3MHK

Human tankyrase 2 - catalytic PARP domain in complex with 2-(2-pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol

Summary for 3MHK

• Entry DOI: 10.2210/pdb3mhk/pdb
• Related: 3KR7 3KR8 3MHJ
• Descriptor: Tankyrase-2, ZINC ION, 2-pyridin-2-yl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, ... (5 entities in total)
• Functional Keywords: catalytic fragment, parp, structural genomics, structural genomics consortium, sgc, adp-ribosylation, ank repeat, chromosomal protein, glycosyltransferase, golgi apparatus, membrane, mrna transport, nad, nucleus, phosphorylation, protein transport, telomere, transferase, translocation, transport, wnt-signalling
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 1
• Total formula weight: 26070.86

Authors

Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kotenyova, T.,Markova, N.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-04-08, release date: 2010-05-05, Last modification date: 2023-11-01)

• Primary citation: Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J.; Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors; Nat.Biotechnol., 30:283-288, 2012; PubMed: 22343925; DOI: 10.1038/nbt.2121

Experimental method

X-RAY DIFFRACTION (2.3 Å)