4B7Q
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![BU of 4b7q by Molmil](/molmil-images/mine/4b7q) | H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE, ... | 著者 | Liu, J, van der Vries, E, Vachieri, S.G, Xiong, X, Collins, P.J, Walker, P.A, Haire, L.F, Hay, A.J, Schutten, M, Osterhaus, A.D.M.E, Martin, S.R, Boucher, C.A.B, Skehel, J.J, Gamblin, S.J. | 登録日 | 2012-08-21 | 公開日 | 2012-10-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.728 Å) | 主引用文献 | H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis Plos Pathog., 8, 2012
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4BAA
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![BU of 4baa by Molmil](/molmil-images/mine/4baa) | Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase | 分子名称: | PHENYLALANINE AMMONIA-LYASE | 著者 | Bartsch, S, Wybenga, G.G, Jansen, M, Heberling, M.M, Wu, B, Dijkstra, B.W, Janssen, D.B. | 登録日 | 2012-09-12 | 公開日 | 2013-01-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase To be Published
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4B3Q
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![BU of 4b3q by Molmil](/molmil-images/mine/4b3q) | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface | 分子名称: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, P51 RT, PRIMER DNA, ... | 著者 | Lapkouski, M, Tian, L, Miller, J.T, Le Grice, S.F.J, Yang, W. | 登録日 | 2012-07-25 | 公開日 | 2013-01-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (5 Å) | 主引用文献 | Complexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation Nat.Struct.Mol.Biol., 20, 2013
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4B63
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![BU of 4b63 by Molmil](/molmil-images/mine/4b63) | A. fumigatus ornithine hydroxylase (SidA) bound to NADP and ornithine | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, L-ORNITHINE N5 MONOOXYGENASE, ... | 著者 | Franceschini, S, Fedkenheuer, M, Vogelaar, N.J, Robinson, H.H, Sobrado, P, Mattevi, A. | 登録日 | 2012-08-09 | 公開日 | 2012-10-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Insight Into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases. Biochemistry, 51, 2012
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4YUJ
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![BU of 4yuj by Molmil](/molmil-images/mine/4yuj) | Multiconformer synchrotron model of CypA at 240 K | 分子名称: | Peptidyl-prolyl cis-trans isomerase A | 著者 | Keedy, D.A, Kenner, L.R, Warkentin, M, Woldeyes, R.A, Thompson, M.C, Brewster, A.S, Van Benschoten, A.H, Baxter, E.L, Hopkins, J.B, Uervirojnangkoorn, M, McPhillips, S.E, Song, J, Mori, R.A, Holton, J.M, Weis, W.I, Brunger, A.T, Soltis, M, Lemke, H, Gonzalez, A, Sauter, N.K, Cohen, A.E, van den Bedem, H, Thorne, R.E, Fraser, J.S. | 登録日 | 2015-03-18 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography. Elife, 4, 2015
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4B49
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![BU of 4b49 by Molmil](/molmil-images/mine/4b49) | 1.15 A Structure of Lysozyme Crystallized without 2-methyl-2,4- pentanediol | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, LYSOZYME C | 著者 | Jakoncic, J, Berger, J, Stauber, M, Axelbaum, A, Asherie, N. | 登録日 | 2012-07-28 | 公開日 | 2012-08-22 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Crystallization of Lysozyme with (R)-, (S)- and (Rs)-2-Methyl-2,4-Pentanediol Acta Crystallogr.,Sect.D, 71, 2015
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4DUH
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![BU of 4duh by Molmil](/molmil-images/mine/4duh) | Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor | 分子名称: | 4-{[4'-methyl-2'-(propanoylamino)-4,5'-bi-1,3-thiazol-2-yl]amino}benzoic acid, DNA gyrase subunit B | 著者 | Brvar, M, Renko, M, Perdih, A, Solmajer, T, Turk, D. | 登録日 | 2012-02-22 | 公開日 | 2012-08-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors. J.Med.Chem., 55, 2012
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4B24
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![BU of 4b24 by Molmil](/molmil-images/mine/4b24) | Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2 | 分子名称: | 5'-D(*CP*GP*AP*TP*AP*GP*GP*TP*AP*GP)-3', 5'-D(*GP*CP*TP*AP*CP*3DRP*TP*AP*TP*CP*GP)-3', PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2 | 著者 | Dalhus, B, Nilsen, L, Korvald, H, Huffman, J, Forstrom, R.J, McMurray, C.T, Alseth, I, Tainer, J.A, Bjoras, M. | 登録日 | 2012-07-12 | 公開日 | 2013-01-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Sculpting of DNA at Abasic Sites by DNA Glycosylase Homolog Mag2. Structure, 21, 2013
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2PWQ
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![BU of 2pwq by Molmil](/molmil-images/mine/2pwq) | Crystal structure of a putative ubiquitin conjugating enzyme from Plasmodium yoelii | 分子名称: | Ubiquitin conjugating enzyme | 著者 | Qiu, W, Dong, A, Hassanali, A, Lin, L, Brokx, S, Altamentova, S, Hills, T, Lew, J, Ravichandran, M, Kozieradzki, I, Zhao, Y, Schapira, M, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) | 登録日 | 2007-05-11 | 公開日 | 2007-05-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of a putative ubiquitin conjugating enzyme from Plasmodium yoelii. To be Published
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2IYF
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![BU of 2iyf by Molmil](/molmil-images/mine/2iyf) | The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering | 分子名称: | ERYTHROMYCIN A, MAGNESIUM ION, OLEANDOMYCIN GLYCOSYLTRANSFERASE, ... | 著者 | Bolam, D.N, Roberts, S.M, Proctor, M.R, Turkenburg, J.P, Dodson, E.J, Martinez-Fleites, C, Yang, M, Davis, B.G, Davies, G.J, Gilbert, H.J. | 登録日 | 2006-07-17 | 公開日 | 2007-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity. Proc.Natl.Acad.Sci.USA, 104, 2007
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2J6K
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![BU of 2j6k by Molmil](/molmil-images/mine/2j6k) | N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG) | 分子名称: | CD2-ASSOCIATED PROTEIN, SODIUM ION | 著者 | Moncalian, G, Cardenes, N, Deribe, Y.L, Spinola-Amilibia, M, Dikic, I, Bravo, J. | 登録日 | 2006-09-29 | 公開日 | 2006-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Atypical Polyproline Recognition by the Cms N- Terminal SH3 Domain. J.Biol.Chem., 281, 2006
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4ASD
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![BU of 4asd by Molmil](/molmil-images/mine/4asd) | Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with SORAFENIB (BAY 43-9006) | 分子名称: | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | 著者 | McTigue, M, Deng, Y, Ryan, K, Brooun, A, Diehl, W, Stewart, A. | 登録日 | 2012-04-30 | 公開日 | 2012-09-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109, 2012
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2IW1
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![BU of 2iw1 by Molmil](/molmil-images/mine/2iw1) | Crystal Structure of WaaG, a glycosyltransferase involved in lipopolysaccharide biosynthesis | 分子名称: | LIPOPOLYSACCHARIDE CORE BIOSYNTHESIS PROTEIN RFAG, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE | 著者 | Martinez-Fleites, C, Proctor, M, Roberts, S, Bolam, D.N, Gilbert, H.J, Davies, G.J. | 登録日 | 2006-06-23 | 公開日 | 2006-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4 Chem.Biol., 13, 2006
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8BIN
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![BU of 8bin by Molmil](/molmil-images/mine/8bin) | Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MR21 | 分子名称: | 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, Ephrin type-A receptor 2 | 著者 | Zhubi, R, Rak, M, Knapp, S, Kraemer, A, Structural Genomics Consortium (SGC) | 登録日 | 2022-11-02 | 公開日 | 2022-11-23 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. J.Med.Chem., 67, 2024
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2IXO
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![BU of 2ixo by Molmil](/molmil-images/mine/2ixo) | CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa1 PTPA1 | 分子名称: | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1 | 著者 | Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J. | 登録日 | 2006-07-09 | 公開日 | 2006-07-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity. Mol.Cell, 23, 2006
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2IXZ
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![BU of 2ixz by Molmil](/molmil-images/mine/2ixz) | Solution structure of the apical stem-loop of the human hepatitis B virus encapsidation signal | 分子名称: | 5'-R(*GP*CP*UP*GP*UP*GP*CP*CP)-3' | 著者 | Flodell, S, Petersen, M, Girard, F, Zdunek, J, Kidd-Ljunggren, K, Schleucher, J, Wijmenga, S.S. | 登録日 | 2006-07-11 | 公開日 | 2006-09-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the apical stem-loop of the human hepatitis B virus encapsidation signal. Nucleic Acids Res., 34, 2006
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2PJ8
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2PJA
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4B2D
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![BU of 4b2d by Molmil](/molmil-images/mine/4b2d) | human PKM2 with L-serine and FBP bound. | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PYRUVATE KINASE ISOZYMES M1/M2, ... | 著者 | Chaneton, B, Hillmann, P, Zheng, L, Martin, A.C.L, Maddocks, O.D.K, Chokkathukalam, A, Coyle, J.E, Jankevics, A, Holding, F.P, Vousden, K.H, Frezza, C, O'Reilly, M, Gottlieb, E. | 登録日 | 2012-07-13 | 公開日 | 2012-10-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature, 491, 2012
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8BIO
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![BU of 8bio by Molmil](/molmil-images/mine/8bio) | Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MRAL5 | 分子名称: | 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-[2-chloranyl-5-(trifluoromethyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, Ephrin type-A receptor 2 | 著者 | Zhubi, R, Rak, M, Lucic, A, Knapp, S, Kraemer, A, Structural Genomics Consortium (SGC) | 登録日 | 2022-11-02 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. Eur.J.Med.Chem., 254, 2023
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4AZ0
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![BU of 4az0 by Molmil](/molmil-images/mine/4az0) | crystal structure of cathepsin a, complexed with 8a. | 分子名称: | (S)-3-{[1-(2-Fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | 著者 | Ruf, S, Buning, C, Schreuder, H, Horstick, G, Linz, W, Olpp, T, Pernerstorfer, J, Hiss, K, Kroll, K, Kannt, A, Kohlmann, M, Linz, D, Huebschle, T, Ruetten, H, Wirth, K, Schmidt, T, Sadowski, T. | 登録日 | 2012-06-22 | 公開日 | 2012-09-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Novel Beta-Amino Acid Derivatives as Inhibitors of Cathepsin A. J.Med.Chem., 55, 2012
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2PJ3
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2JNA
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![BU of 2jna by Molmil](/molmil-images/mine/2jna) | Solution NMR Structure of Salmonella typhimurium LT2 Secreted Protein STM0082: Northeast Structural Genomics Consortium Target StR109 | 分子名称: | Putative secreted protein | 著者 | Eletsky, A, Parish, D, Liu, G, Sukumaran, D, Jiang, M, Cunningham, K, Ma, L, Xiao, R, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-12-31 | 公開日 | 2007-02-06 | 最終更新日 | 2023-12-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of Salmonella typhimurium LT2 Secreted Protein STM0082: Northeast Structural Genomics Consortium Target StR109 To be Published
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2JA2
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![BU of 2ja2 by Molmil](/molmil-images/mine/2ja2) | Mycobacterium tuberculosis glutamyl-tRNA synthetase | 分子名称: | ACETATE ION, CHLORIDE ION, GLUTAMYL-TRNA SYNTHETASE | 著者 | Bourenkov, G.P, Strizhov, N, Shkolnaya, L.A, Bruning, M, Bartunik, H.D. | 登録日 | 2006-11-20 | 公開日 | 2008-10-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Basis for Discriminating or Non-Discriminating Functioning of Glutamyl-tRNA Synthetases To be Published
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4AUW
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![BU of 4auw by Molmil](/molmil-images/mine/4auw) | CRYSTAL STRUCTURE OF THE BZIP HOMODIMERIC MAFB IN COMPLEX WITH THE C- MARE BINDING SITE | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, C-MARE BINDING SITE (5'-D(*AP*TP*AP*AP*TP*GP*CP*TP* GP*AP*CP*GP*TP*CP*AP*GP*CP*AP*AP*TP*T)-3'), MERCURY (II) ION, ... | 著者 | Textor, L.C, Holton, S, Wilmanns, M. | 登録日 | 2012-05-22 | 公開日 | 2013-06-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Expression, purification, crystallization and preliminary crystallographic analysis of the mouse transcription factor MafB in complex with its DNA-recognition motif Cmare Acta Crystallogr Sect F Struct Biol Cryst Commun., 63, 2007
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