6QXS

Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with FdUMP

Summary for 6QXS

• Entry DOI: 10.2210/pdb6qxs/pdb
• Related: 6QXG 6QXH
• Descriptor: Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: enteroccocus faecalis thymidylate synthase, efts, folate pathway, inhibitor, fdump, transferase
• Biological source: Enterococcus faecalis (strain ATCC 700802 / V583); More
• Total number of polymer chains: 4
• Total formula weight: 147411.37

Authors

Pozzi, C.,Mangani, M. (deposition date: 2019-03-07, release date: 2019-04-10, Last modification date: 2024-01-24)

• Primary citation: Pozzi, C.,Ferrari, S.,Luciani, R.,Tassone, G.,Costi, M.P.,Mangani, S.; Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.; Molecules, 24:-, 2019; PubMed: 30935102; DOI: 10.3390/molecules24071257

Experimental method

X-RAY DIFFRACTION (2.88 Å)