1A5S
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![BU of 1a5s by Molmil](/molmil-images/mine/1a5s) | CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE AND L-SER BOUND AS AMINO ACRYLATE TO THE BETA SITE | 分子名称: | 5-FLUOROINDOLE PROPANOL PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SERINE, ... | 著者 | Schneider, T.R, Gerhardt, E, Lee, M, Liang, P.-H, Anderson, K.S, Schlichting, I. | 登録日 | 1998-02-17 | 公開日 | 1999-03-30 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Loop closure and intersubunit communication in tryptophan synthase. Biochemistry, 37, 1998
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8Q7Z
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8TVK
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8TXK
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6AAZ
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![BU of 6aaz by Molmil](/molmil-images/mine/6aaz) | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pNO2ZLys | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, MAGNESIUM ION, ... | 著者 | Yanagisawa, T, Kuratani, M, Yokoyama, S. | 登録日 | 2018-07-19 | 公開日 | 2019-04-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.842 Å) | 主引用文献 | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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9EQJ
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![BU of 9eqj by Molmil](/molmil-images/mine/9eqj) | Crystal structure of pVHL:EloB:EloC in complex with MP-1-39 | 分子名称: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[cis-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | 登録日 | 2024-03-21 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity. Bioorg.Med.Chem.Lett., 110, 2024
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8ZMF
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![BU of 8zmf by Molmil](/molmil-images/mine/8zmf) | Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C | 分子名称: | 1-[(4-fluorophenyl)methyl]-1-[(8~{S})-5-methyl-5-azaspiro[2.5]octan-8-yl]-3-[[4-(2-methylpropoxy)phenyl]methyl]urea, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 | 著者 | Oguma, T, Asada, H, Sekiguchi, Y, Imono, M, Iwata, S, Kusakabe, K. | 登録日 | 2024-05-23 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. J.Med.Chem., 2024
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6AB6
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![BU of 6ab6 by Molmil](/molmil-images/mine/6ab6) | Cryo-EM structure of T=3 Penaeus vannamei nodavirus | 分子名称: | CALCIUM ION, Capsid protein | 著者 | Chen, N.C, Miyazaki, N, Yoshimura, M, Guan, H.H, Lin, C.C, Iwasaki, K, Chen, C.J. | 登録日 | 2018-07-20 | 公開日 | 2019-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism. Commun Biol, 2, 2019
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6AKP
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![BU of 6akp by Molmil](/molmil-images/mine/6akp) | Crystal Structural of FOXC2 DNA binding domain bound to PC promoter | 分子名称: | DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION | 著者 | Chen, X, Wei, H, Li, J, Liang, X, Dai, S, Jiang, L, Guo, M, Chen, Y. | 登録日 | 2018-09-03 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.323 Å) | 主引用文献 | Structural basis for DNA recognition by FOXC2. Nucleic Acids Res., 47, 2019
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6AMC
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6A5O
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![BU of 6a5o by Molmil](/molmil-images/mine/6a5o) | RNA polymerase II elongation complex stalled at SHL(-6) of the nucleosome | 分子名称: | DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | 著者 | Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. | 登録日 | 2018-06-25 | 公開日 | 2018-10-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (9.9 Å) | 主引用文献 | Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
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8RFZ
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8RG2
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8RII
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6AB8
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![BU of 6ab8 by Molmil](/molmil-images/mine/6ab8) | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with ZLys | 分子名称: | (2S)-2-azanyl-6-(phenylmethoxycarbonylamino)hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Yanagisawa, T, Kuratani, M, Yokoyama, S. | 登録日 | 2018-07-20 | 公開日 | 2019-04-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.753 Å) | 主引用文献 | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AJV
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![BU of 6ajv by Molmil](/molmil-images/mine/6ajv) | Crystal structure of BRD4 in complex with isoliquiritigenin and DMSO (Cocktail No. 3) | 分子名称: | 2',4,4'-TRIHYDROXYCHALCONE, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... | 著者 | Yokoyama, T, Matsumoto, K, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-08-28 | 公開日 | 2019-06-12 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4. Febs J., 286, 2019
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6ACC
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6AEG
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![BU of 6aeg by Molmil](/molmil-images/mine/6aeg) | Crystal structure of xCas9 in complex with sgRNA and target DNA (GAT PAM) | 分子名称: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*GP*AP*TP*TP*AP*TP*TP*G)-3'), DNA nuclease, ... | 著者 | Guo, M, Ren, K, Zhu, Y, Huang, Z. | 登録日 | 2018-08-04 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Structural insights into a high fidelity variant of SpCas9. Cell Res., 29, 2019
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8TWX
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8TY2
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8TY8
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6ACD
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8TY9
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8W7A
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![BU of 8w7a by Molmil](/molmil-images/mine/8w7a) | Cryo-EM structure of ClassIII Lanthipeptide modification enzyme PneKC in the presence of GTP. | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Protein kinase domain-containing protein | 著者 | Li, Y, Luo, M, Shao, K, Li, J. | 登録日 | 2023-08-30 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers. Nat Commun, 15, 2024
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8W7J
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![BU of 8w7j by Molmil](/molmil-images/mine/8w7j) | Cryo-EM structure of ClassIII Lanthipeptide modification enzyme PneKC with chain A bounded to substrate PneA and GTP. | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, PneA LP, ... | 著者 | Li, Y, Luo, M, Shao, K, Li, J, Li, Z. | 登録日 | 2023-08-30 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers. Nat Commun, 15, 2024
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