8GYI
 
 | | Crystal structure of Fic25 (holo form) from Streptomyces ficellus | | 分子名称: | DegT/DnrJ/EryC1/StrS family aminotransferase, GLYCEROL, IMIDAZOLE, ... | | 著者 | Kurosawa, S, Yoshida, A, Tomita, T, Nishiyama, M. | | 登録日 | 2022-09-22 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis.
Acs Chem.Biol., 18, 2023
|
|
3AOX
 | | X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802 | | 分子名称: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, ALK tyrosine kinase receptor | | 著者 | Nagel, S, Moertl, M, Jestel, A, Fukami, T.A. | | 登録日 | 2010-10-08 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
Cancer Cell, 19, 2011
|
|
8GYJ
 | | Crystal structure of Fic25 complexed with PLP-(5S,6S)-N2-acetyl-DADH adduct from Streptomyces ficellus | | 分子名称: | (2~{S},5~{S},6~{S})-2-acetamido-6-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]-5,7-bis(oxidanyl)heptanoic acid, DegT/DnrJ/EryC1/StrS family aminotransferase, GLYCEROL, ... | | 著者 | Kurosawa, S, Yoshida, A, Tomita, T, Nishiyama, M. | | 登録日 | 2022-09-22 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis.
Acs Chem.Biol., 18, 2023
|
|
5YP1
 | | Crystal structure of dipeptidyl peptidase IV (DPP IV) from Pseudoxanthomonas mexicana WO24 | | 分子名称: | Dipeptidyl aminopeptidase 4, GLYCEROL | | 著者 | Roppongi, S, Suzuki, Y, Tateoka, C, Fuimoto, M, Morisawa, S, Iizuka, I, Nakamura, A, Honma, N, Shida, Y, Ogasawara, W, Tanaka, N, Sakamoto, Y, Nonaka, T. | | 登録日 | 2017-11-01 | | 公開日 | 2018-02-21 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues.
Sci Rep, 8, 2018
|
|
6QXH
 | |
6QYA
 | |
1M15
 | | Transition state structure of arginine kinase | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ARGININE, MAGNESIUM ION, ... | | 著者 | Yousef, M.S, Fabiola, F, Gattis, J.L, Somasundaram, T, Chapman, M.S. | | 登録日 | 2002-06-17 | | 公開日 | 2002-12-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Refinement of the arginine kinase transition-state analogue complex at 1.2 A resolution: mechanistic insights.
Acta Crystallogr.,Sect.D, 58, 2002
|
|
8VTT
 | | Meis1 homeobox domain bound to neomycin fragment | | 分子名称: | Homeobox protein Meis1, RIBOSTAMYCIN, SULFATE ION | | 著者 | Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N, Sadek, H.A. | | 登録日 | 2024-01-27 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Identification of FDA-approved drugs that induce heart regeneration in mammals.
Nat Cardiovasc Res, 3, 2024
|
|
8VTS
 | | Meis1 homeobox domain bound to paromomycin fragment | | 分子名称: | 1,2-ETHANEDIOL, Homeobox protein Meis1, ISOPROPYL ALCOHOL, ... | | 著者 | Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N. | | 登録日 | 2024-01-27 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Identification of FDA-approved drugs that induce heart regeneration in mammals.
Nat Cardiovasc Res, 3, 2024
|
|
8RAO
 | |
8R53
 | | The complex of Glycogen Phosphorylase with (-)-Epigallocatechin-3-gallate (EGCG) and glucose. | | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | | 著者 | Alexopoulos, S, Papakostopoulou, S, Koulas, M.S, Leonidas, D.D, Skamnaki, V. | | 登録日 | 2023-11-15 | | 公開日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Evidence for the Quercetin Binding Site of Glycogen Phosphorylase as a Target for Liver-Isoform-Selective Inhibitors against Glioblastoma: Investigation of Flavanols Epigallocatechin Gallate and Epigallocatechin.
J.Agric.Food Chem., 2024
|
|
8R6V
 | | The complex of glycogen phosphorylase with EGCG (epigallocatechin gallate) and caffeine. | | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, CAFFEINE, DIMETHYL SULFOXIDE, ... | | 著者 | Alexopoulos, S, Papakostopoulou, S, Koulas, M.S, Leonidas, D.D, Skamnaki, V. | | 登録日 | 2023-11-23 | | 公開日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Evidence for the Quercetin Binding Site of Glycogen Phosphorylase as a Target for Liver-Isoform-Selective Inhibitors against Glioblastoma: Investigation of Flavanols Epigallocatechin Gallate and Epigallocatechin.
J.Agric.Food Chem., 2024
|
|
8RAP
 | |
6QXG
 | |
8RAM
 | |
6QXS
 | | Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with FdUMP | | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, SULFATE ION, ... | | 著者 | Pozzi, C, Mangani, M. | | 登録日 | 2019-03-07 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules, 24, 2019
|
|
8SK6
 | | human liver mitochondrial Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase | | 分子名称: | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial | | 著者 | Zhang, Z, Tringides, M. | | 登録日 | 2023-04-18 | | 公開日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
|
|
8HEF
 | | The Crystal structure of deuterated S-217622 (Ensitrelvir) bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 | | 分子名称: | 3C-like proteinase, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, GLYCEROL | | 著者 | Yan, M, Zhang, H. | | 登録日 | 2022-11-08 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2.
Antiviral Res., 213, 2023
|
|
5YP6
 | | RORgamma (263-509) complexed with SRC2 and Compound 6 | | 分子名称: | N-[3'-cyano-4'-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, SRC2 | | 著者 | Gao, M, Cai, W. | | 登録日 | 2017-11-01 | | 公開日 | 2018-02-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
|
|
3AV2
 | | The human nucleosome structure containing the histone variant H3.3 | | 分子名称: | 146-MER DNA, Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Tachiwana, H, Osakabe, A, Shiga, T, Miya, M, Kimura, H, Kagawa, W, Kurumizaka, H. | | 登録日 | 2011-02-18 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structures of human nucleosomes containing major histone H3 variants
Acta Crystallogr.,Sect.D, 67, 2011
|
|
6QTL
 | |
3OT7
 | | Escherichia coli apo-manganese superoxide dismutase | | 分子名称: | Superoxide dismutase [Mn] | | 著者 | Whittaker, M.M, Lerch, T.F, Kirillova, O, Chapman, M.S, Whittaker, J.W. | | 登録日 | 2010-09-10 | | 公開日 | 2010-12-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Subunit dissociation and metal binding by Escherichia coli apo-manganese superoxide dismutase.
Arch.Biochem.Biophys., 505, 2011
|
|
7COJ
 | | Crystal structure of the b-carbonic anhydrase CafA of the fungal pathogen Aspergillus fumigatus | | 分子名称: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase, ZINC ION | | 著者 | Jin, M.S, Kim, S, Yeon, J, Sung, J. | | 登録日 | 2020-08-04 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of beta-Carbonic Anhydrase CafA from the Fungal Pathogen Aspergillus fumigatus .
Mol.Cells, 43, 2020
|
|
5Y0B
 | | PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99 | | 分子名称: | Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta | | 著者 | Abe, K, Shimokawa, J, Natio, M, Munson, K, Vagin, O, Sachs, G, Suzuki, H, Tani, K, Fujiyoshi, Y. | | 登録日 | 2017-07-16 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (6.5 Å) | | 主引用文献 | The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors
Sci Rep, 7, 2017
|
|
8VI4
 | | TehA from Haemophilus influenzae purified in LMNG | | 分子名称: | Tellurite resistance protein TehA homolog | | 著者 | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | | 登録日 | 2024-01-03 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy.
Int J Mol Sci, 25, 2024
|
|
