5BVF
 
 | | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase | | 分子名称: | 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-8-(2-{[(1S,3R)-3-hydroxycyclopentyl]amino}pyrimidin-4-yl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Ma, X, Steven, S. | | 登録日 | 2015-06-05 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
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8DEY
 | | Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709 | | 分子名称: | (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | | 著者 | Ma, X, Ornelas, E, Clifton, M.C. | | 登録日 | 2022-06-21 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Cell Chem Biol, 30, 2023
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5BVD
 | | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase | | 分子名称: | 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-7-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Ma, X, Steven, S. | | 登録日 | 2015-06-05 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
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5BVE
 | | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase | | 分子名称: | 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-8-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Ma, X, Steven, S. | | 登録日 | 2015-06-05 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
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4EUU
 | | Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172 | | 分子名称: | GLYCEROL, IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ... | | 著者 | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | 登録日 | 2012-04-25 | | 公開日 | 2012-05-23 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4EUT
 | | Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain | | 分子名称: | IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, SULFATE ION, ... | | 著者 | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | 登録日 | 2012-04-25 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3P9W
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6IZT
 | | Crystal structure of Haemophilus Influenzae BamA POTRA3-5 | | 分子名称: | Outer membrane protein assembly factor BamA | | 著者 | Ma, X, Wang, Q, Li, Y, Tan, P, Wu, H, Wang, P, Dong, X, Hong, L, Meng, G. | | 登録日 | 2018-12-20 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | How BamA recruits OMP substratesviapoly-POTRAs domain.
Faseb J., 33, 2019
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6IZS
 | | Crystal structure of Haemophilus influenzae BamA POTRA4 | | 分子名称: | Outer membrane protein assembly factor BamA | | 著者 | Ma, X, Wang, Q, Li, Y, Tan, P, Wu, H, Wang, P, Dong, X, Hong, L, Meng, G. | | 登録日 | 2018-12-20 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | How BamA recruits OMP substratesviapoly-POTRAs domain.
Faseb J., 33, 2019
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5EF9
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5EFA
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5EFC
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4K3J
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6J09
 | | Crystal structure of Haemophilus Influenzae BamA POTRA1-4 | | 分子名称: | Outer membrane protein assembly factor BamA | | 著者 | Ma, X, Wang, Q, Li, Y, Tan, P, Wu, H, Wang, P, Dong, X, Hong, L, Meng, G. | | 登録日 | 2018-12-21 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | How BamA recruits OMP substratesviapoly-POTRAs domain.
Faseb J., 33, 2019
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7U8F
 | | Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709 | | 分子名称: | (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA damage-binding protein 1, ... | | 著者 | Ma, X, Ornelas, E, Clifton, M.C. | | 登録日 | 2022-03-08 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Cell Chem Biol, 30, 2023
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7Y47
 | | Crystal structure of bifunctional miltiradiene synthase from selaginella moellendorffii that complexed with GGPP | | 分子名称: | Bifunctional diterpene synthase, chloroplastic, GERANYLGERANYL DIPHOSPHATE, ... | | 著者 | Ma, X, Tao, Y, Jiang, T. | | 登録日 | 2022-06-14 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase.
Plant Biotechnol J, 21, 2023
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5WL0
 | | Co-crystal structure of Influenza A H3N2 PB2 (241-741) bound to VX-787 | | 分子名称: | (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, Polymerase basic protein 2 | | 著者 | Ma, X, Shia, S. | | 登録日 | 2017-07-25 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.
Sci Rep, 7, 2017
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5Z55
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7XH2
 | | Dihydrofolate Reductase-like Protein SacH in safracin biosynthesis | | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Uncharacterized protein sfcH | | 著者 | Ma, X, Shao, N, Ma, M, Tang, G. | | 登録日 | 2022-04-07 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis.
Acta Pharm Sin B, 13, 2023
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7XH4
 | | Dihydrofolate Reductase-like Protein SacH in safracin biosynthesis complex with safracin A | | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Safracin A, Uncharacterized protein sfcH | | 著者 | Ma, X, Shao, N, Zhang, Y, Yang, D, Ma, M, Tang, G. | | 登録日 | 2022-04-07 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis.
Acta Pharm Sin B, 13, 2023
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7WSO
 | | Structure of a membrane protein G | | 分子名称: | B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, Immunoglobulin heavy constant gamma 1 | | 著者 | Ma, X, Zhu, Y, Chen, Y, Huang, Z. | | 登録日 | 2022-01-30 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Cryo-EM structures of two human B cell receptor isotypes.
Science, 377, 2022
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8J5Z
 | | The cryo-EM structure of the TwOSC1 tetramer | | 分子名称: | Terpene cyclase/mutase family member, octyl beta-D-glucopyranoside | | 著者 | Ma, X, Yuru, T, Yunfeng, L, Jiang, T. | | 登録日 | 2023-04-24 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (4.75 Å) | | 主引用文献 | Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC.
Angew.Chem.Int.Ed.Engl., 62, 2023
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7XT6
 | | Structure of a membrane protein M3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, ... | | 著者 | Ma, X, Zhu, Y, Chen, Y, Huang, Z. | | 登録日 | 2022-05-16 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Cryo-EM structures of two human B cell receptor isotypes.
Science, 377, 2022
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7WAT
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7WSP
 | | Structure of a membrane protein M | | 分子名称: | B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, Isoform 2 of Immunoglobulin heavy constant mu | | 著者 | Ma, X, Zhu, Y, Chen, Y, Huang, Z. | | 登録日 | 2022-01-30 | | 公開日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (4.09 Å) | | 主引用文献 | Structure of a membrane protein M
To Be Published
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