5GUP

Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0005739	cellular_component	mitochondrion
0	0005743	cellular_component	mitochondrial inner membrane
0	0005750	cellular_component	mitochondrial respiratory chain complex III
0	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
0	0016020	cellular_component	membrane
0	0070469	cellular_component	respirasome
1	0005739	cellular_component	mitochondrion
1	0005743	cellular_component	mitochondrial inner membrane
1	0005750	cellular_component	mitochondrial respiratory chain complex III
1	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
1	0009060	biological_process	aerobic respiration
1	0016020	cellular_component	membrane
1	0070469	cellular_component	respirasome
2	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
2	0016020	cellular_component	membrane
2	0051537	molecular_function	2 iron, 2 sulfur cluster binding
3	0005739	cellular_component	mitochondrion
3	0005743	cellular_component	mitochondrial inner membrane
3	0005750	cellular_component	mitochondrial respiratory chain complex III
3	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
3	0016020	cellular_component	membrane
4	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
4	0016020	cellular_component	membrane
4	0051537	molecular_function	2 iron, 2 sulfur cluster binding
5	0005739	cellular_component	mitochondrion
5	0046872	molecular_function	metal ion binding
6	0004222	molecular_function	metalloendopeptidase activity
6	0006508	biological_process	proteolysis
6	0046872	molecular_function	metal ion binding
7	0005739	cellular_component	mitochondrion
7	0005743	cellular_component	mitochondrial inner membrane
7	0005750	cellular_component	mitochondrial respiratory chain complex III
7	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
7	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
7	0009055	molecular_function	electron transfer activity
7	0016020	cellular_component	membrane
7	0016491	molecular_function	oxidoreductase activity
7	0022904	biological_process	respiratory electron transport chain
7	0045275	cellular_component	respiratory chain complex III
7	0046872	molecular_function	metal ion binding
7	0070469	cellular_component	respirasome
7	1902600	biological_process	proton transmembrane transport
8	0009055	molecular_function	electron transfer activity
8	0020037	molecular_function	heme binding
9	0005750	cellular_component	mitochondrial respiratory chain complex III
9	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Aa	0005739	cellular_component	mitochondrion
Aa	0005743	cellular_component	mitochondrial inner membrane
Aa	0005750	cellular_component	mitochondrial respiratory chain complex III
Aa	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Aa	0016020	cellular_component	membrane
Aa	0021539	biological_process	subthalamus development
Aa	0021548	biological_process	pons development
Aa	0021680	biological_process	cerebellar Purkinje cell layer development
Aa	0021766	biological_process	hippocampus development
Aa	0021794	biological_process	thalamus development
Aa	0021854	biological_process	hypothalamus development
Aa	0021860	biological_process	pyramidal neuron development
Aa	0030901	biological_process	midbrain development
Aa	0070469	cellular_component	respirasome
Ab	0005739	cellular_component	mitochondrion
Ab	0005743	cellular_component	mitochondrial inner membrane
Ab	0005750	cellular_component	mitochondrial respiratory chain complex III
Ab	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Ab	0016020	cellular_component	membrane
Ab	0070469	cellular_component	respirasome
Ac	0005739	cellular_component	mitochondrion
Ac	0005743	cellular_component	mitochondrial inner membrane
Ac	0005750	cellular_component	mitochondrial respiratory chain complex III
Ac	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Ac	0009060	biological_process	aerobic respiration
Ac	0016020	cellular_component	membrane
Ac	0070469	cellular_component	respirasome
Ad	0005739	cellular_component	mitochondrion
Ad	0005743	cellular_component	mitochondrial inner membrane
Ad	0005750	cellular_component	mitochondrial respiratory chain complex III
Ad	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Ad	0016020	cellular_component	membrane
Ae	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Af	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Ag	0005751	cellular_component	mitochondrial respiratory chain complex IV
Ag	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Ah	0005746	cellular_component	mitochondrial respirasome
Ah	0005751	cellular_component	mitochondrial respiratory chain complex IV
Ah	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Ai	0005746	cellular_component	mitochondrial respirasome
Ai	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Aj	0005751	cellular_component	mitochondrial respiratory chain complex IV
Aj	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Ak	0004129	molecular_function	cytochrome-c oxidase activity
Ak	0009060	biological_process	aerobic respiration
Ak	0016020	cellular_component	membrane
Ak	0020037	molecular_function	heme binding
Ak	0045277	cellular_component	respiratory chain complex IV
Al	0004129	molecular_function	cytochrome-c oxidase activity
Al	0005507	molecular_function	copper ion binding
Al	0016020	cellular_component	membrane
Al	0016491	molecular_function	oxidoreductase activity
Al	0022900	biological_process	electron transport chain
Am	0004129	molecular_function	cytochrome-c oxidase activity
Am	0009055	molecular_function	electron transfer activity
Am	0016020	cellular_component	membrane
Am	0019646	biological_process	aerobic electron transport chain
Am	0022904	biological_process	respiratory electron transport chain
An	0005751	cellular_component	mitochondrial respiratory chain complex IV
An	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Ao	0005743	cellular_component	mitochondrial inner membrane
Ao	0005751	cellular_component	mitochondrial respiratory chain complex IV
Ao	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Ap	0005740	cellular_component	mitochondrial envelope
Ap	0005751	cellular_component	mitochondrial respiratory chain complex IV
Ap	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Aq	0005743	cellular_component	mitochondrial inner membrane
Aq	0005751	cellular_component	mitochondrial respiratory chain complex IV
Ar	0005739	cellular_component	mitochondrion
Ar	0045277	cellular_component	respiratory chain complex IV
B	0003954	molecular_function	NADH dehydrogenase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005747	cellular_component	mitochondrial respiratory chain complex I
B	0005829	cellular_component	cytosol
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0010181	molecular_function	FMN binding
B	0016020	cellular_component	membrane
B	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
B	0045271	cellular_component	respiratory chain complex I
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0055085	biological_process	transmembrane transport
B	0070469	cellular_component	respirasome
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0048038	molecular_function	quinone binding
C	0051287	molecular_function	NAD binding
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
E	0016491	molecular_function	oxidoreductase activity
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005747	cellular_component	mitochondrial respiratory chain complex I
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0016020	cellular_component	membrane
F	0070469	cellular_component	respirasome
G	0003954	molecular_function	NADH dehydrogenase activity
G	0005743	cellular_component	mitochondrial inner membrane
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0045333	biological_process	cellular respiration
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0055085	biological_process	transmembrane transport
H	0016020	cellular_component	membrane
H	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
H	0051539	molecular_function	4 iron, 4 sulfur cluster binding
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0048038	molecular_function	quinone binding
I	0051536	molecular_function	iron-sulfur cluster binding
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005747	cellular_component	mitochondrial respiratory chain complex I
J	0016020	cellular_component	membrane
J	0022900	biological_process	electron transport chain
J	0070469	cellular_component	respirasome
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005747	cellular_component	mitochondrial respiratory chain complex I
K	0006979	biological_process	response to oxidative stress
K	0016020	cellular_component	membrane
K	0032981	biological_process	mitochondrial respiratory chain complex I assembly
K	0070469	cellular_component	respirasome
M	0005743	cellular_component	mitochondrial inner membrane
M	0042773	biological_process	ATP synthesis coupled electron transport
N	0022904	biological_process	respiratory electron transport chain
O	0006633	biological_process	fatty acid biosynthetic process
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005747	cellular_component	mitochondrial respiratory chain complex I
P	0016020	cellular_component	membrane
P	0070469	cellular_component	respirasome
Q	0005747	cellular_component	mitochondrial respiratory chain complex I
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005747	cellular_component	mitochondrial respiratory chain complex I
R	0006979	biological_process	response to oxidative stress
R	0016020	cellular_component	membrane
R	0032981	biological_process	mitochondrial respiratory chain complex I assembly
R	0070469	cellular_component	respirasome
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005747	cellular_component	mitochondrial respiratory chain complex I
S	0016020	cellular_component	membrane
S	0031966	cellular_component	mitochondrial membrane
S	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S	0070469	cellular_component	respirasome
T	0005743	cellular_component	mitochondrial inner membrane
T	0005747	cellular_component	mitochondrial respiratory chain complex I
U	0005737	cellular_component	cytoplasm
U	0005739	cellular_component	mitochondrion
U	0005747	cellular_component	mitochondrial respiratory chain complex I
U	0005759	cellular_component	mitochondrial matrix
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0019136	molecular_function	deoxynucleoside kinase activity
U	0070469	cellular_component	respirasome
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005747	cellular_component	mitochondrial respiratory chain complex I
V	0016020	cellular_component	membrane
V	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005747	cellular_component	mitochondrial respiratory chain complex I
W	0016020	cellular_component	membrane
W	0070469	cellular_component	respirasome
X	0006633	biological_process	fatty acid biosynthetic process
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005747	cellular_component	mitochondrial respiratory chain complex I
Z	0005739	cellular_component	mitochondrion
Z	0022900	biological_process	electron transport chain
a	0005654	cellular_component	nucleoplasm
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005747	cellular_component	mitochondrial respiratory chain complex I
a	0016020	cellular_component	membrane
a	0032981	biological_process	mitochondrial respiratory chain complex I assembly
b	0005743	cellular_component	mitochondrial inner membrane
b	0005747	cellular_component	mitochondrial respiratory chain complex I
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
b	0016020	cellular_component	membrane
b	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005747	cellular_component	mitochondrial respiratory chain complex I
c	0005783	cellular_component	endoplasmic reticulum
c	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
c	0016020	cellular_component	membrane
c	0032981	biological_process	mitochondrial respiratory chain complex I assembly
c	0070469	cellular_component	respirasome
f	0005739	cellular_component	mitochondrion
f	0005747	cellular_component	mitochondrial respiratory chain complex I
g	0005743	cellular_component	mitochondrial inner membrane
g	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005747	cellular_component	mitochondrial respiratory chain complex I
h	0005758	cellular_component	mitochondrial intermembrane space
h	0016020	cellular_component	membrane
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0070469	cellular_component	respirasome
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005747	cellular_component	mitochondrial respiratory chain complex I
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0016020	cellular_component	membrane
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0055085	biological_process	transmembrane transport
i	0070469	cellular_component	respirasome
i	0072593	biological_process	reactive oxygen species metabolic process
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005747	cellular_component	mitochondrial respiratory chain complex I
j	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0016020	cellular_component	membrane
j	0055085	biological_process	transmembrane transport
j	0070469	cellular_component	respirasome
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0005747	cellular_component	mitochondrial respiratory chain complex I
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0016020	cellular_component	membrane
k	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
k	0042773	biological_process	ATP synthesis coupled electron transport
k	0055085	biological_process	transmembrane transport
k	0070469	cellular_component	respirasome
l	0003954	molecular_function	NADH dehydrogenase activity
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0005747	cellular_component	mitochondrial respiratory chain complex I
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0015990	biological_process	electron transport coupled proton transport
l	0016020	cellular_component	membrane
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0042773	biological_process	ATP synthesis coupled electron transport
l	0070469	cellular_component	respirasome
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0005747	cellular_component	mitochondrial respiratory chain complex I
m	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
m	0016020	cellular_component	membrane
m	0032981	biological_process	mitochondrial respiratory chain complex I assembly
m	0055085	biological_process	transmembrane transport
m	0070469	cellular_component	respirasome
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005747	cellular_component	mitochondrial respiratory chain complex I
n	0016607	cellular_component	nuclear speck
n	0032981	biological_process	mitochondrial respiratory chain complex I assembly
o	0005739	cellular_component	mitochondrion
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
q	0003954	molecular_function	NADH dehydrogenase activity
q	0005739	cellular_component	mitochondrion
q	0005743	cellular_component	mitochondrial inner membrane
q	0005747	cellular_component	mitochondrial respiratory chain complex I
q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
q	0009060	biological_process	aerobic respiration
q	0015990	biological_process	electron transport coupled proton transport
q	0016020	cellular_component	membrane
q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
q	0042773	biological_process	ATP synthesis coupled electron transport
q	0045271	cellular_component	respiratory chain complex I
q	0048039	molecular_function	ubiquinone binding
q	0070469	cellular_component	respirasome
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0005747	cellular_component	mitochondrial respiratory chain complex I
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0016020	cellular_component	membrane
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0055085	biological_process	transmembrane transport
r	0070469	cellular_component	respirasome
s	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
t	0005739	cellular_component	mitochondrion
u	0005739	cellular_component	mitochondrion
u	0046872	molecular_function	metal ion binding
v	0004222	molecular_function	metalloendopeptidase activity
v	0006508	biological_process	proteolysis
v	0046872	molecular_function	metal ion binding
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005750	cellular_component	mitochondrial respiratory chain complex III
w	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
w	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
w	0009055	molecular_function	electron transfer activity
w	0016020	cellular_component	membrane
w	0016491	molecular_function	oxidoreductase activity
w	0022904	biological_process	respiratory electron transport chain
w	0045275	cellular_component	respiratory chain complex III
w	0046872	molecular_function	metal ion binding
w	0070469	cellular_component	respirasome
w	1902600	biological_process	proton transmembrane transport
x	0009055	molecular_function	electron transfer activity
x	0020037	molecular_function	heme binding
y	0005750	cellular_component	mitochondrial respiratory chain complex III
y	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
z	0005739	cellular_component	mitochondrion
z	0005743	cellular_component	mitochondrial inner membrane
z	0005750	cellular_component	mitochondrial respiratory chain complex III
z	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
z	0016020	cellular_component	membrane
z	0021539	biological_process	subthalamus development
z	0021548	biological_process	pons development
z	0021680	biological_process	cerebellar Purkinje cell layer development
z	0021766	biological_process	hippocampus development
z	0021794	biological_process	thalamus development
z	0021854	biological_process	hypothalamus development
z	0021860	biological_process	pyramidal neuron development
z	0030901	biological_process	midbrain development
z	0070469	cellular_component	respirasome

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue SF4 B 501

Chain	Residue
B	ILE205
B	ILE424
B	CYS425
B	LEU427
B	PRO223
B	SER378
B	CYS379
B	GLY380
B	GLN381
B	CYS382
B	CYS385
B	THR423

---

site_id	AC2
Number of Residues	15
Details	binding site for residue FMN B 502

Chain	Residue
B	GLY87
B	ARG88
B	GLY89
B	LYS98
B	ASN116
B	ASP118
B	GLU119
B	GLY120
B	TYR204
B	GLY207
B	GLU208
B	GLU209
B	ALA243
B	ASN244
B	ALA426

---

site_id	AC3
Number of Residues	10
Details	binding site for residue FES E 301

Chain	Residue
E	CYS135
E	THR137
E	PRO139
E	CYS140
E	CYS176
E	LEU177
E	GLY178
E	ALA179
E	CYS180
E	MET185

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SF4 G 801

Chain	Residue
C	MET375
G	HIS124
G	CYS128
G	CYS131
G	GLN133
G	CYS137
G	GLN140

---

site_id	AC5
Number of Residues	10
Details	binding site for residue SF4 G 802

Chain	Residue
G	CYS176
G	ILE177
G	CYS179
G	THR180
G	CYS182
G	VAL206
G	CYS226
G	PRO227
G	ALA230
G	LEU231

---

site_id	AC6
Number of Residues	7
Details	binding site for residue FES G 803

Chain	Residue
G	CYS64
G	TYR65
G	ASN74
G	CYS75
G	ARG76
G	CYS78
G	CYS92

---

site_id	AC7
Number of Residues	9
Details	binding site for residue SF4 H 301

Chain	Residue
H	CYS113
H	ILE114
H	ALA115
H	CYS116
H	LYS117
H	CYS119
H	TYR145
H	CYS162
H	ALA166

---

site_id	AC8
Number of Residues	9
Details	binding site for residue SF4 H 302

Chain	Residue
H	HIS101
H	CYS123
H	CYS152
H	ILE153
H	TYR154
H	CYS155
H	GLY156
H	PHE157
H	CYS158

---

site_id	AC9
Number of Residues	11
Details	binding site for residue PLX H 303

Chain	Residue
C	ARG266
H	THR60
H	LEU61
H	TRP63
H	GLU65
H	LEU66
W	LEU43
r	MET184
r	PHE280
r	LEU288
r	PHE293

---

site_id	AD1
Number of Residues	8
Details	binding site for residue SF4 I 301

Chain	Residue
C	ARG138
C	HIS223
I	CYS91
I	CYS92
I	THR128
I	CYS156
I	CYS186
I	PRO187

---

site_id	AD2
Number of Residues	16
Details	binding site for residue NDP L 401

Chain	Residue
L	GLY60
L	THR62
L	GLY63
L	PHE64
L	LEU65
L	ARG85
L	LEU129
L	VAL130
L	GLY131
L	ARG132
L	PHE139
L	ILE167
L	LYS184
L	PRO203
L	ILE206
I	ARG216

---

site_id	AD3
Number of Residues	12
Details	binding site for residue ZMP Q 201

Chain	Residue
O	SER112
O	LEU113
Q	LYS29
Q	VAL32
Q	ARG33
Q	GLY59
Q	VAL63
Q	MET66
Q	PHE67
Q	ASN70
Q	ALA71
Q	LEU82

---

site_id	AD4
Number of Residues	9
Details	binding site for residue CDL V 201

Chain	Residue
V	TYR39
V	SER40
V	LEU43
V	LYS44
V	ARG58
V	TYR59
i	PHE113
i	LEU160
l	MET576

---

site_id	AD5
Number of Residues	7
Details	binding site for residue PLX V 202

Chain	Residue
V	TYR108
V	GLY109
o	PRO82
o	PRO84
o	SER87
o	ALA91
o	GLY94

---

site_id	AD6
Number of Residues	13
Details	binding site for residue PEE W 401

Chain	Residue
W	PHE140
W	ILE141
W	TYR143
W	THR144
m	GLY38
m	GLY42
m	LEU45
m	SER50
m	LEU54
m	PHE57
r	ILE73
r	SER80
r	ASN99

---

site_id	AD7
Number of Residues	12
Details	binding site for residue ZMP X 201

Chain	Residue
X	ASP111
X	SER112
X	LEU113
p	GLN13
p	VAL16
p	MET44
p	ARG47
p	PHE48
p	LYS52
p	ASN53
p	ALA67
p	PHE71

---

site_id	AD8
Number of Residues	12
Details	binding site for residue PEE i 501

Chain	Residue
C	GLN46
C	TYR53
i	THR285
i	LEU287
i	TYR291
l	SER567
q	LEU147
q	TYR148
q	PHE151
q	TYR152
q	ALA155
q	PEE501

---

site_id	AD9
Number of Residues	12
Details	binding site for residue PLX i 502

Chain	Residue
g	ARG10
g	PRO12
g	LEU13
g	LEU77
h	PRO2
i	THR132
i	TRP133
i	VAL336
i	MET339
i	SER345
i	LEU346
i	ASN347

---

site_id	AE1
Number of Residues	13
Details	binding site for residue CDL i 503

Chain	Residue
U	TYR341
g	CYS42
g	LEU45
g	VAL56
i	PRO238
i	VAL239
i	SER242
i	LEU243
i	MET245
q	TRP16
q	MET17
q	THR90
q	LEU94

---

site_id	AE2
Number of Residues	12
Details	binding site for residue PEE l 701

Chain	Residue
c	ASN115
c	ARG116
l	GLN170
l	LEU173
l	TYR174
l	GLY228
l	TYR529
l	MET533
l	HIS534
l	PRO537
l	ASN541
q	LEU405

---

site_id	AE3
Number of Residues	17
Details	binding site for residue CDL l 702

Chain	Residue
a	LEU68
a	ILE75
l	ILE19
l	SER22
l	ASN23
l	LYS28
l	ARG116
l	LYS119
l	TYR120
l	LEU123
l	MET150
q	THR357
q	LEU360
q	MET361
q	LEU364
q	PRO371
q	LEU445

---

site_id	AE4
Number of Residues	13
Details	binding site for residue PEE q 501

Chain	Residue
V	LEU124
V	GLU131
V	TRP133
i	ILE276
i	PEE501
l	THR566
q	TYR166
q	SER191
q	PHE194
q	ALA198
q	MET201
q	PHE261
q	LEU264

---

site_id	AE5
Number of Residues	10
Details	binding site for residue CDL s 201

Chain	Residue
g	LYS27
g	THR29
g	PRO31
g	ARG32
g	VAL34
g	TYR35
s	PHE169
s	TRP170
s	THR171
s	MET172

---

site_id	AE6
Number of Residues	9
Details	binding site for residue CDL u 501

Chain	Residue
u	PHE370
u	ARG470
u	TRP477
u	LEU478
u	ARG479
u	PEE502
w	ARG5
w	ILE19
w	HIS221

---

site_id	AE7
Number of Residues	8
Details	binding site for residue PEE u 502

Chain	Residue
2	PLX301
u	ARG470
u	SER473
u	PHE476
u	LEU478
u	CDL501
w	HIS221
w	ILE229

---

site_id	AE8
Number of Residues	11
Details	binding site for residue HEM w 401

Chain	Residue
w	ILE45
w	GLY48
w	LEU49
w	HIS83
w	ALA87
w	THR126
w	ALA127
w	GLY130
w	PRO134
w	HIS182
w	PRO186

---

site_id	AE9
Number of Residues	14
Details	binding site for residue HEM w 402

Chain	Residue
w	TRP31
w	GLY34
w	SER35
w	LEU37
w	HIS97
w	ARG100
w	SER106
w	TRP113
w	GLY116
w	LEU119
w	HIS196
w	LEU197
w	LEU200
w	ASN206

---

site_id	AF1
Number of Residues	10
Details	binding site for residue PEE w 403

Chain	Residue
w	TRP30
w	PHE95
w	VAL98
w	TYR103
w	TYR104
w	MET316
w	TRP326
w	LEU332
z	VAL49
z	CDL101

---

site_id	AF2
Number of Residues	16
Details	binding site for residue HEC x 401

Chain	Residue
x	CYS122
x	SER124
x	CYS125
x	HIS126
x	ASN190
x	ALA193
x	PRO195
x	TYR211
x	VAL212
x	LEU215
x	PHE238
x	ILE243
x	ALA244
x	MET245
x	ALA246
x	PRO248

---

site_id	AF3
Number of Residues	14
Details	binding site for residue CDL x 402

Chain	Residue
w	ASN32
w	LEU230
w	GLY231
w	PHE234
x	LEU301
x	PRO302
x	TYR305
x	LYS308
x	ARG309
y	ARG72
z	TYR30
z	ASN37
z	ARG41
z	CDL101

---

site_id	AF4
Number of Residues	12
Details	binding site for residue CDL z 101

Chain	Residue
w	SER28
w	SER29
w	TRP30
w	PHE33
w	TYR104
w	PEE403
x	CDL402
z	ARG41
z	THR42
z	CYS45
z	ILE46
z	VAL49

---

site_id	AF5
Number of Residues	10
Details	binding site for residue PLX 2 301

Chain	Residue
1	PHE21
1	ILE25
2	TYR115
2	VAL125
2	PEE302
u	PHE476
u	PEE502
w	ILE39
w	MET236
x	LYS311

---

site_id	AF6
Number of Residues	10
Details	binding site for residue PEE 2 302

Chain	Residue
2	ASN131
2	ALA132
2	PHE136
2	PLX301
w	MET236
w	LEU240
x	MET289
x	LYS292
x	MET293
x	MET297

---

site_id	AF7
Number of Residues	6
Details	binding site for residue FES 2 303

Chain	Residue
2	CYS217
2	CYS236
2	HIS239
2	SER241
2	TYR243
2	ALA254

---

site_id	AF8
Number of Residues	10
Details	binding site for residue PLX 4 301

Chain	Residue
4	TYR115
4	THR118
4	THR122
5	PHE476
5	CDL501
5	PEE502
7	LEU43
7	ILE229
8	MET307
Ac	PHE21

---

site_id	AF9
Number of Residues	9
Details	binding site for residue FES 4 302

Chain	Residue
4	CYS217
4	HIS219
4	LEU220
4	CYS222
4	CYS236
4	CYS238
4	HIS239
4	SER241
4	ALA254

---

site_id	AG1
Number of Residues	11
Details	binding site for residue CDL 5 501

Chain	Residue
4	PLX301
5	PHE370
5	ARG470
5	TRP477
5	LEU478
5	ARG479
5	PEE502
7	ILE4
7	ARG5
7	HIS221
Ad	TRP24

---

site_id	AG2
Number of Residues	11
Details	binding site for residue PEE 5 502

Chain	Residue
4	ALA126
4	VAL133
4	PLX301
5	SER473
5	PHE476
5	LEU478
5	CDL501
7	HIS221
7	ILE226
7	ILE229
Ad	ALA35

---

site_id	AG3
Number of Residues	9
Details	binding site for residue PEE 7 401

Chain	Residue
4	TYR127
4	ASN131
4	ALA132
4	PHE136
7	LEU43
7	LEU82
7	MET236
8	MET289
Ac	ASP37

---

site_id	AG4
Number of Residues	14
Details	binding site for residue PEE 7 402

Chain	Residue
7	TRP30
7	PHE95
7	GLY99
7	TYR103
7	TYR104
7	LEU120
7	MET316
7	GLN322
7	TRP326
7	LEU332
7	ILE333
Aa	ARG41
Aa	CYS45
Aa	CDL101

---

site_id	AG5
Number of Residues	15
Details	binding site for residue HEM 7 403

Chain	Residue
7	GLN44
7	GLY48
7	LEU49
7	LEU51
7	TYR55
7	ARG80
7	HIS83
7	ALA84
7	ALA87
7	ALA127
7	GLY130
7	TYR131
7	LEU133
7	HIS182
7	PHE183

---

site_id	AG6
Number of Residues	13
Details	binding site for residue HEM 7 404

Chain	Residue
7	TRP31
7	GLY34
7	LEU37
7	LEU94
7	HIS97
7	VAL98
7	SER106
7	GLY116
7	VAL117
7	LEU119
7	HIS196
7	LEU197
7	ASN206

---

site_id	AG7
Number of Residues	13
Details	binding site for residue CDL 8 401

Chain	Residue
7	SER29
7	LYS227
7	LEU230
7	GLY231
7	PHE234
8	LEU301
8	TYR305
8	LYS308
8	LYS316
9	GLN73
Aa	TYR30
Aa	VAL38
Aa	CDL101

---

site_id	AG8
Number of Residues	15
Details	binding site for residue HEC 8 402

Chain	Residue
8	VAL121
8	CYS122
8	SER124
8	CYS125
8	HIS126
8	ASN190
8	ALA193
8	LEU194
8	PRO196
8	ARG205
8	LEU215
8	LEU216
8	PHE238
8	ALA244
8	MET245

---

site_id	AG9
Number of Residues	11
Details	binding site for residue CDL Aa 101

Chain	Residue
7	SER29
7	TRP30
7	PHE33
7	PEE402
8	CDL401
Aa	TYR30
Aa	ASN37
Aa	VAL38
Aa	ARG41
Aa	THR42
Aa	CYS45

---

site_id	AH1
Number of Residues	23
Details	binding site for residue HEA Ak 601

Chain	Residue
Ak	GLY27
Ak	MET28
Ak	SER34
Ak	ILE37
Ak	ARG38
Ak	TYR54
Ak	VAL58
Ak	HIS61
Ak	ALA62
Ak	MET65
Ak	ILE66
Ak	VAL70
Ak	GLY125
Ak	TRP126
Ak	TYR371
Ak	PHE377
Ak	HIS378
Ak	SER382
Ak	PHE425
Ak	GLN428
Ak	ARG438
Ak	ARG439
Ak	MET468

---

site_id	AH2
Number of Residues	22
Details	binding site for residue HEA Ak 602

Chain	Residue
Ak	TRP126
Ak	TRP236
Ak	VAL243
Ak	TYR244
Ak	HIS290
Ak	HIS291
Ak	THR309
Ak	ALA313
Ak	THR316
Ak	GLY317
Ak	GLY352
Ak	LEU353
Ak	GLY355
Ak	ILE356
Ak	LEU358
Ak	ALA359
Ak	ASP364
Ak	HIS368
Ak	HIS376
Ak	PHE377
Ak	VAL380
Ak	ARG438

---

site_id	AH3
Number of Residues	3
Details	binding site for residue CU Ak 603

Chain	Residue
Ak	HIS240
Ak	HIS290
Ak	HIS291

---

site_id	AH4
Number of Residues	3
Details	binding site for residue MG Ak 604

Chain	Residue
Ak	HIS368
Ak	ASP369
Al	GLU198

---

site_id	AH5
Number of Residues	5
Details	binding site for residue CU Al 301

Chain	Residue
Al	HIS161
Al	CYS196
Al	CYS200
Al	MET207
Al	CU302

---

site_id	AH6
Number of Residues	5
Details	binding site for residue CU Al 302

Chain	Residue
Al	CYS196
Al	GLU198
Al	CYS200
Al	HIS204
Al	CU301

---

site_id	AH7
Number of Residues	4
Details	binding site for residue ZN Ap 101

Chain	Residue
Ap	CYS60
Ap	CYS62
Ap	CYS82
Ap	CYS85

---

Functional Information from PROSITE/UniProt

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
E	ASP166-PRO184

---

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
Ak	TRP236-HIS291

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
I	GLY172-PRO188

---

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
O	ASP107-MET122

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
O	ASP132-ILE144

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
D	GLU167-LEU188

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDALKLFtKE

Chain	Residue	Details
r	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
r	PRO197-GLY210

---

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryedsnnlGtSHLLRLAsSlTT

Chain	Residue	Details
6	GLY68-THR91

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
G	PRO61-CYS78

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS128-GLN140

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
G	ARG175-PHE185

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
Ap	VAL69-LEU91

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
C	LEU116-LYS127

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
Aq	ILE55-ASN72

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
B	GLY200-SER215

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
B	GLU377-GLY388

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
H	CYS113-PRO124
H	CYS152-PRO163

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
Al	VAL159-MET207

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
r	PHE2-LEU22
q	LEU351-PRO371
q	ILE391-THR413
q	ALA435-LEU455
l	TRP407-PHE429
l	LEU457-VAL477
l	MET482-LEU502
l	GLY582-PHE602
r	ILE68-PRO88
r	LEU100-GLY120
r	LEU146-ILE166
r	HIS171-ALA191
r	PHE223-LEU243
r	GLU253-ILE273
r	LEU294-ILE314
q	SER308-ALA330

---