6IY3
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![BU of 6iy3 by Molmil](/molmil-images/mine/6iy3) | Structure of Snf2-MMTV-A nucleosome complex at shl-2 in ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (147-MER), Histone H2A, ... | Authors: | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | Deposit date: | 2018-12-12 | Release date: | 2019-04-03 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567, 2019
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2MKM
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![BU of 2mkm by Molmil](/molmil-images/mine/2mkm) | G-triplex structure and formation propensity | Descriptor: | DNA_(5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*G)-3') | Authors: | Cerofolini, L, Fragai, M, Giachetti, A, Limongelli, V, Luchinat, C, Novellino, E, Parrinello, M, Randazzo, A. | Deposit date: | 2014-02-10 | Release date: | 2014-11-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | G-triplex structure and formation propensity. Nucleic Acids Res., 42, 2014
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6AQF
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![BU of 6aqf by Molmil](/molmil-images/mine/6aqf) | Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | Authors: | Eddy, M.T, Lee, M.Y, Gao, Z, White, K, Didenko, T, Horst, R, Audet, M, Stanczak, P, McClary, K.M, Han, G.W, Jacobson, K.A, Stevens, R.C, Wuthrich, K. | Deposit date: | 2017-08-19 | Release date: | 2018-01-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor. Cell, 172, 2018
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6AQV
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![BU of 6aqv by Molmil](/molmil-images/mine/6aqv) | Crystal Structure of Z-DNA with 6-fold Twinning_Z3B | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*CP*G)-3') | Authors: | Luo, Z, Dauter, Z, Gilski, M. | Deposit date: | 2017-08-21 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Four highly pseudosymmetric and/or twinned structures of d(CGCGCG)2 extend the repertoire of crystal structures of Z-DNA. Acta Crystallogr D Struct Biol, 73, 2017
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7YXF
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![BU of 7yxf by Molmil](/molmil-images/mine/7yxf) | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | Descriptor: | 1-(2-piperazin-1-ylethyl)-5-pyridin-4-yl-indole, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... | Authors: | Snee, M, Katariya, M, Levy, C, Leys, D. | Deposit date: | 2022-02-16 | Release date: | 2023-03-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. Chemistry, 29, 2023
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6ARU
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![BU of 6aru by Molmil](/molmil-images/mine/6aru) | Structure of Cetuximab Fab mutant in complex with EGFR extracellular domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab mutant heavy chain Fab fragment,Immunoglobulin gamma-1 heavy chain, ... | Authors: | Christie, M, Christ, D. | Deposit date: | 2017-08-23 | Release date: | 2018-08-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of Cetuximab Fab mutant in complex with EGFR extracellular domain To Be Published
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3NTT
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![BU of 3ntt by Molmil](/molmil-images/mine/3ntt) | Structural insights of Adeno-Associated virus 5. A gene therapy Vector for Cystic Fibrosis | Descriptor: | Capsid protein, GLYCEROL, SODIUM ION | Authors: | Govindasamy, L, DiMattia, M, Chiorini, J.A, McKenna, R, Muzyczka, N, Agbandje-McKenna, M. | Deposit date: | 2010-07-05 | Release date: | 2011-12-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural insights into adeno-associated virus serotype 5. J.Virol., 87, 2013
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6AWX
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![BU of 6awx by Molmil](/molmil-images/mine/6awx) | Structure of PR-10 Allergen Ara h 8.01. | Descriptor: | Ara h 8 allergen, SODIUM ION | Authors: | Offermann, L.R, Yarbrough, J, McBride, J, Hurlburt, B.K, Maleki, S.J, Pote, S.S, Chruszcz, M. | Deposit date: | 2017-09-06 | Release date: | 2018-09-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of PR-10 Allergen Ara h 8.01. To Be Published
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2MJC
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![BU of 2mjc by Molmil](/molmil-images/mine/2mjc) | Zn-binding domain of eukaryotic translation initiation factor 3, subunit G | Descriptor: | Eukaryotic translation initiation factor 3 subunit G, ZINC ION | Authors: | Al-Abdul-Wahid, M, Menade, M, Xie, J, Kozlov, G, Gehring, K. | Deposit date: | 2014-01-03 | Release date: | 2015-01-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the Zn-binding domain of eukaryotic translation initiation factor 3, subunit G To be Published
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6AXZ
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![BU of 6axz by Molmil](/molmil-images/mine/6axz) | |
5F0C
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![BU of 5f0c by Molmil](/molmil-images/mine/5f0c) | Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 4 at 1.87A resolution | Descriptor: | 3-cyclopentyl-~{N}-(3-piperidin-1-ylphenyl)propanamide, HTH-type transcriptional regulator EthR, SULFATE ION | Authors: | Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. | Deposit date: | 2015-11-27 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016
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6AYG
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![BU of 6ayg by Molmil](/molmil-images/mine/6ayg) | Human Apo-TRPML3 channel at pH 4.8 | Descriptor: | Mucolipin-3 | Authors: | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | Deposit date: | 2017-09-08 | Release date: | 2017-11-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.65 Å) | Cite: | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat. Struct. Mol. Biol., 24, 2017
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4M3S
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![BU of 4m3s by Molmil](/molmil-images/mine/4m3s) | Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with HEPES | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, SULFATE ION, ... | Authors: | Majorek, K.A, Chruszcz, M, Xu, X, Cymborowski, M, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2013-08-06 | Release date: | 2013-08-21 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments. Protein Sci., 23, 2014
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1X3F
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![BU of 1x3f by Molmil](/molmil-images/mine/1x3f) | Crystal structure of the single-stranded DNA-binding protein from Mycobacterium SMEGMATIS | Descriptor: | CADMIUM ION, Single-strand binding protein | Authors: | Saikrishnan, K, Manjunath, G.P, Singh, P, Jeyakanthan, J, Dauter, Z, Sekar, K, Muniyappa, K, Vijayan, M. | Deposit date: | 2005-05-05 | Release date: | 2005-08-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association. Acta Crystallogr.,Sect.D, 61, 2005
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5OHE
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![BU of 5ohe by Molmil](/molmil-images/mine/5ohe) | Globin sensor domain of AfGcHK (FeIII form) in complex with cyanide | Descriptor: | CHLORIDE ION, CYANIDE ION, Globin-coupled histidine kinase, ... | Authors: | Skalova, T, Kolenko, P, Dohnalek, J, Stranava, M, Martinkova, M. | Deposit date: | 2017-07-16 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction. J. Biol. Chem., 292, 2017
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6B4Q
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![BU of 6b4q by Molmil](/molmil-images/mine/6b4q) | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with pyridin-4-ol | Descriptor: | DIMETHYL SULFOXIDE, Purine nucleoside phosphorylase, pyridin-4-ol | Authors: | Faheem, M, Neto, J.B, Collins, P, Pearce, N.M, Valadares, N.F, Bird, L, Pereira, H.M, Delft, F.V, Barbosa, J.A.R.G. | Deposit date: | 2017-09-27 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with pyridine-4-ol To Be Published
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3O2D
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![BU of 3o2d by Molmil](/molmil-images/mine/3o2d) | Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody | Descriptor: | T-cell surface glycoprotein CD4, ibalizumab heavy chain, ibalizumab light chain | Authors: | Freeman, M.M, Seaman, M.S, Rits-Volloch, S, Hong, X, Ho, D.D, Chen, B. | Deposit date: | 2010-07-22 | Release date: | 2010-12-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Crystal Structure of HIV-1 Primary Receptor CD4 in Complex with a Potent Antiviral Antibody. Structure, 18, 2010
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6B5Z
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![BU of 6b5z by Molmil](/molmil-images/mine/6b5z) | IMPase (AF2372) with 25 mM Asp | Descriptor: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, ASPARTIC ACID, Fructose-1,6-bisphosphatase/inositol-1-monophosphatase, ... | Authors: | Goldstein, R.I, Roberts, M. | Deposit date: | 2017-10-01 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Osmolyte binding capacity of a dual action IMPase/FBPase (AF2372) To Be Published
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6J7W
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![BU of 6j7w by Molmil](/molmil-images/mine/6j7w) | Crystal Structure of Human BCMA in complex with UniAb(TM) VH | Descriptor: | Tumor necrosis factor receptor superfamily member 17, UniAb | Authors: | Clarke, S.C, Ma, B, Trinklein, N.D, Schellenberger, U, Osborn, M, Ouisse, L, Boudreau, A, Davison, L, Harris, K.E, Ugamraj, H, Balasubramani, A, Dang, K, Jorgensen, B, Ogana, H, Pham, D, Pratap, P, Sankaran, P, Anegon, I, van Schooten, W, Bruggemann, M, Buelow, R, Force Aldred, S. | Deposit date: | 2019-01-18 | Release date: | 2019-02-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies Front Immunol, 9, 2018
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3O3P
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![BU of 3o3p by Molmil](/molmil-images/mine/3o3p) | Crystal structure of R. xylanophilus MpgS in complex with GDP-Mannose | Descriptor: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... | Authors: | Macedo-Ribeiro, S, Pereira, P.J.B, Empadinhas, N, da Costa, M.S. | Deposit date: | 2010-07-25 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.529 Å) | Cite: | Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity Mol.Microbiol., 79, 2011
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2M1X
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![BU of 2m1x by Molmil](/molmil-images/mine/2m1x) | TICAM-1 TIR domain structure | Descriptor: | TIR domain-containing adapter molecule 1 | Authors: | Enokizono, Y, Kumeta, H, Funami, K, Horiuchi, M, Sarmiento, J, Yamashita, K, Standley, D.M, Matsumoto, M, Seya, T, Inagaki, F. | Deposit date: | 2012-12-07 | Release date: | 2014-01-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. Proc.Natl.Acad.Sci.USA, 110, 2013
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7YUY
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![BU of 7yuy by Molmil](/molmil-images/mine/7yuy) | Structure of a mutated membrane-bound glycosyltransferase | Descriptor: | (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hu, X.L, Yang, P, Zhang, M, Liu, X.T, Yu, H.J. | Deposit date: | 2022-08-18 | Release date: | 2023-03-29 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1. Nature, 616, 2023
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2LWJ
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![BU of 2lwj by Molmil](/molmil-images/mine/2lwj) | |
6FAT
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![BU of 6fat by Molmil](/molmil-images/mine/6fat) | |
2MKO
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![BU of 2mko by Molmil](/molmil-images/mine/2mko) | G-triplex structure and formation propensity | Descriptor: | DNA_(5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*G)-3'), POTASSIUM ION | Authors: | Cerofolini, L, Fragai, M, Giachetti, A, Limongelli, V, Luchinat, C, Novellino, E, Parrinello, M, Randazzo, A. | Deposit date: | 2014-02-11 | Release date: | 2014-11-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | G-triplex structure and formation propensity. Nucleic Acids Res., 42, 2014
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