4AZ0

crystal structure of cathepsin a, complexed with 8a.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	LYSOSOMAL PROTECTIVE PROTEIN 32 KDA CHAIN	polymer	300	33773.7	1	UniProt (P10619) Pfam (PF00450) In PDB	HOMO SAPIENS (HUMAN)	CARBOXYPEPTIDASE C, CARBOXYPEPTIDASE L, CATHEPSIN A, PROTECTIVE PROTEIN CATHEPSIN A, PPCA, PROTECTIVE PROTEIN FOR BETA-GALACTOSIDASE
2	B	LYSOSOMAL PROTECTIVE PROTEIN 20 KDA CHAIN	polymer	155	18073.7	1	UniProt (P10619) Pfam (PF00450) In PDB	HOMO SAPIENS (HUMAN)	CARBOXYPEPTIDASE C, CARBOXYPEPTIDASE L, CATHEPSIN A, PROTECTIVE PROTEIN CATHEPSIN A, PPCA, PROTECTIVE PROTEIN FOR BETA-GALACTOSIDASE
3	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	A	(S)-3-{[1-(2-Fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid	non-polymer		383.4	1	Chemie (S61)
5	A, B	CADMIUM ION	non-polymer		112.4	6	Chemie (CD)
6		water	water		18.0	308	Chemie (HOH)

Sequence modifications

A: 1 - 298 (UniProt: P10619)

PDB	External Database	Details
Ser -1	-	expression tag
Arg 0	-	expression tag

B: 299 - 452 (UniProt: P10619)

PDB	External Database	Details
Glu 453	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51847.5
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	7
	Total formula weight	1057.8
All*	Total formula weight	53754.1

*Water molecules are not included.