5OP8
Factor Inhibiting HIF (FIH) in complex with zinc and Molidustat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hypoxia-inducible factor 1-alpha inhibitor | polymer | 350 | 40415.4 | 1 | UniProt (Q9NWT6) Pfam (PF13621) | Homo sapiens (Human) | Factor inhibiting HIF-1,FIH-1,Hypoxia-inducible factor asparagine hydroxylase |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)-1~{H}-pyrazol-3-one | non-polymer | 314.3 | 1 | Chemie (A1H) | |||
| 4 | D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | G, H (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | I (A) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 1 - 349 (UniProt: Q9NWT6)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40415.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 852.1 | |
| All* | Total formula weight | 41267.4 |
