2JO4
 
 | | Tetrameric structure of KIA7 peptide | | 分子名称: | KIA7 | | 著者 | Lopez de la Osa, J, Gonzalez, C, Laurents, D.V, Chakrabartty, A, Bateman, D.A. | | 登録日 | 2007-02-21 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Getting specificity from simplicity in putative proteins from the prebiotic earth.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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1H1W
 | | High resolution crystal structure of the human PDK1 catalytic domain | | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | | 著者 | Biondi, R.M, Komander, D, Thomas, C.C, Lizcano, J.M, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | | 登録日 | 2002-07-23 | | 公開日 | 2003-07-17 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | High Resolution Crystal Structure of the Human Pdk1 Catalytic Domain Defines the Regulatory Phosphopeptide Docking Site
Embo J., 21, 2003
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2N85
 | | NMR structure of OtTx1a - AMP in DPC micelles | | 分子名称: | Spiderine-1a | | 著者 | Nadezhdin, K, Romanovskaya, D, Sachkova, M, Vassilevski, A, Grishin, E, Kovalchuk, S, Arseniev, A. | | 登録日 | 2015-10-05 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Modular toxin from the lynx spider Oxyopes takobius: Structure of spiderine domains in solution and membrane-mimicking environment.
Protein Sci., 26, 2017
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6PQ3
 | | Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Dharmaiah, S, Chan, A.H, Tran, T.H, Simanshu, D.K. | | 登録日 | 2019-07-08 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
J.Biol.Chem., 295, 2020
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3R0N
 | | Crystal Structure of the Immunoglobulin variable domain of Nectin-2 | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Poliovirus receptor-related protein 2 | | 著者 | Ramagopal, U.A, Samanta, D, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | | 登録日 | 2011-03-08 | | 公開日 | 2011-04-27 | | 最終更新日 | 2012-11-07 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2F1F
 | | Crystal structure of the regulatory subunit of acetohydroxyacid synthase isozyme III from E. coli | | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Acetolactate synthase isozyme III small subunit, MAGNESIUM ION, ... | | 著者 | Kaplun, A, Vyazmensky, M, Barak, Z, Chipman, D.M, Shaanan, B. | | 登録日 | 2005-11-14 | | 公開日 | 2006-01-24 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure of the Regulatory Subunit of Acetohydroxyacid Synthase Isozyme III from Escherichia coli.
J.Mol.Biol., 357, 2006
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1PO2
 | | POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION | | 分子名称: | (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | | 著者 | Hiremath, C.N, Filman, D.J, Grant, R.A, Hogle, J.M. | | 登録日 | 1997-01-08 | | 公開日 | 1997-12-03 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Ligand-induced conformational changes in poliovirus-antiviral drug complexes.
Acta Crystallogr.,Sect.D, 53, 1997
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6HEJ
 | | Structure of human USP28 | | 分子名称: | SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28 | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
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1JU6
 | | Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, PHOSPHATE ION, ... | | 著者 | Sayre, P.H, Finer-Moore, J.S, Fritz, T.A, Biermann, D, Gates, S.B, MacKellar, W.C, Patel, V.F, Stroud, R.M. | | 登録日 | 2001-08-23 | | 公開日 | 2001-09-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
J.Mol.Biol., 313, 2001
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3RQ3
 | | Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form | | 分子名称: | CHLORIDE ION, T cell immunoreceptor with Ig and ITIM domains | | 著者 | Ramagopal, U.A, Rubinstein, R, Guo, H, Samanta, D, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | | 登録日 | 2011-04-27 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form
To be published
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3MJX
 | | Crystal structure of myosin-2 motor domain in complex with ADP-Metavanadate and blebbistatin | | 分子名称: | (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, ADP METAVANADATE, MAGNESIUM ION, ... | | 著者 | Fedorov, R, Baruch, P, Bauer, S, Manstein, D.J. | | 登録日 | 2010-04-13 | | 公開日 | 2011-04-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The mechanism of pentabromopseudilin inhibition of myosin motor activity.
Nat.Struct.Mol.Biol., 16, 2009
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1HA5
 | | Structural features of a zinc-binding site in the superantigen streptococcal pyrogenic exotoxin A (SpeA1): implications for MHC class II recognition. | | 分子名称: | STREPTOCOCCAL PYOGENIC EXOTOXIN A1, ZINC ION | | 著者 | Baker, M.D, Gutman, D.M, Papageorgiou, A.C, Collins, C.M, Acharya, K.R. | | 登録日 | 2001-03-28 | | 公開日 | 2002-04-03 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Structural Features of a Zinc Binding Site in the Superantigen Strepococcal Pyrogenic Exotoxin a (Spea1): Implications for Mhc Class II Recognition.
Protein Sci., 10, 2001
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7PEQ
 | | Model of the outer rings of the human nuclear pore complex | | 分子名称: | Nuclear pore complex protein Nup107, Nuclear pore complex protein Nup133, Nuclear pore complex protein Nup160, ... | | 著者 | Schuller, A.P, Wojtynek, M, Mankus, D, Tatli, M, Kronenberg-Tenga, R, Regmi, S.G, Dasso, M, Weis, K, Medalia, O, Schwartz, T.U. | | 登録日 | 2021-08-11 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (35 Å) | | 主引用文献 | The cellular environment shapes the nuclear pore complex architecture.
Nature, 598, 2021
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4KVS
 | | Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant A134F) | | 分子名称: | Aldehyde decarbonylase, FE (III) ION, HEXANOIC ACID | | 著者 | Levy, C.W, Khara, B, Menon, N, Mansell, D, Das, D, Marsh, E.N.G, Leys, D, Scrutton, N.S. | | 登録日 | 2013-05-23 | | 公開日 | 2013-06-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase.
Chembiochem, 14, 2013
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4MF3
 | | Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist | | 分子名称: | (3S,4aS,6S,8aR)-6-[3-chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydroisoquinoline-3-carboxylic acid, Glutamate receptor ionotropic, kainate 1 | | 著者 | Martinez-Perez, J.A, Iyengar, S, Shannon, H.E, Bleakman, D, Alt, A, Clawson, D.K, Arnold, B.M, Bell, M.G, Bleisch, T.J, Castano, A.M, Del Prado, M, Dominguez, E, Escribano, A.M, Filla, S.A, Ho, K.H, Hudziak, K.J, Jones, C.K, Katofiasc, M.A, Mateo, A, Mathes, B.M, Mattiuz, E.L, Ogden, A.M.L, Phebus, L.A, Simmons, R.M.A, Stack, D.R, Stratford, R.E, Winter, M.A, Wu, Z, Ornstein, P.L. | | 登録日 | 2013-08-27 | | 公開日 | 2014-05-07 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.
Bioorg.Med.Chem.Lett., 23, 2013
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7NW2
 | | Crystal Structure of SARS-CoV-2 main protease in complex with LON-WEI-adc59df6-47 | | 分子名称: | 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Fearon, D, Douangamath, A, Aimon, A, Brandao-Neto, J, Dias, A, Dunnett, L, Gehrtz, P, Gorrie-Stone, T.J, Lukacik, P, Powell, A.J, Skyner, R, Strain-Damerell, C.M, Zaidman, D, London, N, Walsh, M.A, von Delft, F, Covid Moonshot Consortium | | 登録日 | 2021-03-16 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M pro inhibitor.
Cell Chem Biol, 28, 2021
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3PHU
 | | OTU Domain of Crimean Congo Hemorrhagic Fever Virus | | 分子名称: | GLYCEROL, RNA-directed RNA polymerase L | | 著者 | Akutsu, M, Ye, Y, Virdee, S, Komander, D. | | 登録日 | 2010-11-04 | | 公開日 | 2011-02-02 | | 最終更新日 | 2014-11-12 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2N86
 | | NMR structure of OtTx1a - ICK | | 分子名称: | Spiderine-1a | | 著者 | Nadezhdin, K, Romanovskaya, D, Sachkova, M, Vassilevski, A, Grishin, E, Kovalchuk, S, Arseniev, A. | | 登録日 | 2015-10-05 | | 公開日 | 2016-10-19 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Modular toxin from the lynx spider Oxyopes takobius: Structure of spiderine domains in solution and membrane-mimicking environment.
Protein Sci., 26, 2017
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6HEH
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6HEI
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4JIT
 | | Crystal Structure of E. coli XGPRT in complex with (S)-3-(Guanin-9-yl)pyrrolidin-N-ylacetylphosphonic acid | | 分子名称: | Xanthine phosphoribosyltransferase, {2-[(3S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pyrrolidin-1-yl]-2-oxoethyl}phosphonic acid | | 著者 | Keough, D.T, Hockova, D, Rejman, D, Spacek, P, Vrbkova, S, Krecmerova, M, Eng, W.S, Jans, H, West, N.P, Naesens, L.M.J, de Jersey, J, Guddat, L.W. | | 登録日 | 2013-03-07 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
J.Med.Chem., 56, 2013
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6HEL
 | | Structure of human USP25 | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 25 | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.941 Å) | | 主引用文献 | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
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2NT4
 | | Receiver domain from Myxococcus xanthus social motility protein FrzS (H92F mutant) | | 分子名称: | CHLORIDE ION, Response regulator homolog | | 著者 | Echols, N, Fraser, J, Weisfield, S, Merlie, J, Zusman, D, Alber, T. | | 登録日 | 2006-11-06 | | 公開日 | 2007-03-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | | 主引用文献 | An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS.
Mol.Microbiol., 65, 2007
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1JOC
 | | EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate | | 分子名称: | Early Endosomal Autoantigen 1, PHOSPHORIC ACID MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL) ESTER, ZINC ION | | 著者 | Dumas, J.J, Merithew, E, Rajamani, D, Hayes, S, Lawe, D, Corvera, S, Lambright, D.G. | | 登録日 | 2001-07-27 | | 公開日 | 2001-12-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Multivalent endosome targeting by homodimeric EEA1.
Mol.Cell, 8, 2001
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1Z1G
 | | Crystal structure of a lambda integrase tetramer bound to a Holliday junction | | 分子名称: | 25-MER, 29-MER, 5'-D(*AP*CP*AP*GP*GP*TP*CP*AP*CP*TP*AP*TP*CP*AP*GP*TP*CP*AP*AP*AP*AP*TP*AP*CP*C)-3', ... | | 著者 | Biswas, T, Aihara, H, Radman-Livaja, M, Filman, D, Landy, A, Ellenberger, T. | | 登録日 | 2005-03-03 | | 公開日 | 2005-06-28 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | | 主引用文献 | A structural basis for allosteric control of DNA recombination by lambda integrase.
Nature, 435, 2005
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