5BVF

Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase

Summary for 5BVF

• Entry DOI: 10.2210/pdb5bvf/pdb
• Related: 5BVD 5BVE
• Descriptor: Mitogen-activated protein kinase 1, 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-8-(2-{[(1S,3R)-3-hydroxycyclopentyl]amino}pyrimidin-4-yl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton, spindle : P28482
• Total number of polymer chains: 1
• Total formula weight: 42429.92

Authors

Ma, X.,Steven, S. (deposition date: 2015-06-05, release date: 2015-09-09, Last modification date: 2023-09-27)

• Primary citation: Bagdanoff, J.T.,Jain, R.,Han, W.,Zhu, S.,Madiera, A.M.,Lee, P.S.,Ma, X.,Poon, D.; Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.; Bioorg.Med.Chem.Lett., 25:3788-3792, 2015; PubMed: 26259804; DOI: 10.1016/j.bmcl.2015.07.091

Experimental method

X-RAY DIFFRACTION (1.9 Å)