Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1

This is a large structure.

Summary for 5GUP

EMDB information9539
DescriptorCytochrome c oxidase subunit 6C, NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial, ... (81 entities in total)
Functional Keywordscryo-em, mammalian, respiratory, supercomplex, electron transport
Biological sourceSus scrofa (Pig)
Cellular locationMitochondrion inner membrane  F1S031 F1RWL7 F1STY1 F1SLR1 Q1HBG9 F1S3W0 F1RNZ1 F1RNZ1
Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side  F1SQP4 F1RGE3 F1SRG2
Mitochondrion matrix  F1SIS9
Mitochondrion inner membrane; Multi-pass membrane protein O79875 Q9TDR1 O79874
Mitochondrion membrane ; Multi- pass membrane protein  O79880 P56632 O79882 O79881
Total number of polymer chains80
Total molecular weight1818749.11
Gu, J.,Wu, M.,Guo, R.,Yang, M. (deposition date: 2016-08-30, release date: 2017-03-29)
Primary citation
Wu, M.,Gu, J.,Guo, R.,Huang, Y.,Yang, M.
Structure of Mammalian Respiratory Supercomplex I1III2IV1
Cell, 167:1598-1609.e10, 2016
PubMed: 27912063 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2016.11.012
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers252.6%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 5gup
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Molmil generated image of 5gup
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Molmil generated image of 5gup
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