7TRP
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7LLL
| Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | Descriptor: | Exendin-4, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. | Deposit date: | 2021-02-04 | Release date: | 2022-01-12 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
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7TRQ
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 | Descriptor: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRS
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine | Descriptor: | ACETYLCHOLINE, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7LLY
| Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. | Deposit date: | 2021-02-04 | Release date: | 2022-01-12 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
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8EV1
| Dual Modulators | Descriptor: | (3aR,4S,9bS)-4-(4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide, (3aS,4R,9bR)-4-(4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide, Estrogen Receptor, ... | Authors: | Tinivella, A, Nwachukwu, J.C, Angeli, A, Foschi, F, Benatti, A.L, Pinzi, L, Izard, T, Ferraroni, M, Rangarajan, E.S, Christodoulou, M, Passarella, D, Supuran, C, Nettles, K.W, Rastelli, G. | Deposit date: | 2022-10-19 | Release date: | 2022-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors. Eur.J.Med.Chem., 246, 2022
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5W68
| Type II secretin from Enteropathogenic Escherichia coli - GspD | Descriptor: | Putative type II secretion protein | Authors: | Hay, I.D, Belousoff, M.J, Dunstan, R, Bamert, R, Lithgow, T. | Deposit date: | 2017-06-16 | Release date: | 2017-11-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure and Membrane Topography of the Vibrio-Type Secretin Complex from the Type 2 Secretion System of Enteropathogenic Escherichia coli. J. Bacteriol., 200, 2018
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8PDR
| Rigid body fit of assembled HMPV N-RNA spiral bound to the C-terminal region of P | Descriptor: | Nucleoprotein, Phosphoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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8PDN
| Spiral of assembled human metapneumovirus (HMPV) N-RNA | Descriptor: | Nucleoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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4ZEJ
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6SPF
| Pseudomonas aeruginosa 70s ribosome from an aminoglycoside resistant clinical isolate | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | Deposit date: | 2019-09-01 | Release date: | 2019-10-23 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate. Proc.Natl.Acad.Sci.USA, 116, 2019
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6SPD
| Pseudomonas aeruginosa 50s ribosome from a clinical isolate | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | Authors: | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | Deposit date: | 2019-09-01 | Release date: | 2019-10-16 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate. Proc.Natl.Acad.Sci.USA, 116, 2019
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6SPG
| Pseudomonas aeruginosa 70s ribosome from a clinical isolate | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | Deposit date: | 2019-09-01 | Release date: | 2019-10-16 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate. Proc.Natl.Acad.Sci.USA, 116, 2019
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6SPE
| Pseudomonas aeruginosa 30s ribosome from a clinical isolate | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | Deposit date: | 2019-09-01 | Release date: | 2019-10-16 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate. Proc.Natl.Acad.Sci.USA, 116, 2019
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7KI0
| Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein | Descriptor: | 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | Deposit date: | 2020-10-22 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep, 36, 2021
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7KI1
| Taspoglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs Protein | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | Deposit date: | 2020-10-22 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep, 36, 2021
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1W6B
| Solution NMR Structure of a Long Neurotoxin from the Venom of the Asian Cobra, 20 Structures | Descriptor: | LONG NEUROTOXIN 1 | Authors: | Talebzadeh-Farooji, M, Amininasab, M, Elmi, M.M, Naderi-Manesh, H, Sarbolouki, M.N. | Deposit date: | 2004-08-17 | Release date: | 2004-12-22 | Last modified: | 2018-05-09 | Method: | SOLUTION NMR | Cite: | Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy. Eur. J. Biochem., 271, 2004
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8PDP
| 10-mer ring of HMPV N-RNA bound to the C-terminal region of P | Descriptor: | Nucleoprotein, Phosphoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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8PDQ
| 11-mer ring of HMPV N-RNA bound to the C-terminal region of P | Descriptor: | Nucleoprotein, Phosphoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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8PDM
| 11-mer ring of human metapneumovirus (HMPV) N-RNA | Descriptor: | Nucleoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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8PDO
| Local refinement of dimeric human metapneumovirus (HMPV) N-RNA | Descriptor: | Nucleoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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8PDL
| 10-mer ring of human metapneumovirus (HMPV) N-RNA | Descriptor: | Nucleoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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8PDS
| Local refinement of dimeric HMPV N-RNA bound to the C-terminal region of P | Descriptor: | Nucleoprotein, Phosphoprotein, RNA | Authors: | Whitehead, J.D, Decool, H, Leyrat, C, Carrique, L, Fix, J, Eleouet, J.F, Galloux, M, Renner, M. | Deposit date: | 2023-06-12 | Release date: | 2023-12-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. Nat Commun, 14, 2023
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6YJL
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2QLM
| Glycogen phosphorylase in complex with FN67 | Descriptor: | Glycogen phosphorylase, muscle form, N-{[(4-methylphenyl)carbonyl]carbamoyl}-beta-D-glucopyranosylamine | Authors: | Oikonomakos, N.G, Chryina, E.D, Tiraidis, C, Kosmopoulou, M.N, Zographos, S.E, Leonidas, D.D. | Deposit date: | 2007-07-13 | Release date: | 2008-07-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation To be Published
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