5ZDS
| Crystal structure of the second PDZ domain of Frmpd2 | Descriptor: | FERM and PDZ domain-containing 2 | Authors: | Lu, X, Wang, X.F. | Deposit date: | 2018-02-24 | Release date: | 2019-02-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors. Biochem.Biophys.Res.Commun., 516, 2019
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6UYI
| hRpn13:hRpn2:K48-diubiquitin | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | Authors: | Lu, X, Walters, K.J. | Deposit date: | 2019-11-13 | Release date: | 2020-03-11 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure. Structure, 28, 2020
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4PFU
| Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution | Descriptor: | ABC transporter substrate-binding protein, MAGNESIUM ION, SULFATE ION, ... | Authors: | Lu, X, Ghimire-Rijal, S, Cuneo, M.J. | Deposit date: | 2014-04-30 | Release date: | 2014-09-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Duplication of Genes in an ATP-binding Cassette Transport System Increases Dynamic Range While Maintaining Ligand Specificity. J.Biol.Chem., 289, 2014
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6CO4
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6UYJ
| hRpn13:hRpn2:K48-diubiquitin | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | Authors: | Lu, X, Walters, K.J. | Deposit date: | 2019-11-13 | Release date: | 2020-03-11 | Last modified: | 2020-05-20 | Method: | SOLUTION NMR | Cite: | An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure. Structure, 28, 2020
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4PFY
| Crystal structure of mannohexaose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1223) from THERMOTOGA MARITIMA at 1.5 A resolution | Descriptor: | ABC transporter substrate-binding protein, MAGNESIUM ION, NITRATE ION, ... | Authors: | Lu, X, Ghimire-Rijal, S, Cuneo, M.J. | Deposit date: | 2014-05-01 | Release date: | 2014-09-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Duplication of Genes in an ATP-binding Cassette Transport System Increases Dynamic Range While Maintaining Ligand Specificity. J.Biol.Chem., 289, 2014
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4PFT
| Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1223) from THERMOTOGA MARITIMA at 1.75 A resolution | Descriptor: | ABC transporter substrate-binding protein, MAGNESIUM ION, NITRATE ION, ... | Authors: | Lu, X, Ghimire-Rijal, S, Cuneo, M.J. | Deposit date: | 2014-04-30 | Release date: | 2014-09-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.747 Å) | Cite: | Duplication of Genes in an ATP-binding Cassette Transport System Increases Dynamic Range While Maintaining Ligand Specificity. J.Biol.Chem., 289, 2014
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4PFW
| Crystal structure of mannohexaose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.2 A resolution | Descriptor: | ABC transporter substrate-binding protein, GLYCEROL, MAGNESIUM ION, ... | Authors: | Lu, X, Ghimire-Rijal, S, Cuneo, M.J. | Deposit date: | 2014-04-30 | Release date: | 2014-09-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | Duplication of Genes in an ATP-binding Cassette Transport System Increases Dynamic Range While Maintaining Ligand Specificity. J.Biol.Chem., 289, 2014
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4KDO
| Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus in complex with human receptor analog LSTc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | Deposit date: | 2013-04-25 | Release date: | 2013-07-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.396 Å) | Cite: | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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4KPS
| Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, ... | Authors: | Lu, X, Qi, J, Shi, Y, Gao, G. | Deposit date: | 2013-05-14 | Release date: | 2013-07-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.587 Å) | Cite: | Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6 J.Virol., 87, 2013
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4KDN
| Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus in complex with avian receptor analog LSTa | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | Deposit date: | 2013-04-25 | Release date: | 2013-07-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.483 Å) | Cite: | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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4KDQ
| Crystal structure of the hemagglutinin of A/Xinjiang/1/2006 virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | Authors: | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | Deposit date: | 2013-04-25 | Release date: | 2013-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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4KDM
| Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | Authors: | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | Deposit date: | 2013-04-25 | Release date: | 2013-07-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.496 Å) | Cite: | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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4KPQ
| Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | Authors: | Lu, X, Qi, J, Shi, Y, Gao, G. | Deposit date: | 2013-05-14 | Release date: | 2013-07-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6 J.Virol., 87, 2013
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8HD3
| Farnesoid X Receptor Agonists_FXR fused with a HD3 peptide | Descriptor: | Farnesoid X Receptor, [(3s,5s,7s)-adamantan-1-yl][4-(2-amino-5-chlorophenyl)piperazin-1-yl]methanone | Authors: | Lu, X, Zhang, H. | Deposit date: | 2022-11-03 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystal structure of FXR fused with a HD3 peptide in complex with agonist QT0127 To Be Published
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5HM4
| Crystal structure of oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.0 A resolution | Descriptor: | CALCIUM ION, Mannoside ABC transport system, sugar-binding protein | Authors: | Lu, X, Ghimire-Rijal, S, Myles, D.A.A, Cuneo, M.J. | Deposit date: | 2016-01-15 | Release date: | 2016-11-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Periplasmic Binding Protein Dimer Has a Second Allosteric Event Tied to Ligand Binding. Biochemistry, 56, 2017
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5JYY
| Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-[(2-methoxyethyl)carbamoyl]-D-glycero-D-galacto-non-2-enon ic acid, CALCIUM ION, ... | Authors: | Fu, L, Wu, Y, Bi, Y, Zhang, S, Lv, X, Qi, J, Li, Y, Lu, X, Yan, J, Gao, G.F, Li, X. | Deposit date: | 2016-05-15 | Release date: | 2016-06-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses J.Med.Chem., 59, 2016
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4RC6
| Crystal structure of cyanobacterial aldehyde-deformylating oxygenase 122F mutant | Descriptor: | Aldehyde decarbonylase, FE (II) ION | Authors: | Jia, C.J, Li, M, Li, J.J, Zhang, J.J, Zhang, H.M, Cao, P, Pan, X.W, Lu, X.F, Chang, W.R. | Deposit date: | 2014-09-14 | Release date: | 2014-12-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases. Protein Cell, 6, 2015
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6RZ3
| Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP | Descriptor: | Cellular tumor antigen p53, RelA-associated inhibitor, ZINC ION | Authors: | Chen, S, Ren, J, Jones, E.Y, Lu, X. | Deposit date: | 2019-06-12 | Release date: | 2019-10-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (4.23 Å) | Cite: | iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition. Proc.Natl.Acad.Sci.USA, 116, 2019
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1BL4
| FKBP MUTANT F36V COMPLEXED WITH REMODELED SYNTHETIC LIGAND | Descriptor: | PROTEIN (FK506 BINDING PROTEIN), {3-[3-(3,4-DIMETHOXY-PHENYL)-1-(1-{1-[2-(3,4,5-TRIMETHOXY-PHENYL)-BUTYRYL]-PIPERIDIN-2YL}-VINYLOXY)-PROPYL]-PHENOXY}-ACETIC ACID | Authors: | Hatada, M.H, Clackson, T, Yang, W, Rozamus, L.W, Amara, J, Rollins, C.T, Stevenson, L.F, Magari, S.R, Wood, S.A, Courage, N.L, Lu, X, Cerasoli Junior, F, Gilman, M, Holt, D. | Deposit date: | 1998-07-23 | Release date: | 1998-09-02 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.USA, 95, 1998
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5MV2
| Crystal structure of the E protein of the Japanese encephalitis live attenuated vaccine virus | Descriptor: | E protein | Authors: | Liu, X, Zhao, X, Na, R, Li, L, Warkentin, E, Witt, J, Lu, X, Wei, Y, Peng, G, Li, Y, Wang, J. | Deposit date: | 2017-01-14 | Release date: | 2018-05-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism. Protein Cell, 10, 2019
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5MV1
| Crystal structure of the E protein of the Japanese encephalitis virulent virus | Descriptor: | E protein | Authors: | Liu, X, Zhao, X, Na, R, Li, L, Warkentin, E, Witt, J, Lu, X, Wei, Y, Peng, G, Li, Y, Wang, J. | Deposit date: | 2017-01-14 | Release date: | 2018-05-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism. Protein Cell, 10, 2019
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5OPC
| Factor Inhibiting HIF (FIH) in complex with zinc and Vadadustat | Descriptor: | GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... | Authors: | Leissing, T.M, Schofield, C.J, Clifton, I.J, Lu, X, Zhang, D. | Deposit date: | 2017-08-09 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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5OP8
| Factor Inhibiting HIF (FIH) in complex with zinc and Molidustat | Descriptor: | 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)-1~{H}-pyrazol-3-one, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | Authors: | Leissing, T.M, Schofield, C.J, Clifton, I.J, Lu, X. | Deposit date: | 2017-08-09 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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4Y25
| Bacterial polysaccharide outer membrane secretin | Descriptor: | Poly-beta-1,6-N-acetyl-D-glucosamine export protein | Authors: | Wang, Y, AndolePannuri, A, Ni, D, Zhou, H, Cao, X, Lu, X, Romeo, T, Huang, Y. | Deposit date: | 2015-02-09 | Release date: | 2016-03-16 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (2.821 Å) | Cite: | Structural Basis for Translocation of a Biofilm-supporting Exopolysaccharide across the Bacterial Outer Membrane J.Biol.Chem., 291, 2016
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