8B0I
| CryoEM structure of bacterial RapZ.GlmZ complex central to the control of cell envelope biogenesis | Descriptor: | GlmZ small regulatory RNA, RNase adapter protein RapZ | Authors: | Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F. | Deposit date: | 2022-09-07 | Release date: | 2022-10-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis. Embo J., 42, 2023
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8B0J
| CryoEM structure of bacterial RNaseE.RapZ.GlmZ complex central to the control of cell envelope biogenesis | Descriptor: | GlmZ small RNA, RNase adapter protein RapZ, Ribonuclease E | Authors: | Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F. | Deposit date: | 2022-09-07 | Release date: | 2022-10-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis. Embo J., 42, 2023
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4UOT
| Thermodynamic hyperstability in parametrically designed helical bundles | Descriptor: | DESIGNED HELICAL BUNDLE 5H2L | Authors: | Oberdorfer, G, Huang, P, Pei, X.Y, Xu, C, Gonen, T, Nannenga, B, DiMaio, D, Rogers, J, Luisi, B.F, Baker, D. | Deposit date: | 2014-06-09 | Release date: | 2014-11-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | High Thermodynamic Stability of Parametrically Designed Helical Bundles Science, 346, 2014
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8BVJ
| Hfq-Crc-estA translation repression complex | Descriptor: | Catabolite repression control protein, RNA-binding protein Hfq, estA mRNA | Authors: | Dendooven, T, Luisi, B.F. | Deposit date: | 2022-12-04 | Release date: | 2023-01-25 | Last modified: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Translational regulation by Hfq-Crc assemblies emerges from polymorphic ribonucleoprotein folding. Embo J., 42, 2023
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7PCH
| Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:2 complex | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, Iron-regulated surface determinant protein B, ... | Authors: | De Bei, O, Gianquinto, E, Chirgadze, D.Y, Hardwick, S.W, Spyrakis, F, Luisi, B.F, Campanini, B. | Deposit date: | 2021-08-03 | Release date: | 2022-04-13 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PCQ
| Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:1 complex | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, Iron-regulated surface determinant protein B, ... | Authors: | De Bei, O, Gianquinto, E, Chirgadze, D.Y, Hardwick, S.W, Spyrakis, F, Luisi, B.F, Campanini, B. | Deposit date: | 2021-08-03 | Release date: | 2022-04-13 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction. Proc.Natl.Acad.Sci.USA, 119, 2022
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4OXP
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7PCF
| Human methemoglobin bound to Staphylococcus aureus hemophore IsdB | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, Iron-regulated surface determinant protein B, ... | Authors: | De Bei, O, Gianquinto, E, Chirgadze, D.Y, Hardwick, S.W, Spyrakis, F, Luisi, B.F, Campanini, B. | Deposit date: | 2021-08-03 | Release date: | 2022-04-13 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (5.82 Å) | Cite: | Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction. Proc.Natl.Acad.Sci.USA, 119, 2022
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7P06
| Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in outward-facing conformation with ADP-orthovanadate/ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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7P05
| Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation with ADP/ATP and rhodamine 6G | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Pleiotropic ABC efflux transporter of multiple drugs, ... | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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7P04
| Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation with ADP/ATP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Pleiotropic ABC efflux transporter of multiple drugs | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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6HCK
| The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with dipeptide Leu-Leu | Descriptor: | LEUCINE, Listeriolysin regulatory protein, SODIUM ION | Authors: | Grundstrom, C, Oelker, M, Krypotou, E, Scortti, M, Luisi, B.F, Vazquez-Boland, J, Sauer-Eriksson, A.E. | Deposit date: | 2018-08-15 | Release date: | 2019-02-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Control of Bacterial Virulence through the Peptide Signature of the Habitat. Cell Rep, 26, 2019
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1IBE
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4RMO
| Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale | Descriptor: | CALCIUM ION, CptN Toxin, RNA (45-MER) | Authors: | Rao, F, Voss, J.E, Short, F.L, Luisi, B.F. | Deposit date: | 2014-10-21 | Release date: | 2015-09-30 | Last modified: | 2015-11-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein-RNA toxin-antitoxin system. Nucleic Acids Res., 43, 2015
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5A0T
| Catalysis and 5' end sensing by ribonuclease RNase J of the metallo- beta-lactamase family | Descriptor: | 5'-R(*CP*GP*CP*CP*UP)-3', DI(HYDROXYETHYL)ETHER, RIBONUCLEASE J, ... | Authors: | Pei, X.Y, Bralley, P, Jones, G.H, Luisi, B.F. | Deposit date: | 2015-04-22 | Release date: | 2015-08-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.283 Å) | Cite: | Linkage of Catalysis and 5' End Recognition in Ribonuclease Rnase J Nucleic Acids Res., 43, 2015
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6GWK
| The crystal structure of Hfq from Caulobacter crescentus | Descriptor: | RNA-binding protein Hfq | Authors: | Santiago-Frangos, A, Frohlich, K.S, Jeliazkov, J.R, Gray, J.R, Luisi, B.F, Woodson, S.A, Hardwick, S.W. | Deposit date: | 2018-06-25 | Release date: | 2019-05-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Caulobacter crescentusHfq structure reveals a conserved mechanism of RNA annealing regulation. Proc.Natl.Acad.Sci.USA, 116, 2019
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5A0V
| Catalysis and 5' end sensing by ribonuclease RNase J of the metallo- beta-lactamase family | Descriptor: | 5'-R(*CP*GP*CP*CP*UP*CP)-3', CYTIDINE-5'-MONOPHOSPHATE, RIBONUCLEASE J, ... | Authors: | Pei, X.Y, Bralley, P, Jones, G.H, Luisi, B.F. | Deposit date: | 2015-04-23 | Release date: | 2015-08-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Linkage of Catalysis and 5' End Recognition in Ribonuclease Rnase J Nucleic Acids Res., 43, 2015
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1LR0
| Pseudomonas aeruginosa TolA Domain III, Seleno-methionine Derivative | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, TolA protein, ZINC ION | Authors: | Witty, M, Sanz, C, Shah, A, Grossman, J.G, Mizuguchi, K, Perham, R.N, Luisi, B. | Deposit date: | 2002-05-14 | Release date: | 2002-05-29 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (1.914 Å) | Cite: | Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein. EMBO J., 21, 2002
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2XDD
| A processed non-coding RNA regulates a bacterial antiviral system | Descriptor: | TOXI, TOXN, ZINC ION | Authors: | Blower, T.R, Pei, X.Y, Short, F.L, Fineran, P.C, Humphreys, D.P, Luisi, B.F, Salmond, G.P.C. | Deposit date: | 2010-04-30 | Release date: | 2011-01-12 | Last modified: | 2015-09-16 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Phage Abortive Infection System, Toxin, Functions as a Protein-RNA Toxin-Antitoxin Pair. Proc.Natl.Acad.Sci.USA, 106, 2009
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6O1L
| Architectural principles for Hfq/Crc-mediated regulation of gene expression Hfq-Crc-amiE 2:3:2 complex | Descriptor: | Catabolite repression control protein, RNA (5'-R(*AP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3'), RNA-binding protein Hfq | Authors: | Pei, X.Y, Dendooven, T, Sonnleitner, E, Chen, S, Blasi, U, Luisi, B.F. | Deposit date: | 2019-02-20 | Release date: | 2019-03-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Architectural principles for Hfq/Crc-mediated regulation of gene expression. Elife, 8, 2019
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6O1K
| Architectural principles for Hfq/Crc-mediated regulation of gene expression. Hfq-Crc-amiE 2:2:2 complex (core complex) | Descriptor: | Catabolite repression control protein, RNA (5'-R(*AP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3'), RNA-binding protein Hfq | Authors: | Pei, X.Y, Dendooven, T, Sonnleitner, E, Chen, S, Blasi, U, Luisi, B.F. | Deposit date: | 2019-02-20 | Release date: | 2019-03-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Architectural principles for Hfq/Crc-mediated regulation of gene expression Elife, 8, 2019
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5AOH
| Crystal Structure of CarF | Descriptor: | POTASSIUM ION, Spore coat protein CotH | Authors: | Tichy, E.M, Hardwick, S.W, Luisi, B.F, C Salmond, G.P. | Deposit date: | 2015-09-10 | Release date: | 2017-01-25 | Last modified: | 2019-09-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 1.8 angstrom resolution crystal structure of the carbapenem intrinsic resistance protein CarF. Acta Crystallogr D Struct Biol, 73, 2017
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6O1M
| Architectural principles for Hfq/Crc-mediated regulation of gene expression. Hfq-Crc-amiE 2:4:2 complex | Descriptor: | Catabolite repression control protein, RNA (5'-R(*AP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3'), RNA-binding protein Hfq | Authors: | Pei, X.Y, Dendooven, T, Sonnleitner, E, Chen, S, Blasi, U, Luisi, B.F. | Deposit date: | 2019-02-20 | Release date: | 2019-03-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Architectural principles for Hfq/Crc-mediated regulation of gene expression. Elife, 8, 2019
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3GCM
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5V5S
| multi-drug efflux; membrane transport; RND superfamily; Drug resistance | Descriptor: | Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, Outer membrane protein TolC | Authors: | wang, Z, fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-15 | Release date: | 2017-04-19 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
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