8OI0
| Structure of the Fmoc-Tau-PAM4 Type 4 amyloid fibril | 分子名称: | Microtubule-associated protein tau | 著者 | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | 登録日 | 2023-03-21 | 公開日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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2RTV
| Tachyplesin I in water | 分子名称: | Tachyplesin-1 | 著者 | Kushibiki, T, Kamiya, M, Aizawa, T, Kumaki, Y, Kikukawa, T, Mizuguchi, M, Demura, M, Kawabata, S.I, Kawano, K. | 登録日 | 2013-09-19 | 公開日 | 2014-02-19 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide. Biochim.Biophys.Acta, 1844, 2014
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5VEG
| Structure of a Short-Chain Flavodoxin Associated with a Non-Canonical PDU Bacterial Microcompartment | 分子名称: | CADMIUM ION, FLAVIN MONONUCLEOTIDE, Flavodoxin, ... | 著者 | Sutter, M, Plegaria, J.S, Kerfeld, C.A. | 登録日 | 2017-04-04 | 公開日 | 2017-10-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural and Functional Characterization of a Short-Chain Flavodoxin Associated with a Noncanonical 1,2-Propanediol Utilization Bacterial Microcompartment. Biochemistry, 56, 2017
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6HAL
| Human carbonmonoxy hemoglobin SFX dataset | 分子名称: | CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Doak, B, Gorel, A, Foucar, L, Barends, T.R.M, Gruenbein, M.L, Hilpert, M, Kloos, M, Nass Kovacs, G, Roome, C.M, Shoeman, R.L, Stricker, M, Tono, K, You, D, Ueda, K, Sherrell, D.A, Owen, R.L, Schlichting, I. | 登録日 | 2018-08-07 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystallography on a chip - without the chip: sheet-on-sheet sandwich. Acta Crystallogr D Struct Biol, 74, 2018
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8JZ8
| Subatomic structure of orthorhombic thaumatin at 0.89 Angstroms | 分子名称: | DI(HYDROXYETHYL)ETHER, Thaumatin I | 著者 | Masuda, T, Suzuki, M, Yamasaki, M, Mikami, B. | 登録日 | 2023-07-04 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (0.89 Å) | 主引用文献 | Subatomic structure of orthorhombic thaumatin at 0.89 angstrom reveals that highly flexible conformations are crucial for thaumatin sweetness. Biochem.Biophys.Res.Commun., 703, 2024
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5VYK
| Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1 | 分子名称: | Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL | 著者 | Maisonneuve, P, Kurinov, I, Marullo, S.A, Lavoie, H, Thevakumaran, N, Sahmi, M, Jin, T, Therrien, M, SIcheri, F. | 登録日 | 2017-05-25 | 公開日 | 2018-02-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | MEK drives BRAF activation through allosteric control of KSR proteins. Nature, 554, 2018
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8DTU
| The complex of nanobody 5344N74D with BCL11A ZF6. | 分子名称: | B-cell lymphoma/leukemia 11A, Nanobody 5344N74D, ZINC ION | 著者 | Yin, M, Tenglin, K, Zhai, L, Dassama, L.M, Orkin, S.H. | 登録日 | 2022-07-26 | 公開日 | 2023-02-01 | 実験手法 | X-RAY DIFFRACTION (2.447 Å) | 主引用文献 | Evolution of nanobodies specific for BCL11A. Proc.Natl.Acad.Sci.USA, 120, 2023
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6T8Q
| HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide | 分子名称: | (2~{R})-1-[6-methyl-5-(oxan-4-yl)-7-oxidanylidene-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-~{N}-(phenylmethyl)pyrrolidine-2-carboxamide, ACETATE ION, CADMIUM ION, ... | 著者 | Blaesse, M, Venalainen, J. | 登録日 | 2019-10-24 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
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6CRG
| Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099 | 分子名称: | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, GLYCEROL, SULFATE ION, ... | 著者 | Stams, T, Fodor, M. | 登録日 | 2018-03-17 | 公開日 | 2018-11-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9, 2018
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5ND6
| Crystal structure of apo transketolase from Chlamydomonas reinhardtii | 分子名称: | 1,2-ETHANEDIOL, Transketolase | 著者 | Fermani, S, Zaffagnini, M, Francia, F, Pasquini, M. | 登録日 | 2017-03-07 | 公開日 | 2017-06-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structural basis for the magnesium-dependent activation of transketolase from Chlamydomonas reinhardtii. Biochim. Biophys. Acta, 1861, 2017
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1WHE
| COAGULATION FACTOR, NMR, 20 STRUCTURES | 分子名称: | COAGULATION FACTOR X | 著者 | Sunnerhagen, M, Olah, G.A, Stenflo, J, Forsen, S, Drakenberg, T, Trewhella, J. | 登録日 | 1996-06-18 | 公開日 | 1997-05-15 | 最終更新日 | 2017-11-29 | 実験手法 | SOLUTION NMR | 主引用文献 | The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study. Biochemistry, 35, 1996
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5KZ0
| Structure of Human Anaplastic Lymphoma Kinase in Complex With 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide | 分子名称: | 2-[(1~{R})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl)pyridin-3-yl]oxyethyl]-4-fluoranyl-~{N},~{N}-dimethyl-benzamide, ALK tyrosine kinase receptor | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2016-07-22 | 公開日 | 2016-08-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. J. Med. Chem., 57, 2014
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6TBE
| LC3A in complex with (3R,4S,5R,6R)-5-hydroxy-6-((4-hydroxy-3-(4-hydroxy-3-isopentylbenzamido)-8-methyl-2-oxo-2H-chromen-7-yl)oxy)-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate | 分子名称: | 1,2-ETHANEDIOL, Microtubule-associated proteins 1A/1B light chain 3A, NOVOBIOCIN | 著者 | Kramer, J.S, Pogoryelov, D, Hartmann, M, Chaikuad, A, Proschak, E. | 登録日 | 2019-11-01 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.67008042 Å) | 主引用文献 | Demonstrating Ligandability of the LC3A and LC3B Adapter Interface. J.Med.Chem., 64, 2021
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6CYM
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6TOS
| Crystal structure of the Orexin-1 receptor in complex with GSK1059865 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CITRIC ACID, Orexin receptor type 1, ... | 著者 | Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A. | 登録日 | 2019-12-11 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis. J.Med.Chem., 63, 2020
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2RPP
| Solution structure of Tandem zinc finger domain 12 in Muscleblind-like protein 2 | 分子名称: | Muscleblind-like protein 2, ZINC ION | 著者 | Abe, C, Dang, W, Tsuda, K, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2008-06-24 | 公開日 | 2009-05-12 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the RNA binding domain in the human muscleblind-like protein 2 Protein Sci., 18, 2009
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6CP6
| Monomer yeast ATP synthase (F1Fo) reconstituted in nanodisc. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase protein 8, ... | 著者 | Srivastava, A.P, Luo, M, Symersky, J, Liao, M.F, Mueller, D.M. | 登録日 | 2018-03-13 | 公開日 | 2018-04-11 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane. Science, 360, 2018
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2RRA
| Solution structure of RNA binding domain in human Tra2 beta protein in complex with RNA (GAAGAA) | 分子名称: | 5'-R(*GP*AP*AP*GP*AP*A)-3', cDNA FLJ40872 fis, clone TUTER2000283, ... | 著者 | Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2010-06-17 | 公開日 | 2011-04-27 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM. Nucleic Acids Res., 39, 2011
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2RT9
| Solution structure of a regulatory domain of meiosis inhibitor | 分子名称: | F-box only protein 43, ZINC ION | 著者 | Shoji, S, Muto, Y, Ikeda, M, He, F, Tsuda, K, Ohsawa, N, Akasaka, R, Terada, T, Wakiyama, M, Shirouzu, M, Yokoyama, S. | 登録日 | 2013-07-05 | 公開日 | 2014-07-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation FEBS Open Bio, 4, 2014
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7KZE
| Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity | 分子名称: | 1-benzyl-4-methoxybenzene, Leukotriene A-4 hydrolase, TRIETHYLENE GLYCOL, ... | 著者 | Lee, K.H, Shim, Y, Paige, M, Noble, S.M. | 登録日 | 2020-12-10 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Substrate-dependent modulation of the leukotriene A 4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation. Sci Rep, 12, 2022
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6JNR
| RXRa structure complexed with CU-6PMN and SRC1 peptide. | 分子名称: | 7-oxidanyl-2-oxidanylidene-6-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)chromene-3-carboxylic acid, HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, Retinoic acid receptor RXR-alpha | 著者 | Kawasaki, M, Nakano, S, Motoyama, T, Yamada, S, Watanabe, M, Takamura, Y, Fujihara, M, Tokiwa, H, Kakuta, H, Ito, S. | 登録日 | 2019-03-18 | 公開日 | 2020-03-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | RXRa structure complexed with CU-6PMN and SRC1 peptide. To Be Published
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2RR4
| Complex structure of the zf-CW domain and the H3K4me3 peptide | 分子名称: | Histone H3, ZINC ION, Zinc finger CW-type PWWP domain protein 1 | 著者 | He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2010-03-24 | 公開日 | 2010-09-15 | 最終更新日 | 2011-07-13 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural insight into the zinc finger CW domain as a histone modification reader Structure, 18, 2010
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7QV6
| Amyloid fibril from the antimicrobial peptide aurein 3.3 | 分子名称: | Aurein-3.3 | 著者 | Buecker, R, Seuring, C, Cazey, C, Veith, K, Garcia-Alai, M, Gruenewald, K, Landau, M. | 登録日 | 2022-01-19 | 公開日 | 2022-06-29 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | The Cryo-EM structures of two amphibian antimicrobial cross-beta amyloid fibrils. Nat Commun, 13, 2022
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2RSY
| Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp | 分子名称: | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK | 著者 | Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T. | 登録日 | 2012-09-10 | 公開日 | 2013-04-10 | 最終更新日 | 2019-12-25 | 実験手法 | SOLUTION NMR | 主引用文献 | Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains. J.Biol.Chem., 288, 2013
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7QV5
| Amyloid fibril from the antimicrobial peptide uperin 3.5 | 分子名称: | Uperin-3.5 | 著者 | Buecker, R, Seuring, C, Cazey, C, Veith, K, Garcia-Alai, M, Gruenewald, K, Landau, M. | 登録日 | 2022-01-19 | 公開日 | 2022-06-29 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The Cryo-EM structures of two amphibian antimicrobial cross-beta amyloid fibrils. Nat Commun, 13, 2022
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