3MHK
Human tankyrase 2 - catalytic PARP domain in complex with 2-(2-pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tankyrase-2 | polymer | 223 | 25483.9 | 1 | UniProt (Q9H2K2) Pfam (PF00644) | Homo sapiens (human) | TANK2, Tankyrase II, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase-like protein, Tankyrase-related protein, Poly [ADP-ribose] polymerase 5B |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 2-pyridin-2-yl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol | non-polymer | 245.3 | 1 | Chemie (P4L) | |||
| 4 | D, E, F (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | G (A) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A: 952 - 1166 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Met 951 | - | initiating methionine |
| Ala 1167 | - | expression tag |
| His 1168 | - | expression tag |
| His 1169 | - | expression tag |
| His 1170 | - | expression tag |
| His 1171 | - | expression tag |
| His 1172 | - | expression tag |
| His 1173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25483.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 587.0 | |
| All* | Total formula weight | 26070.9 |
