5OCJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ocj by Molmil](/molmil-images/mine/5ocj) | Crystal structure of Ag85C bound to cyclophostin 8beta inhibitor | Descriptor: | DIMETHYL SULFOXIDE, Diacylglycerol acyltransferase/mycolyltransferase Ag85C, methoxy-[(3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]pentadecyl]phosphinic acid | Authors: | Viljoen, A, Richard, M, Nguyen, P.C, Spilling, C.D, Canaan, S, Cavalier, J.F, Blaise, M, Kremer, L. | Deposit date: | 2017-07-03 | Release date: | 2018-01-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Cyclipostins and cyclophostin analogs inhibit the antigen 85C from J. Biol. Chem., 293, 2018
|
|
6SBQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sbq by Molmil](/molmil-images/mine/6sbq) | The crystal structure of PfA-M1 in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one | Descriptor: | DI(HYDROXYETHYL)ETHER, M1-family alanyl aminopeptidase, MALONATE ION, ... | Authors: | Salomon, E, Schmitt, M, Mouray, E, McEwen, A.G, Torchy, M, Poussin-Courmontagne, P, Alavi, S, Tarnus, C, Cavarelli, J, Florent, I, Albrecht, S. | Deposit date: | 2019-07-22 | Release date: | 2020-03-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation. Bioorg.Chem., 98, 2020
|
|
3MHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mhk by Molmil](/molmil-images/mine/3mhk) | Human tankyrase 2 - catalytic PARP domain in complex with 2-(2-pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol | Descriptor: | 2-pyridin-2-yl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, GLYCEROL, Tankyrase-2, ... | Authors: | Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kotenyova, T, Markova, N, Moche, M, Nordlund, P, Nyman, T, Persson, C, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-04-08 | Release date: | 2010-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Nat.Biotechnol., 30, 2012
|
|
5OG1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5og1 by Molmil](/molmil-images/mine/5og1) | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state | Descriptor: | Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Deville, C, Carroni, M, Franke, K.B, Topf, M, Bukau, B, Mogk, A, Saibil, H.R. | Deposit date: | 2017-07-11 | Release date: | 2017-08-16 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase. Sci Adv, 3, 2017
|
|
1ACD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1acd by Molmil](/molmil-images/mine/1acd) | V32D/F57H MUTANT OF MURINE ADIPOCYTE LIPID BINDING PROTEIN | Descriptor: | ADIPOCYTE LIPID BINDING PROTEIN | Authors: | Ory, J, Kane, C.D, Simpson, M, Banaszak, L.J, Bernlohr, D.A. | Deposit date: | 1997-02-06 | Release date: | 1997-06-16 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Biochemical and crystallographic analyses of a portal mutant of the adipocyte lipid-binding protein. J.Biol.Chem., 272, 1997
|
|
5GHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ghk by Molmil](/molmil-images/mine/5ghk) | Crystal Structure Analysis of Canine serum albumin | Descriptor: | Serum albumin | Authors: | Kihira, K, Yamada, K, Kureishi, M, Yokomaku, K, Shinohara, R, Akiyama, M, Komatsu, T. | Deposit date: | 2016-06-20 | Release date: | 2016-11-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Artificial Blood for Dogs Sci Rep, 6, 2016
|
|
3MNO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mno by Molmil](/molmil-images/mine/3mno) | Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, F608S) mutations at 1.55A | Descriptor: | DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ... | Authors: | Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A. | Deposit date: | 2010-04-22 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. J.Mol.Biol., 403, 2010
|
|
3MPR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mpr by Molmil](/molmil-images/mine/3mpr) | Crystal Structure of endonuclease/exonuclease/phosphatase family protein from Bacteroides thetaiotaomicron, Northeast Structural Genomics Consortium Target BtR318A | Descriptor: | ACETIC ACID, BROMIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kuzin, A, Su, M, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-04-27 | Release date: | 2010-05-26 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (1.899 Å) | Cite: | Northeast Structural Genomics Consortium Target BtR318A To be Published
|
|
3MRQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mrq by Molmil](/molmil-images/mine/3mrq) | Crystal Structure of MHC class I HLA-A2 molecule complexed with Melan-A MART1 decapeptide variant | Descriptor: | 10-meric peptide from Melanoma antigen recognized by T-cells 1, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Reiser, J.-B, Le Gorrec, M, Chouquet, A, Debeaupuis, E, Echasserieau, K, Saulquin, X, Bonneville, M, Housset, D. | Deposit date: | 2010-04-29 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of MHC class I HLA-A2 molecule complexed with Melan-A MART1 decapeptide variant To be Published
|
|
1J3F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1j3f by Molmil](/molmil-images/mine/1j3f) | Crystal Structure of an Artificial Metalloprotein:Cr(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin | Descriptor: | 'N,N'-BIS-(2-HYDROXY-3-METHYL-BENZYLIDENE)-BENZENE-1,2-DIAMINE', CHROMIUM ION, Myoglobin, ... | Authors: | Koshiyama, T, Kono, M, Ohashi, M, Ueno, T, Suzuki, A, Yamane, T, Watanabe, Y. | Deposit date: | 2003-01-24 | Release date: | 2004-05-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Coordinated Design of Cofactor and Active Site Structures in Development of New Protein Catalysts J.Am.Chem.Soc., 127, 2005
|
|
1ZOV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zov by Molmil](/molmil-images/mine/1zov) | Crystal Structure of Monomeric Sarcosine Oxidase from Bacillus sp. NS-129 | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Monomeric sarcosine oxidase | Authors: | Nagata, K, Sasaki, H, Ohtsuka, J, Hua, M, Okai, M, Kubota, K, Kamo, M, Ito, K, Ichikawa, T, Koyama, Y, Tanokura, M. | Deposit date: | 2005-05-14 | Release date: | 2006-05-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of monomeric sarcosine oxidase from Bacillus sp. NS-129 reveals multiple conformations at the active-site loop PROC.JPN.ACAD.,SER.B, 81, 2005
|
|
5LRS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lrs by Molmil](/molmil-images/mine/5lrs) | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with glutathione and a 30-bp operator PrfA-box motif | Descriptor: | DNA (30-MER), GLUTATHIONE, Listeriolysin positive regulatory factor A | Authors: | Hall, M, Grundstrom, C, Begum, A, Lindberg, M, Sauer, U.H, Almqvist, F, Johansson, J, Sauer-Eriksson, A.E. | Deposit date: | 2016-08-19 | Release date: | 2016-12-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
1A2D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1a2d by Molmil](/molmil-images/mine/1a2d) | PYRIDOXAMINE MODIFIED MURINE ADIPOCYTE LIPID BINDING PROTEIN | Descriptor: | ADIPOCYTE LIPID BINDING PROTEIN, CHLORIDE ION | Authors: | Ory, J, Mazhary, A, Kuang, H, Davies, R, Distefano, M, Banaszak, L. | Deposit date: | 1997-12-29 | Release date: | 1998-07-01 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural characterization of two synthetic catalysts based on adipocyte lipid-binding protein. Protein Eng., 11, 1998
|
|
5GSY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gsy by Molmil](/molmil-images/mine/5gsy) | Kinesin-8 motor, KIF19A, in the nucleotide-free state complexed with GDP-taxol microtubule | Descriptor: | Kinesin-like protein KIF19 | Authors: | Morikawa, M, Nitta, R, Yajima, H, Shigematsu, H, Kikkawa, M, Hirokawa, N. | Deposit date: | 2016-08-17 | Release date: | 2016-09-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A Elife, 5, 2016
|
|
1Y8L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y8l by Molmil](/molmil-images/mine/1y8l) | Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(trifluoro)ethyl] Thymidine (T*) | Descriptor: | 5'-D(*GP*CP*GP*TP*AP*(TFE)P*AP*CP*GP*C)-3'), MAGNESIUM ION, SPERMINE | Authors: | Egli, M, Minasov, G, Tereshko, V, Pallan, P.S, Teplova, M, Inamati, G.B, Lesnik, E.A, Owens, S.R, Ross, B.S, Prakash, T.P, Manoharan, M. | Deposit date: | 2004-12-13 | Release date: | 2005-06-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications. Biochemistry, 44, 2005
|
|
5GUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gup by Molmil](/molmil-images/mine/5gup) | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, Acyl carrier protein, ... | Authors: | Gu, J, Wu, M, Guo, R, Yang, M. | Deposit date: | 2016-08-30 | Release date: | 2017-03-29 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of Mammalian Respiratory Supercomplex I1III2IV1 Cell, 167, 2016
|
|
8WSV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wsv by Molmil](/molmil-images/mine/8wsv) | |
6HFT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hft by Molmil](/molmil-images/mine/6hft) | |
3MF2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mf2 by Molmil](/molmil-images/mine/3mf2) | Crystal structure of class II aaRS homologue (Bll0957) complexed with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Bll0957 protein, GLYCEROL, ... | Authors: | Weygand-Durasevic, I, Mocibob, M, Ivic, N, Bilokapic, S, Maier, T, Luic, M, Ban, N. | Deposit date: | 2010-04-01 | Release date: | 2010-07-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
8XB7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8xb7 by Molmil](/molmil-images/mine/8xb7) | |
8T7N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t7n by Molmil](/molmil-images/mine/8t7n) | Crystal structure of the R132H mutant of IDH1 bound to compound 1 | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | Deposit date: | 2023-06-20 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Mechanistic and Biostructural Studies of Mutant IDH1 To Be Published
|
|
8T7O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t7o by Molmil](/molmil-images/mine/8t7o) | Crystal structure of the R132H mutant of IDH1 bound to AG-120 | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ivosidenib | Authors: | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | Deposit date: | 2023-06-20 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.053 Å) | Cite: | Mechanistic and Biostructural Studies of Mutant IDH1 To Be Published
|
|
8T7D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t7d by Molmil](/molmil-images/mine/8t7d) | Crystal structure of wild type IDH1 bound to compound 1 | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide | Authors: | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | Deposit date: | 2023-06-20 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (3.444 Å) | Cite: | Mechanistic and Biostructural Studies of Mutant IDH1 To Be Published
|
|
5ICG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5icg by Molmil](/molmil-images/mine/5icg) | Crystal structure of apo (S)-norcoclaurine 6-O-methyltransferase | Descriptor: | (S)-norcoclaurine 6-O-methyltransferase, POTASSIUM ION | Authors: | Robin, A.Y, Graindorge, M, Giustini, C, Dumas, R, Matringe, M. | Deposit date: | 2016-02-23 | Release date: | 2016-06-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of norcoclaurine-6-O-methyltransferase, a key rate-limiting step in the synthesis of benzylisoquinoline alkaloids. Plant J., 87, 2016
|
|
1IX4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ix4 by Molmil](/molmil-images/mine/1ix4) | Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Carbon Monoxide | Descriptor: | CARBON MONOXIDE, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | Deposit date: | 2002-06-10 | Release date: | 2003-09-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1. Biochemistry, 42, 2003
|
|