5OP8

Factor Inhibiting HIF (FIH) in complex with zinc and Molidustat

Summary for 5OP8

Entry DOI	10.2210/pdb5op8/pdb
Descriptor	Hypoxia-inducible factor 1-alpha inhibitor, ZINC ION, 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)-1~{H}-pyrazol-3-one, ... (6 entities in total)
Functional Keywords	on-heme, dioxygenase, oxygenase, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, epigenetic regulation, signaling, ard, beta-hydroxylation, activator-inhibitor, oxidoreductase-peptide complex, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: Q9NWT6
Total number of polymer chains	1
Total formula weight	41267.44
Authors	Leissing, T.M.,Schofield, C.J.,Clifton, I.J.,Lu, X. (deposition date: 2017-08-09, release date: 2017-10-18, Last modification date: 2024-01-17)
Primary citation	Yeh, T.L.,Leissing, T.M.,Abboud, M.I.,Thinnes, C.C.,Atasoylu, O.,Holt-Martyn, J.P.,Zhang, D.,Tumber, A.,Lippl, K.,Lohans, C.T.,Leung, I.K.H.,Morcrette, H.,Clifton, I.J.,Claridge, T.D.W.,Kawamura, A.,Flashman, E.,Lu, X.,Ratcliffe, P.J.,Chowdhury, R.,Pugh, C.W.,Schofield, C.J. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8:7651-7668, 2017 Cited by PubMed: 29435217 DOI: 10.1039/c7sc02103h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation