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PDB: 138 件
4WFG
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Human TRAAK K+ channel in a Tl+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, MacKinnon, R.
登録日2014-09-15
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFE
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BU of 4wfe by Molmil
Human TRAAK K+ channel in a K+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, MacKinnon, R.
登録日2014-09-15
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFF
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BU of 4wff by Molmil
Human TRAAK K+ channel in a K+ bound nonconductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, MacKinnon, R.
登録日2014-09-15
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
8GHG
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BU of 8ghg by Molmil
Cryo-EM structure of hSlo1 in digitonin, Ca2+-free and EDTA-free
分子名称: Calcium-activated potassium channel subunit alpha-1
著者Tao, X, Zhao, C, MacKinnon, R.
登録日2023-03-10
公開日2023-05-10
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Membrane protein isolation and structure determination in cell-derived membrane vesicles.
Proc.Natl.Acad.Sci.USA, 120, 2023
8GH9
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BU of 8gh9 by Molmil
Cryo-EM structure of hSlo1 in total membrane vesicles
分子名称: Calcium-activated potassium channel subunit alpha-1
著者Tao, X, Zhao, C, MacKinnon, R.
登録日2023-03-09
公開日2023-05-10
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Membrane protein isolation and structure determination in cell-derived membrane vesicles.
Proc.Natl.Acad.Sci.USA, 120, 2023
6XIS
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BU of 6xis by Molmil
Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in apo form
分子名称: G protein-activated inward rectifier potassium channel 2
著者Niu, Y, Tao, X, MacKinnon, R.
登録日2020-06-21
公開日2020-10-07
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
6XIT
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BU of 6xit by Molmil
Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with PIP2
分子名称: G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Niu, Y, Tao, X, MacKinnon, R.
登録日2020-06-21
公開日2020-10-07
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
7N0L
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BU of 7n0l by Molmil
Cryo-EM structure of TACAN in the H196A H197A mutant form (TMEM120A)
分子名称: COENZYME A, Ion channel TACAN
著者Niu, Y, Tao, X, MacKinnon, R.
登録日2021-05-25
公開日2021-09-15
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Analysis of the mechanosensor channel functionality of TACAN.
Elife, 10, 2021
7N0K
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BU of 7n0k by Molmil
Cryo-EM structure of TACAN in the apo form (TMEM120A)
分子名称: Ion channel TACAN
著者Niu, Y, Tao, X, MacKinnon, R.
登録日2021-05-25
公開日2021-09-15
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Analysis of the mechanosensor channel functionality of TACAN.
Elife, 10, 2021
3MT5
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BU of 3mt5 by Molmil
Crystal Structure of the Human BK Gating Apparatus
分子名称: CALCIUM ION, Potassium large conductance calcium-activated channel, subfamily M, ...
著者Yuan, P, MacKinnon, R.
登録日2010-04-30
公開日2010-06-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.
Science, 329, 2010
4I9W
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BU of 4i9w by Molmil
Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
分子名称: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, Mackinnon, R.
登録日2012-12-05
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HPF
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BU of 4hpf by Molmil
Structure of the human SLO3 gating ring
分子名称: Potassium channel subfamily U member 1
著者Leonetti, M.D, Yuan, P, MacKinnon, R.
登録日2012-10-23
公開日2012-11-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Proc.Natl.Acad.Sci.USA, 109, 2012
6CNO
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BU of 6cno by Molmil
Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II
分子名称: CALCIUM ION, Calmodulin-1, Intermediate conductance calcium-activated potassium channel protein 4
著者Lee, C.H, MacKinnon, R.
登録日2018-03-08
公開日2018-05-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6CNM
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BU of 6cnm by Molmil
Cryo-EM structure of the human SK4/calmodulin channel complex
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ...
著者Lee, C.H, MacKinnon, R.
登録日2018-03-08
公開日2018-05-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
5A6G
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BU of 5a6g by Molmil
Cryo-EM structure of the Slo2.2 Na-activated K channel
分子名称: PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, S1-S4 DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1
著者Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R.
登録日2015-06-25
公開日2015-10-14
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
5A6F
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BU of 5a6f by Molmil
Cryo-EM structure of the Slo2.2 Na-activated K channel
分子名称: GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1
著者Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R.
登録日2015-06-25
公開日2015-10-14
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
2A79
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BU of 2a79 by Molmil
Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ...
著者Long, S.B, Campbell, E.B, MacKinnon, R.
登録日2005-07-05
公開日2005-07-12
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
Science, 309, 2005
5A6E
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BU of 5a6e by Molmil
Cryo-EM structure of the Slo2.2 Na-activated K channel
分子名称: GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, ...
著者Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R.
登録日2015-06-25
公開日2015-10-14
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
6B3R
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BU of 6b3r by Molmil
Structure of the mechanosensitive channel Piezo1
分子名称: Piezo-type mechanosensitive ion channel component 1, unknown fragment
著者Guo, Y.R, MacKinnon, R.
登録日2017-09-22
公開日2017-12-20
最終更新日2018-05-16
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure-based membrane dome mechanism for Piezo mechanosensitivity.
Elife, 6, 2017
4KFM
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BU of 4kfm by Molmil
Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits
分子名称: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Whorton, M.R, MacKinnon, R.
登録日2013-04-27
公開日2013-06-12
最終更新日2013-09-11
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献X-ray structure of the mammalian GIRK2-beta gamma G-protein complex.
Nature, 498, 2013
8SIK
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BU of 8sik by Molmil
KCNQ1 with voltage sensor in the up conformation
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
著者Mandala, V.S, MacKinnon, R.
登録日2023-04-16
公開日2023-05-31
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
8SIM
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BU of 8sim by Molmil
KCNQ1 with voltage sensor in the intermediate conformation
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
著者Mandala, V.S, MacKinnon, R.
登録日2023-04-16
公開日2023-05-31
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (6.2 Å)
主引用文献The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
8SIN
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BU of 8sin by Molmil
KCNQ1 with voltage sensor in the down conformation
分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
著者Mandala, V.S, MacKinnon, R.
登録日2023-04-16
公開日2023-05-31
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
6C3P
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BU of 6c3p by Molmil
Cryo-EM structure of human KATP bound to ATP and ADP in propeller form
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Lee, K.P.K, Chen, J, MacKinnon, R.
登録日2018-01-10
公開日2018-01-24
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献Molecular structure of human KATP in complex with ATP and ADP.
Elife, 6, 2017
6C3O
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BU of 6c3o by Molmil
Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Lee, K.P.K, Chen, J, MacKinnon, R.
登録日2018-01-10
公開日2018-01-31
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Molecular structure of human KATP in complex with ATP and ADP
Elife, 6, 2017

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