo state | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-06 | Release date: | 2016-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.984 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVQ
| Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-07 | Release date: | 2016-10-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVM
| Crystal structure of the ATP-gated human P2X3 ion channel bound to agonist 2-methylthio-ATP in the desensitized state | Descriptor: | 1,2-ETHANEDIOL, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2016-08-06 | Release date: | 2016-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.093 Å) | Cite: | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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9C2A
| Cryo-EM structure of the human P2X1 receptor in the apo closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Oken, A.C, Lisi, N.E, Ditter, I.A, Shi, H, Mansoor, S.E. | Deposit date: | 2024-05-30 | Release date: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding. Nat Commun, 15, 2024
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9C2B
| Cryo-EM structure of the human P2X1 receptor in the ATP-bound desensitized state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Oken, A.C, Lisi, N.E, Ditter, I.A, Shi, H, Mansoor, S.E. | Deposit date: | 2024-05-30 | Release date: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.42 Å) | Cite: | Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding. Nat Commun, 15, 2024
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9C2C
| Cryo-EM structure of the human P2X1 receptor in the NF449-bound inhibited state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4'',4'''-{carbonylbis[azanediylbenzene-5,1,3-triylbis(carbonylazanediyl)]}tetra(benzene-1,3-disulfonic acid), P2X purinoceptor 1 | Authors: | Oken, A.C, Lisi, N.E, Ditter, I.A, Shi, H, Mansoor, S.E. | Deposit date: | 2024-05-30 | Release date: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding. Nat Commun, 15, 2024
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8TR5
| Cryo-EM structure of the rat P2X7 receptor in the apo closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8TRJ
| Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8V4S
| Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | Deposit date: | 2023-11-29 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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8TRK
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist methyl blue | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4''-[methanetriyltris(4,1-phenyleneazanediyl)]tri(benzene-1-sulfonic acid), GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TR8
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.21 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TRB
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.36 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TRA
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TR7
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A839977 | Descriptor: | (1P)-1-(2,3-dichlorophenyl)-N-({2-[(pyridin-2-yl)oxy]phenyl}methyl)-1H-tetrazol-5-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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8TR6
| Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A438079 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{[(5R)-5-(2,3-dichlorophenyl)tetrazolidin-1-yl]methyl}pyridine, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | Deposit date: | 2023-08-09 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.18 Å) | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024
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