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PDB: 51630 件

6AVQ
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The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance
分子名称: Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ...
著者Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D.
登録日2017-09-04
公開日2017-11-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (35 Å)
主引用文献The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
6AVR
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Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609
分子名称: Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ...
著者Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D.
登録日2017-09-04
公開日2017-11-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (35 Å)
主引用文献The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
1ABA
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THE STRUCTURE OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXIN (THIOREDOXIN). REFINEMENT OF NATIVE AND MUTANT PROTEINS
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTAREDOXIN
著者Eklund, H, Ingelman, M, Soderberg, B.-O, Uhlin, T, Nordlund, P, Nikkola, M, Sonnerstam, U, Joelson, T, Petratos, K.
登録日1992-04-24
公開日1993-10-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure of oxidized bacteriophage T4 glutaredoxin (thioredoxin). Refinement of native and mutant proteins.
J.Mol.Biol., 228, 1992
1AAZ
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THE STRUCTURE OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXIN (THIOREDOXIN)
分子名称: CADMIUM ION, GLUTAREDOXIN
著者Eklund, H, Ingelman, M, Soderberg, B.-O, Uhlin, T, Nordlund, P, Nikkola, M, Sonnerstam, U, Joelson, T, Petratos, K.
登録日1992-04-24
公開日1993-10-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of oxidized bacteriophage T4 glutaredoxin (thioredoxin). Refinement of native and mutant proteins.
J.Mol.Biol., 228, 1992
4Q97
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IgNAR antibody domain C1
分子名称: Novel antigen receptor
著者Feige, J.M, Graewert, M.A, Marcinowski, M, Hennig, J, Behnke, J, Auslaender, D, Herold, E.M, Peschek, J, Castro, C.D, Flajnik, M.F, Hendershot, L.M, Sattler, M, Groll, M, Buchner, J.
登録日2014-04-29
公開日2014-07-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.
Proc.Natl.Acad.Sci.USA, 111, 2014
7W3W
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X-ray structure of apo-VmFbpA, a ferric ion-binding protein from Vibrio metschnikovii
分子名称: Iron-utilization periplasmic protein
著者Lu, P, Sui, M, Zhang, M, Nagata, K.
登録日2021-11-26
公開日2021-12-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.858 Å)
主引用文献Rosmarinic Acid and Sodium Citrate Have a Synergistic Bacteriostatic Effect against Vibrio Species by Inhibiting Iron Uptake.
Int J Mol Sci, 22, 2021
3E3U
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Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor
分子名称: N-[(2R)-2-{[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl}hexyl]-N-hydroxyformamide, NICKEL (II) ION, Peptide deformylase
著者Meng, W, Xu, M, Pan, S, Koehn, J.
登録日2008-08-08
公開日2009-01-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results.
Bioorg.Med.Chem.Lett., 18, 2008
4QL1
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Crystal structure of human WDR5 in complex with compound OICR-9429
分子名称: 1,2-ETHANEDIOL, GLYCEROL, N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ...
著者Dong, A, Dombrovski, L, Walker, J.R, Getlik, M, Kuznetsova, E, Smil, D, Barsyte, D, Li, F, Poda, G, Senisterra, G, Marcellus, R, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
登録日2014-06-10
公開日2014-12-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Pharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia.
Nat.Chem.Biol., 11, 2015
7Z8O
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Crystal structure of SARS-CoV-2 S RBD in complex with a stapled peptide
分子名称: 2,4,6-tris(chloromethyl)-1,3,5-triazine, GLYCEROL, Spike protein S1, ...
著者Brear, P, Chen, L, Gaynor, K, Harman, M, Dods, R, Hyvonen, M.
登録日2022-03-18
公開日2023-06-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (0.96 Å)
主引用文献Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Nat Commun, 14, 2023
7Z0U
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Crystal structure of AtWRKY18 DNA-binding domain in complex with W-box DNA
分子名称: DNA (5'-D(*CP*GP*CP*CP*TP*TP*GP*AP*CP*CP*AP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*CP*TP*GP*GP*TP*CP*AP*AP*GP*GP*CP*G)-3'), WRKY transcription factor 18, ...
著者Grzechowiak, M, Jaskolski, M, Ruszkowski, M.
登録日2022-02-23
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献New aspects of DNA recognition by group II WRKY transcription factor revealed by structural and functional study of AtWRKY18 DNA binding domain.
Int.J.Biol.Macromol., 213, 2022
7Z0R
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AtWRKY18 DNA-binding domain
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, NITRATE ION, ...
著者Grzechowiak, M, Jaskolski, M, Ruszkowski, M.
登録日2022-02-23
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献New aspects of DNA recognition by group II WRKY transcription factor revealed by structural and functional study of AtWRKY18 DNA binding domain.
Int.J.Biol.Macromol., 213, 2022
3E95
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Crystal Structure of the Plasmodium Falciparum ubiquitin conjugating enzyme complex, PfUBC13-PfUev1a
分子名称: UNKNOWN ATOM OR ION, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2
著者Wernimont, A.K, Lam, A, Ali, A, Brokx, S, Lin, Y.H, Zhao, Y, Lew, J, Ravichandran, M, Wasney, G, Vedadi, M, Kozieradzki, I, Schapira, M, Bochkarev, A, Wilkstrom, M, BOuntra, C, Arrowsmith, C.H, Edwards, A.M, Hui, R, Qiu, W, Brand, V.B, Structural Genomics Consortium (SGC)
登録日2008-08-21
公開日2008-09-30
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of the Plasmodium Falciparum ubiquitin conjugating enzyme complex, PfUBC13-PfUev1a
TO BE PUBLISHED
3CHO
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BU of 3cho by Molmil
Crystal structure of leukotriene a4 hydrolase in complex with 2-amino-N-[4-(phenylmethoxy)phenyl]-acetamide
分子名称: ACETATE ION, Leukotriene A-4 hydrolase, N-[4-(benzyloxy)phenyl]glycinamide, ...
著者Thunnissen, M.M.G.M, Adler, M, Whitlow, M.
登録日2008-03-10
公開日2008-04-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHP
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Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid
分子名称: (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid, ACETATE ION, IMIDAZOLE, ...
著者Thunnissen, M.M.G.M, Adler, M, Whitlow, M.
登録日2008-03-10
公開日2008-04-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
6UKN
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Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
分子名称: CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 7, ...
著者Reid, M.S, Kern, D.M, Brohawn, S.G.
登録日2019-10-05
公開日2020-06-10
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
Elife, 9, 2020
7NE1
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Structure of the complex between Netrin-1 and its receptor Neogenin
分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C.
登録日2021-02-02
公開日2021-03-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
7NDG
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Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ...
著者Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C.
登録日2021-02-01
公開日2021-03-31
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (5.98 Å)
主引用文献Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
7NE0
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Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin
分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C.
登録日2021-02-02
公開日2021-03-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
6OBN
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The crystal structure of coexpressed SDS22:PP1 complex
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FE (III) ION, ...
著者Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R.
登録日2019-03-21
公開日2019-09-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献SDS22 selectively recognizes and traps metal-deficient inactive PP1.
Proc.Natl.Acad.Sci.USA, 116, 2019
3AP3
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Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP
分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Protein-tyrosine sulfotransferase 2
著者Teramoto, T, Fujikawa, Y, Kawaguchi, Y, Kurogi, K, Soejima, M, Adachi, R, Nakanishi, Y, Mishiro-Sato, E, Liu, M.-C, Sakakibara, Y, Suiko, M, Kimura, M, Kakuta, Y.
登録日2010-10-09
公開日2011-10-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.
Nat Commun, 4, 2013
5X52
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Human serum albumin complexed with octanoate and N-acetyl-L-methionine
分子名称: N-ACETYLMETHIONINE, OCTANOIC ACID (CAPRYLIC ACID), PHOSPHATE ION, ...
著者Kawai, A, Otagiri, M.
登録日2017-02-14
公開日2017-05-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.005 Å)
主引用文献Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions
Biochim. Biophys. Acta, 1865, 2017
6UJU
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Structure of the HIV-1 gp41 transmembrane domain and cytoplasmic tail (LLP2)
分子名称: Envelope glycoprotein GP41
著者Piai, A, Fu, Q, Cai, Y, Ghantous, F, Xiao, T, Shaik, M.M, Peng, H, Rits-Volloch, S, Liu, Z, Chen, W, Seaman, M.S, Chen, B, Chou, J.J.
登録日2019-10-03
公開日2020-05-13
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein.
Nat Commun, 11, 2020
4O4R
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Murine Norovirus RdRp in complex with PPNDS
分子名称: 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, RNA-dependent-RNA-polymerase, SULFATE ION
著者Croci, R, Tarantino, D, Milani, M, Pezzullo, M, Bolognesi, M, Mastrangelo, E.
登録日2013-12-19
公開日2014-11-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.
Febs Lett., 588, 2014
5XSO
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Crystal structure of full-length FixJ from B. japonicum crystallized in space group C2221
分子名称: FORMIC ACID, GLYCEROL, Response regulator FixJ
著者Nishizono, Y, Hisano, T, Sawai, H, Shiro, Y, Nakamura, H, Wright, G.S.A, Saeki, A, Hikima, T, Yamamoto, M, Antonyuk, S.V, Hasnain, S.S.
登録日2017-06-14
公開日2018-05-23
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.778 Å)
主引用文献Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system.
Sci Signal, 11, 2018
3AP1
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Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide
分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, C4 peptide, GLYCEROL, ...
著者Teramoto, T, Fujikawa, Y, Kawaguchi, Y, Kurogi, K, Soejima, M, Adachi, R, Nakanishi, Y, Mishiro-Sato, E, Liu, M.-C, Sakakibara, Y, Suiko, M, Kimura, M, Kakuta, Y.
登録日2010-10-09
公開日2011-10-26
最終更新日2013-03-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.
Nat Commun, 4, 2013

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