4AZ0
crystal structure of cathepsin a, complexed with 8a.
Summary for 4AZ0
Entry DOI | 10.2210/pdb4az0/pdb |
Related | 1IVY 4AZ3 |
Descriptor | LYSOSOMAL PROTECTIVE PROTEIN 32 KDA CHAIN, LYSOSOMAL PROTECTIVE PROTEIN 20 KDA CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | hydrolase, drug discovery, cardiovascular drug |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 53754.11 |
Authors | Ruf, S.,Buning, C.,Schreuder, H.,Horstick, G.,Linz, W.,Olpp, T.,Pernerstorfer, J.,Hiss, K.,Kroll, K.,Kannt, A.,Kohlmann, M.,Linz, D.,Huebschle, T.,Ruetten, H.,Wirth, K.,Schmidt, T.,Sadowski, T. (deposition date: 2012-06-22, release date: 2012-09-26, Last modification date: 2023-12-20) |
Primary citation | Ruf, S.,Buning, C.,Schreuder, H.,Horstick, G.,Linz, W.,Olpp, T.,Pernerstorfer, J.,Hiss, K.,Kroll, K.,Kannt, A.,Kohlmann, M.,Linz, D.,Hubschle, T.,Rutten, H.,Wirth, K.,Schmidt, T.,Sadowski, T. Novel Beta-Amino Acid Derivatives as Inhibitors of Cathepsin A. J.Med.Chem., 55:7636-, 2012 Cited by PubMed: 22861813DOI: 10.1021/JM300663N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)