5GUP
Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome c oxidase subunit 6C | polymer | 73 | 8495.0 | 1 | Sus scrofa (Pig) | ||
| 2 | B (B) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50637.8 | 1 | UniProt (F1RVN1) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) UniProt (by SIFTS) (A0A4X1SZP7) | Sus scrofa (Pig) | |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52552.3 | 1 | UniProt (F1S1A8) Pfam (PF00346) | Sus scrofa (Pig) | |
| 4 | D (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 264 | 30241.4 | 1 | UniProt (F1SIF2) | Sus scrofa (Pig) | |
| 5 | E (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 249 | 26301.6 | 1 | UniProt (F1SM98) Pfam (PF01257) | Sus scrofa (Pig) | |
| 6 | F (F) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 123 | 13349.0 | 1 | UniProt (F1S031) Pfam (PF10276) | Sus scrofa (Pig) | |
| 7 | G (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79627.4 | 1 | UniProt (F1SHD7) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) UniProt (by SIFTS) (A0A4X1V1H9) | Sus scrofa (Pig) | |
| 8 | H (H) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 23893.3 | 1 | Sus scrofa (Pig) | ||
| 9 | I (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 216 | 23777.7 | 1 | UniProt (I3LK43) Pfam (PF01058) UniProt (by SIFTS) (A0A8D1TL60) | Sus scrofa (Pig) | |
| 10 | J (J) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19718.5 | 1 | UniProt (G8IFA6) Pfam (PF04800) | Sus scrofa (Pig) | |
| 11 | K, R (K, R) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17162.4 | 2 | UniProt (F1SQP4) Pfam (PF05071) | Sus scrofa (Pig) | |
| 12 | L (L) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 377 | 42606.3 | 1 | UniProt (F1SL07) Pfam (PF01370) | Sus scrofa (Pig) | |
| 13 | M (M) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12648.6 | 1 | UniProt (F1SA62) | Sus scrofa (Pig) | |
| 14 | N (N) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13321.6 | 1 | UniProt (F1SLY2) | Sus scrofa (Pig) | |
| 15 | O, X (O, X) | Acyl carrier protein, mitochondrial | polymer | 156 | 17326.2 | 2 | UniProt (F1SAB6) | Sus scrofa (Pig) | |
| 16 | P (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 11099.8 | 1 | UniProt (F1RGE3) Pfam (PF05047) | Sus scrofa (Pig) | |
| 17 | Q (Q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 128 | 14953.3 | 1 | UniProt (F1SRG2) | Sus scrofa (Pig) | |
| 18 | S (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8088.4 | 1 | UniProt (K7GR43) Pfam (PF15879) | Sus scrofa (Pig) | |
| 19 | T (T) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9225.6 | 1 | UniProt (F1RNI5) Pfam (PF14987) UniProt (by SIFTS) (A0A4X1VPG4) | Sus scrofa (Pig) | |
| 20 | U (U) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 357 | 40476.1 | 1 | UniProt (F1SIS9) Pfam (PF01712) | Sus scrofa (Pig) | |
| 21 | V (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 141 | 14686.9 | 1 | UniProt (I3LGM4) Pfam (PF02466) | Sus scrofa (Pig) | |
| 22 | W (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16911.6 | 1 | UniProt (F1S6Q1) Pfam (PF06212) UniProt (by SIFTS) (A0A8D1NRT6) | Sus scrofa (Pig) | |
| 23 | Y (Y) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 105 | 11939.4 | 1 | UniProt (F1SRQ0) | Sus scrofa (Pig) | |
| 24 | Z (Z) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 98 | 11128.5 | 1 | UniProt (F1SI50) Pfam (PF08122) UniProt (by SIFTS) (A0A4X1VBN1) | Sus scrofa (Pig) | |
| 25 | AA (a) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21587.0 | 1 | UniProt (F1SGC6) Pfam (PF09781) | Sus scrofa (Pig) | |
| 26 | BA (b) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15603.2 | 1 | UniProt (Q2EN80) Pfam (PF09782) | Sus scrofa (Pig) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 |
| 27 | CA (c) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21702.5 | 1 | UniProt (F1RWL7) Pfam (PF05821) | Sus scrofa (Pig) | Complex I-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 28 | DA (d) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 20944.8 | 1 | UniProt (I3LDC3) Pfam (PF10249) | Sus scrofa (Pig) | |
| 29 | EA (e) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 154 | 17384.7 | 1 | UniProt (F1RWV4) | Sus scrofa (Pig) | |
| 30 | FA (f) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8630.0 | 1 | UniProt (F1RRC9) Pfam (PF14962) | Sus scrofa (Pig) | |
| 31 | GA (g) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 122 | 14327.7 | 1 | UniProt (F1STY1) | Sus scrofa (Pig) | |
| 32 | HA (h) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12506.6 | 1 | UniProt (F1SV23) Pfam (PF10200) | Sus scrofa (Pig) | |
| 33 | IA (i) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39077.5 | 1 | UniProt (O79875) Pfam (PF00361) Pfam (PF06444) | Sus scrofa (Pig) | NADH dehydrogenase subunit 2 |
| 34 | JA (j) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 12998.4 | 1 | UniProt (O79880) Pfam (PF00507) | Sus scrofa (Pig) | NADH dehydrogenase subunit 3 |
| 35 | KA (k) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10827.3 | 1 | UniProt (P56632) Pfam (PF00420) | Sus scrofa (Pig) | NADH dehydrogenase subunit 4L |
| 36 | LA (l) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68695.5 | 1 | UniProt (Q9TDR1) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Sus scrofa (Pig) | NADH dehydrogenase subunit 5 |
| 37 | MA (m) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19021.3 | 1 | UniProt (O79882) Pfam (PF00499) | Sus scrofa (Pig) | NADH dehydrogenase subunit 6 |
| 38 | NA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 58 | 7044.3 | 1 | UniProt (F1SD73) Pfam (PF08040) UniProt (by SIFTS) (A0A8D2CGH8) | Sus scrofa (Pig) | |
| 39 | OA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15117.4 | 1 | UniProt (I3LPW0) | Sus scrofa (Pig) | |
| 40 | PA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 21864.9 | 1 | UniProt (K7GSE5) Pfam (PF05347) | Sus scrofa (Pig) | |
| 41 | QA (q) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51859.4 | 1 | UniProt (O79881) Pfam (PF01059) Pfam (PF00361) | Sus scrofa (Pig) | NADH dehydrogenase subunit 4 |
| 42 | RA (r) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35667.5 | 1 | UniProt (O79874) Pfam (PF00146) | Sus scrofa (Pig) | NADH dehydrogenase subunit 1 |
| 43 | SA (s) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20064.1 | 1 | UniProt (F1SLR1) Pfam (PF06747) | Sus scrofa (Pig) | |
| 44 | TA (t) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16487.9 | 1 | Sus scrofa (Pig) | ||
| 45 | FB, UA (u, 5) | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 480 | 52756.3 | 2 | UniProt (F1SKM0) Pfam (PF00675) Pfam (PF05193) | Sus scrofa (Pig) | |
| 46 | GB, VA (v, 6) | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 453 | 48264.5 | 2 | Sus scrofa (Pig) | ||
| 47 | HB, WA (w, 7) | Cytochrome b | polymer | 379 | 42840.7 | 2 | UniProt (Q1HBG9) Pfam (PF00032) Pfam (PF00033) | Sus scrofa (Pig) | |
| 48 | IB, XA (x, 8) | Cytochrome c1, heme protein, mitochondrial | polymer | 326 | 35488.9 | 2 | Sus scrofa (Pig) | ||
| 49 | JB, YA (y, 9) | Cytochrome b-c1 complex subunit 7 | polymer | 111 | 13587.5 | 2 | Sus scrofa (Pig) | ||
| 50 | KB, ZA (z, Aa) | Cytochrome b-c1 complex subunit 8 | polymer | 82 | 9784.3 | 2 | UniProt (F1RI18) Pfam (PF02939) UniProt (by SIFTS) (A0A4X1UYT9) | Sus scrofa (Pig) | |
| 51 | AB, LB (0, Ab) | Cytochrome b-c1 complex subunit 6, mitochondrial | polymer | 91 | 10685.8 | 2 | UniProt (F1S3W0) Pfam (PF02320) | Sus scrofa (Pig) | |
| 52 | BB, MB (1, Ac) | Cytochrome b-c1 complex subunit 9 | polymer | 64 | 7412.5 | 2 | UniProt (Q2EN79) Pfam (PF05365) | Sus scrofa (Pig) | |
| 53 | CB, EB (2, 4) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 274 | 29492.6 | 2 | UniProt (F1RNZ1) Pfam (PF09165) Pfam (PF02921) Pfam (PF00355) | Sus scrofa (Pig) | |
| 54 | DB, NB (3, Ad) | Cytochrome b-c1 complex subunit 10 | polymer | 56 | 6560.7 | 2 | UniProt (F1SDI2) Pfam (PF08997) | Sus scrofa (Pig) | |
| 55 | OB, PB (Ae, Af) | Cytochrome b-c1 complex subunit Rieske transit peptide, mitochondrial | polymer | 78 | 7900.1 | 2 | UniProt (F1RNZ1) Pfam (PF09165) | Sus scrofa (Pig) | |
| 56 | QB (Ag) | Cytochrome c oxidase subunit 8B, mitochondrial | polymer | 46 | 4967.8 | 1 | Sus scrofa (Pig) | ||
| 57 | RB (Ah) | Cytochrome c oxidase subunit 7A1, mitochondrial | polymer | 59 | 6682.7 | 1 | Sus scrofa (Pig) | ||
| 58 | SB (Ai) | Cytochrome c oxidase subunit 7B, mitochondrial | polymer | 56 | 6365.2 | 1 | Sus scrofa (Pig) | ||
| 59 | TB (Aj) | Cytochrome c oxidase subunit 7C, mitochondrial | polymer | 47 | 5449.4 | 1 | Sus scrofa (Pig) | ||
| 60 | UB (Ak) | Cytochrome c oxidase subunit 1 | polymer | 514 | 57065.8 | 1 | Sus scrofa (Pig) | ||
| 61 | VB (Al) | Cytochrome c oxidase subunit 2 | polymer | 227 | 26040.4 | 1 | Sus scrofa (Pig) | ||
| 62 | WB (Am) | Cytochrome c oxidase subunit 3 | polymer | 261 | 29943.6 | 1 | Sus scrofa (Pig) | ||
| 63 | XB (An) | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | polymer | 147 | 17179.6 | 1 | Sus scrofa (Pig) | ||
| 64 | YB (Ao) | Cytochrome c oxidase subunit 5A, mitochondrial | polymer | 109 | 12453.1 | 1 | UniProt (F1SJ34) Pfam (PF02284) | Sus scrofa (Pig) | |
| 65 | ZB (Ap) | Cytochrome c oxidase subunit 5B, mitochondrial | polymer | 98 | 10684.0 | 1 | Sus scrofa (Pig) | ||
| 66 | AC (Aq) | Cytochrome c oxidase subunit 6A, mitochondrial | polymer | 84 | 9452.7 | 1 | Sus scrofa (Pig) | ||
| 67 | BC (Ar) | Cytochrome c oxidase subunit 6B1 | polymer | 85 | 10039.2 | 1 | Sus scrofa (Pig) | ||
| 68 | CC, FC, GC, IC, JC... (B, G, H, I) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 69 | DC (B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 70 | EC, HC, JD, LD (E, G, 2, 4) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) | |||
| 71 | HD, KC, KD, PC, TC (2, H, 4, V, i) | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL | non-polymer | 767.1 | 5 | Chemie (PLX) | |||
| 72 | MC (L) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 73 | NC, RC (Q, X) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) | |||
| 74 | FD, GD, MD, OC, SD... (x, z, 5, V, 8...) | CARDIOLIPIN | non-polymer | 1464.0 | 10 | Chemie (CDL) | |||
| 75 | AD, DD, ID, ND, OD... (u, w, 2, 5, 7...) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 10 | Chemie (PEE) | |||
| 76 | BD, CD, QD, RD (w, 7) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 77 | ED, TD (x, 8) | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 78 | VD, WD (Ak) | HEME-A | non-polymer | 852.8 | 2 | Chemie (HEA) | |||
| 79 | AE, XD, ZD (Al, Ak) | COPPER (II) ION | non-polymer | 63.5 | 3 | Chemie (CU) | |||
| 80 | YD (Ak) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 81 | BE (Ap) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 80 |
| Total formula weight | 1781941.0 | |
| Non-Polymers* | Number of molecules | 52 |
| Total formula weight | 36757.7 | |
| All* | Total formula weight | 1818698.7 |
